The role of microglia in ASDs.
Project/Area Number |
26460094
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pharmacology in pharmacy
|
Research Institution | The University of Tokyo |
Principal Investigator |
Koyama Ryuta 東京大学, 大学院薬学系研究科(薬学部), 准教授 (90431890)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | マイクログリア / シナプス / 自閉症 / 海馬 / シナプス刈り込み / シナポトーシス / カスパーゼ / 培養切片 / 神経活動 |
Outline of Final Research Achievements |
Selective elimination of inappropriate synapses is fundamental to the refinement of neural circuits. Deficits in synapse elimination are suggested in autism spectrum disorders (ASDs). Here we investigated whether and how the deficits in synapse elimination in the hippocampus are involved in the pathogenesis of ASDs. We found that the deficits in microglia-mediated synapse elimination induce excess synaptic connections in the dentate gyrus-CA3 neural circuits in ASDs. Thus, we propose that the regulation of microglial activity is a key to suppress the development of ASDs.
|
Report
(4 results)
Research Products
(22 results)