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Application of naturally occurring retinoid X receptor agonists to lifestyle-related diseases and inflammatory diseases

Research Project

Project/Area Number 26460134
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Natural medicines
Research InstitutionAichi Gakuin University

Principal Investigator

INOUE Makoto  愛知学院大学, 薬学部, 教授 (50191888)

Co-Investigator(Renkei-kenkyūsha) NAKASHIMA Ken-ichi  愛知学院大学, 薬学部, 助教 (70635135)
TANABE Hiroki  愛知学院大学, 薬学部, 講師 (10415606)
Research Collaborator TAKAGI Michiyo  
OH I  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsレチノイドX受容体 / 核内受容体 / 天然生理活性物質 / 生活習慣病 / 抗炎症作用 / 天然物 / 天然由来アゴニスト / インスリン抵抗性 / 皮膚炎
Outline of Final Research Achievements

There are only a few reports concerning naturally occurring retinoid X receptor (RXR) agonists, of which biological functions in vivo are expected so much. In this study focusing on naturally occurring RXR agonists, we explored new agonists, investigated their characteristics, and sought to apply them for animal models of several diseases. SPF1 and SPF2 isolated from the roots of Sophora tonkinensis and drupanin isolated from Brazilian propolis were intensively studied. We found that that SPF1 and SPF2 showed anti-inflammatory effect via RXR/LXR heterodimer, induced metallothionein II synergistically in the presence of zinc, and protected nerve-like cells from the death induced by amyloid β. Drupanin also showed anti-inflammatory effect and protective effect on cell death induced by Aβ. We demonstrated for the first time that RXR agonists possess this kind of biological effects.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2016 2015 2014 Other

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Invited: 1 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Yuccalides A-C, three new phenolic compounds with spiro-structures from the roots of Yucca gloriosa.2016

    • Author(s)
      Ken-ichi Nakashima, Naohito Abe, Masayoshi Oyama, Makoto Inoue.
    • Journal Title

      Fitoterapia

      Volume: 111 Pages: 154-159

    • DOI

      10.1016/j.fitote.2016.04.009

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Rexinoids isolated from Sophora tonkinensis with a gene expression profile distinct from the synthetic rexinoid bexarotene.2014

    • Author(s)
      Inoue M, Tanabe H, Nakashima K, Ishida Y, Kotani H.
    • Journal Title

      J Nat Prod.

      Volume: 25;77(7) Issue: 7 Pages: 1670-7

    • DOI

      10.1021/np5002016

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of a naturally occurring retinoid X receptor agonist from Brazilian green propolis2014

    • Author(s)
      Ken-ichi Nakashima, Tohru Murakami, Hiroki Tanabe, Makoto Inoue
    • Journal Title

      Biochimica et Biophysica Acta-General Subjects

      Volume: 1840 Pages: 3034-3041

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] サンズコン由来RXRアゴニストのMetallothionein誘導作用に関する研究2016

    • Author(s)
      王蔚,中島健一,井上誠
    • Organizer
      日本生薬学会第63回年会
    • Place of Presentation
      富山国際会議場(富山県・富山市)
    • Year and Date
      2016-09-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 分子標的型研究:和漢薬成分の核内受容体を介した生体調節作用2016

    • Author(s)
      井上誠
    • Organizer
      第33回和漢医薬学会学術大会
    • Place of Presentation
      星薬科大学(東京都・品川区)
    • Year and Date
      2016-08-27
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] サンズコン由来RXRアゴニストprenylflavanonesの抗炎症作用(2)2016

    • Author(s)
      王蔚,中島健一,井上誠
    • Organizer
      第62回日本薬学会東海支部総会・大会
    • Place of Presentation
      愛知学院大学薬学部(愛知県・名古屋市)
    • Year and Date
      2016-07-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] サンズコン由来RXRアゴニストにより誘導される抗炎症作用関連遺伝子の発現解析2015

    • Author(s)
      王 蔚、中島健一、田邊宏樹、井上 誠
    • Organizer
      日本生薬学会第62回年会
    • Place of Presentation
      長良川国際会議場(岐阜市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Presentation] サンズコン由来RXRアゴニストprenylflavanonesの抗炎症作用2014

    • Author(s)
      王 蔚、中島健一、田邊宏樹、井上誠
    • Organizer
      日本生薬学会第61回年会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-14
    • Related Report
      2014 Research-status Report
  • [Presentation] Drupanin is naturally occurring retinoid X receptor agonist from Brazilian green propolis2014

    • Author(s)
      Ken-ichi Nakashima, Toshiyuki Tanaka, Hiroko Murata, Kouichi Kaburagi, Makoto Inoue
    • Organizer
      The American Society of Pharmacognosy 2014 annual meeting
    • Place of Presentation
      Mississippi, USA
    • Year and Date
      2014-08-04
    • Related Report
      2014 Research-status Report
  • [Remarks] 愛知学院大学薬学部薬用資源学講座

    • URL

      http://www.phar.agu.ac.jp/lab/med_res/top.html

    • Related Report
      2015 Research-status Report
  • [Remarks] 薬用資源学講座

    • URL

      http://www.phar.agu.ac.jp/lab/med_res/top.html

    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] レチノイドX受容体アゴニスト剤2014

    • Inventor(s)
      井上誠,中島健一,田邊宏樹,池野久美子,中村正
    • Industrial Property Rights Holder
      井上誠,中島健一,田邊宏樹,池野久美子,中村正
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-10-10
    • Acquisition Date
      2016-04-15
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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