Relationship between serum EETs concentrations and cardiovascular events in patients taking angiotensin II receptor blockers
Project/Area Number |
26460229
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Medical pharmacy
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Research Institution | Hokkaido Pharmaceutical University School of Pharmacy |
Principal Investigator |
Toda Takaki 北海道薬科大学, 薬学部, 教授 (00254706)
|
Co-Investigator(Kenkyū-buntansha) |
猪爪 信夫 北海道薬科大学, 薬学部, 教授 (10191892)
早川 達 北海道薬科大学, 薬学部, 教授 (50337044)
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Research Collaborator |
YAMASHITA Miki
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | エポキシエイコサトリエン酸類 / アンジオテンシンII受容体拮抗薬 / エイコサノイド類 / 相互作用 / アラキドン酸 / P450(CYP) / 血清中濃度 / エポキシエイコサトリエン類 / LC-MS/MS / EETs |
Outline of Final Research Achievements |
We investigated the influence of angiotensin II receptor blockers (ARBs) on the serum concentrations of eicosanoids (epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids, which are arachidonic acid metabolites) in patients. Multivariate analysis showed that eGFR (estimated GFR) was negatively associated with the serum levels of eicosanoids, and ARBs significantly decreased the levels. In addition, the serum levels of eicosanoids were significantly decreased in hypertensive patients regardless of whether they were taking ARBs.
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Report
(4 results)
Research Products
(6 results)
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[Presentation] Effect of angiotensin II receptor blockers on serum levels of epoxyeicosatrienoic acids2017
Author(s)
Yuka Kato, Asuna Senda, Yuji Mukai, Miki Yamashita, Yuki Sasaoka, Minayo Hanada, Fuminori Hongo, Mitsugu Hirokami, Anders Rane, Nobuo Inotsume, Takaki Toda
Organizer
15th Congress of IATDMCT
Place of Presentation
京都
Year and Date
2017-09-24
Related Report
Int'l Joint Research
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[Presentation] Serum concentrations of eicosatrienoic acids in patients treated with and without angiotensin II receptor blockers2015
Author(s)
Senda A, Mukai Y, Yamashita M, Toda T, Sasaoka Y, Hanada M, Hongo F, Hirokami M, Sato S, Eliasson E, Anders R, Inotsume N
Organizer
The 14th congress of IATDMCT 2015
Place of Presentation
ロッテルダム
Year and Date
2015-10-11
Related Report
Int'l Joint Research
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