| Project/Area Number |
26460229
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Hokkaido Pharmaceutical University School of Pharmacy |
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Principal Investigator |
Toda Takaki 北海道薬科大学, 薬学部, 教授 (00254706)
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| Co-Investigator(Kenkyū-buntansha) |
猪爪 信夫 北海道薬科大学, 薬学部, 教授 (10191892)
早川 達 北海道薬科大学, 薬学部, 教授 (50337044)
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| Research Collaborator |
YAMASHITA Miki
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | エポキシエイコサトリエン酸類 / アンジオテンシンII受容体拮抗薬 / エイコサノイド類 / 相互作用 / アラキドン酸 / P450(CYP) / 血清中濃度 / エポキシエイコサトリエン類 / LC-MS/MS / EETs |
|---|
| Outline of Final Research Achievements |
We investigated the influence of angiotensin II receptor blockers (ARBs) on the serum concentrations of eicosanoids (epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids, which are arachidonic acid metabolites) in patients. Multivariate analysis showed that eGFR (estimated GFR) was negatively associated with the serum levels of eicosanoids, and ARBs significantly decreased the levels. In addition, the serum levels of eicosanoids were significantly decreased in hypertensive patients regardless of whether they were taking ARBs.
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