Development of Specific Determination Methods for Perfluorinated-alkyl Compounds Based on Fluorous LC
| Project/Area Number |
26460182
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HAYAMA Tadashi 福岡大学, 薬学部, 准教授 (90549693)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | フルオラス化学 / 環境分析 / パーフルオロアルキル化合物 / 誘導体化分析 / 前処理 / 分離分析 / 蛍光分析 / MS分析 / フルオラス抽出 / PFOA / PFOS / パーフルオロ化合物 |
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| Outline of Final Research Achievements |
Liquid chromatography (LC) with pre-column fluorescence/MS derivatization methods have been developed to determine the perfluorinated-alkyl compounds (PFCs), such as perfluorooctanoic acid (PFOA) and fluorotelomer alcohols (FTOHs). These methods are based on the derivatization with some pyrene and DMEQ reagents, the LC separation on PFC-modified reversed-phase column, and the sensitive detection by fluorimetry and/or the selective detection by MS/MS. Examined LC column can retain specifically PFCs by means of fluorophilic or “fluorous” interaction. Therefore, by using this technique, effective separation of the derivatized-PFCs from excess reagents and some matrix components could be achieved, and highly specific analysis was enabled by the fluorescence or MS detection. The proposed methods based on fluorous interaction will enable sufficiently sensitive and selective analysis of PFCs in many different types of real samples.
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Report
(5 results)
Research Products
(44 results)
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[Journal Article] Assessment of the Efficacy of Anticancer Drugs by Amino Acid Metabolomics Using Fluorescence Derivatization-HPLC2014
Author(s)
Ryoko Tomita, Kenichiro Todoroki, Kazuyuki Machida, Sho Nishida, Hiroshi Maruoka, Hideyuki Yoshida, Toshihiro Fujioka, Manabu Nakashima, Masatoshi Yamaguchi, Hitoshi Nohta
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Journal Title
Analytical Sciences
Volume: 30
Issue: 7
Pages: 751-758
DOI
NAID
ISSN
0910-6340, 1348-2246
Related Report
Peer Reviewed / Open Access
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