Development of the personalized medicine for pulmonary arterial hypertension by the pharmacogenomic approach
Project/Area Number |
26460213
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Medical pharmacy
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Research Institution | Kobe Pharmaceutical University |
Principal Investigator |
Emoto Noriaki 神戸薬科大学, 薬学部, 教授 (30294218)
|
Co-Investigator(Kenkyū-buntansha) |
辻 剛 社会医療法人神鋼記念会(総合医学研究センター), 総合医学研究センター, 助手(移行) (00437493)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 肺高血圧症 / 個別化医療 / ゲノム / エンドセリン受容体拮抗薬 / 遺伝子多型 / ボセンタン / 遺伝子多型・変異 |
Outline of Final Research Achievements |
The purpose of this study was to create the clinical database for pulmonary hypertension and to identify genomic biomarkers that predict effectiveness and adverse effects of disease targeting drugs. An exploratory analysis of 1,936 SNPs in 231 genes involved in absorption, distribution, metabolism, and elimination of multiple medications using DMET chips, was performed. We extracted 16 SNPs using Jonckheere-Terpstra trend test, and by using multiplex logistic analysis, we identified two SNPs in two genes significantly associated with bosentan-induced liver injury. We conducted ROC analysis by using 2 SNPs and 2 items of non-genetic factor, and we constructed predictive model for bosentan-induced liver injury. These results may provide not only a way to personalized medicine for PAH but also novel mechanistic insights on drug-induced liver dysfunction.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Association of Apical Longitudinal Rotation with Right Ventricular Performance in Patients with Pulmonary Hypertension: Insights into Overestimation of Tricuspid Annular Plane Systolic Excursion.2015
Author(s)
Motoji Y, Tanaka H, Fukuda Y, Sano H, Ryo K, Sawa T, Miyoshi T, Imanishi J, Mochizuki Y, Tatsumi K, Matsumoto K, Emoto N, Hirata K.
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Journal Title
Echocardiography.
Volume: 33
Issue: 2
Pages: 207-215
DOI
Related Report
Peer Reviewed
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[Journal Article] Use of Coils and a Pulmonary Vasodilator to Reduce Pulmonary Hypertension in a Patient with Interstitial Pneumonia and Scleroderma2015
Author(s)
Teguh Ryanto GR, Nakayama K, Takaya T, Fujimoto D, Kinutani H, Shinkura Y, Mori S, Okada T, Nishii T, Kono A, Shinke T, Emoto N, Hirata K.
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Journal Title
Internal Medicine
Volume: 54
Issue: 21
Pages: 2721-2726
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed / Open Access
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[Journal Article] Knockout of endothelial cell-derived endothelin-1 attenuates skin fibrosis but accelerates cutaneous wound healing.2014
Author(s)
Makino K, Jinnin M, Aoi J, Kajihara I, Makino T, Fukushima S, Sakai K, Nakayama K, Emoto N, Yanagisawa M, Ihn H.
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Journal Title
PLoS One.
Volume: 22
Issue: 5
Pages: e97972-e97972
DOI
Related Report
Peer Reviewed
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[Journal Article] Utility of combining assessment of right ventricular function and right atrial remodeling as a prognostic factor for patients with pulmonary hypertension.2014
Author(s)
Fukuda Y, Tanaka H, Motoji Y, Ryo K, Sawa T, Imanishi J, Miyoshi T, Mochizuki Y, Tatsumi K, Matsumoto K, Shinke T, Emoto N, Hirata K.
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Journal Title
Int J Cardiovasc Imaging.
Volume: 30
Issue: 7
Pages: 1269-1277
DOI
Related Report
Peer Reviewed
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