| Project/Area Number |
26460235
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Hoshi University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KOBAYASHI Tsuneo 星薬科大学, 薬学部, 教授 (90339523)
ONISHI Hiraku 星薬科大学, 薬学部, 教授 (00160565)
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| Research Collaborator |
TAGUCHI Kumiko
ISHIHARA Chizuko
NIGA Monami
KATAYAMA Sota
INOUE Mizuki
KANGAWA Yoko
MURAI Marina
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ポリフェノール / 過酸化脂質 / モリン / 固体脂質微粒子 / 生物学的利用率 / エマルション / ナノエマルション |
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| Outline of Final Research Achievements |
As a result of intraperitoneal administration of polyphenols to diabetic mice, a strong inhibitory effects on lipid peroxidation was observed in morin. Morin may be useful for relief from complaints related to lipid peroxidation, but because of its extremely low bioavailability, we developed solid lipid nanoparticles (SLN) for the purpose of improving bioavailability. SLN was prepared using hard fat as a base with ethylcellulose and low saponification-degree polyvinyl alcohol. As a result of oral administration of the SLN to mice, drug absorption was improved as compared with administration of morin bulk powder. Furthermore, we developed nanoemulsions containing morin. As a result of oral administration of the prepared nanoemulsion to mice, drug absorption was increased as compared with the administration of morin bulk powder.
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