| Project/Area Number |
26460123
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山口 文徳 香川大学, 医学部, 准教授 (40271085)
神鳥 和代 香川大学, 医学部, 助教 (40457338)
董 有毅 香川大学, 医学部, 助教 (90457341)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | D-allose / rare sugar / anti-oxidant / MAPK / D-アロース / 抗酸化作用 / 抗炎症作用 / マクロファージ / トランスポーター / 希少糖 |
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| Outline of Final Research Achievements |
D-allose, one of rare sugars, has anti-oxidative action, and is expected to have action to carbohydrate and lipid metabolism. By metabolome analysis, we found a total reducing potential increased significantly in cells and tissues. We also found that D-allose enhanced TXNIP (Thioredoxin Interacting Protein) expression. TXNIP expression and its phosphorylation were regulated by MAPK signaling system. By autoradiographic analysis of D-allose, we found that D-allose goes through blood brain barrier, and that D-allose is safe as a food material. We therefore could established the foundation of application of D-allose.
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