Fucosylation regulates reproduction system development.
| Project/Area Number |
26460269
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Chiba University |
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Principal Investigator |
BABA Atsushi 千葉大学, 大学院医学研究院, 助教 (70405215)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 器官形成 / 糖鎖修飾 / フコシル化 / 発生・分化 / 細胞・組織 / 管腔様構造 / 糖鎖 / 平面内細胞極性 / 脳神経 |
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| Outline of Final Research Achievements |
Developmental defect in the formation of tubular-like structure, is the relatively common desease in human, but its cause remains unknown. Celsr1 inactivation leads to anatomic block of tublar-like structure in reproductive system, and those phenotypes are mimicked in mice with inactivation of Lunatic fringe, which encodes an O-fucose-Nacetylglucosaminyltransferase. Two EGF-like motifs in Celsr1 are O-fucosylated and subject to Fringe modification. Mutation of O-fucosylation sites hampers decreases cell surface expression of the full length protein. Thus, post-transcriptional glycosylation regulates subcellular localization of Celsr1 protein, and participates in the formation of tubular-like structure.
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Report
(4 results)
Research Products
(4 results)
