Research on inciting factor of neurological symptoms following low dose methylmercury exposure in fetal period
| Project/Area Number |
26460187
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | National Institute for Minamata Disease |
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Principal Investigator |
Fujimura Masatake 国立水俣病総合研究センター, 基礎研究部, 室長 (20416564)
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| Co-Investigator(Kenkyū-buntansha) |
臼杵 扶佐子 国立水俣病総合研究センター, その他部局等, 部長 (50185013)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 低濃度メチル水銀 / 胎児期曝露 / 神経症状 / メチル水銀 / 小脳 / 神経突起 / シナプス蛋白 |
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| Outline of Final Research Achievements |
We clarified that a low level methylmercury exposure (5 ppm in drinking water) during fetal period induced neurological symptoms without inducing neuronal cell death through the suppression of eEF1A1 and subsequent nerve hypoplasia in rat cerebellum. Furthermore, we also clarified that a low level methylmercury (10 nM) inhibited the proliferation of neuronal cells through the induction of GSK-3b in neural progenitor cells of rats.
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Report
(4 results)
Research Products
(14 results)
