Role of microRNA on the pharmacokinetics of calcineurin inhibitors after living liver transplantation
Project/Area Number |
26460196
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Medical pharmacy
|
Research Institution | Mie University |
Principal Investigator |
OKUDA Masahiro 三重大学, 医学部附属病院, 教授 (70252426)
|
Co-Investigator(Kenkyū-buntansha) |
岩本 卓也 三重大学, 医学部附属病院, 准教授 (30447867)
池村 健治 三重大学, 医学部附属病院, 助教 (70513935)
村木 優一 三重大学, 医学部附属病院, 副薬剤部長 (50571452)
伊佐地 秀司 三重大学, 医学系研究科, 教授 (70176121)
|
Research Collaborator |
HIRAMATSU Shunichi
HAMADA Yugo
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 臓器移植 / マイクロRNA / 免疫抑制薬 / 炎症性サイトカイン / マイクロRNA / 免役抑制薬 / P-糖タンパク質 / CYP3A / PXR |
Outline of Final Research Achievements |
Our study demonstrates that blood concentrations of tacrolimus (an immunosuppressant) are transiently elevated in patients with poor metabolizer of CYP3A5 in the early postoperative period of renal transplantation, and this is attributable to decreased CYP3A4 level via interleukin-6. On the other hand, microRNAs (miRNAs) affecting individual variations in the pharmacokinetics of immunosuppressant after organ transplantations was not identified in the present study. Further study is needed to achieve personalized pharmacotherapy with miRNAs.
|
Report
(4 results)
Research Products
(26 results)
-
-
[Journal Article] Co-administration of proton pump inhibitors ameliorates nephrotoxicity in patients receiving chemotherapy with cisplatin and fluorouracil: a retrospective cohort study.2017
Author(s)
Ikemura K, Oshima K, Enokiya T, Okamoto A, Oda H, Mizuno T, Ishinaga H, Muraki Y, Iwamoto T, Takeuchi K, Katayama N, Okuda M
-
Journal Title
Cancer Chemotherapy and Pharmacology
Volume: 印刷中
Issue: 5
Pages: 943-949
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
[Journal Article] Incidence and Risk Factors of Postoperative Delirium following Pancreatic Surgery: Does the Administration of TJ-54 Reduce the Incidence of Delirium?2017
Author(s)
Mizuno S, Takeuchi S, Kishiwada M, Mizutani N, Matsuda M, Sekoguchi N, Iizawa Y, Azumi Y, Kuriyama N, Usui M, Sakurai H, Maruyama K, Okuda M, Okada M, Isaji S.
-
Journal Title
Dig Surg
Volume: -
Issue: 1
Pages: 1-10
DOI
Related Report
Peer Reviewed
-
[Journal Article] Japanese antimicrobial consumption surveillance: First report on oral and parenteral antimicrobial consumption in Japan (2009-2013).2016
Author(s)
Muraki Y, Yagi T, Tsuji Y, Nishimura N, Tanabe M, Niwa T, Watanabe T, Fujimoto S, Takayama K, Murakami N, Okuda M.
-
Journal Title
Journal of Global Antimicrobial Resistance
Volume: 7
Pages: 19-23
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
[Journal Article] Long-term influence of CYP3A5 gene polymorphism on pharmacokinetics of tacrolimus and patient outcome after living donor liver transplantation.2016
Author(s)
Kato H, Usui M, Muraki Y, Tanemura A, Murata Y, Kuriyama N, Azumi Y, Kishiwada M, Mizuno S, Sakurai H, Okuda M, Nakatani K, Isaji S.
-
Journal Title
Transplantation Proceedings
Volume: 48
Issue: 4
Pages: 1087-1094
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
[Presentation] Lansoprazole exacerbates pemetrexed-mediated hematological toxicity by competitive inhibition of renal basolateral human organic anion transporter 32016
Author(s)
Ikemura K, Hamada Y, Kaya C, Enokiya T, Muraki Y, Nakahara H, Fujimoto H, Kobayashi T, Iwamoto T, Okuda M
Organizer
2016 AAPS ANNUAL MEETING AND EXPOSITION
Place of Presentation
Colorado Convention Center (Colorado, USA)
Year and Date
2016-11-13
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-