| Project/Area Number |
26460226
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
Iwao Yasunori 静岡県立大学, 薬学部, 准教授 (30433022)
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| Co-Investigator(Kenkyū-buntansha) |
野口 修治 東邦大学, 薬学部, 教授 (60237823)
板井 茂 静岡県立大学, 薬学部, 教授 (80453059)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 減感作 / 製剤学 / マイクロ・ナノデバイス / アレルギー・ぜんそく / スギ花粉 / 減感作療法 |
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| Outline of Final Research Achievements |
In this study, to develop a sustained-release formulation for cedar pollen-specific desensitization therapy, we determined the necessary amount or released rate of cryptomeria japonica pollen 1 (CryJ1), one of main allergen antigens of Japan cedar pollen, and we tried to prepare sustained-release formulation with long-term stability of CryJ1. As a result, the CryJ1 released rate to lead to immune tolerances was found to be 132 ng/day, and we succeeded in preparing PLAPEG9604H microspheres containing CryJ1 showing the sustained release at zero order manner. In addition, any structural changes of the cryj1 after long-term incubation were not found to influence the desensitization therapy.
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