| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
Developmental defect in the formation of tubular-like structure, is the relatively common desease in human, but its cause remains unknown. Celsr1 inactivation leads to anatomic block of tublar-like structure in reproductive system, and those phenotypes are mimicked in mice with inactivation of Lunatic fringe, which encodes an O-fucose-Nacetylglucosaminyltransferase. Two EGF-like motifs in Celsr1 are O-fucosylated and subject to Fringe modification. Mutation of O-fucosylation sites hampers decreases cell surface expression of the full length protein. Thus, post-transcriptional glycosylation regulates subcellular localization of Celsr1 protein, and participates in the formation of tubular-like structure.
|
