Amplification of intracellular signaling initiated near the plasma membrane transporters
Project/Area Number |
26460312
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General physiology
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Research Institution | Osaka Medical College (2016) National Cardiovascular Center Research Institute (2014-2015) |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
Jin Meihua 国立循環器病研究センター, 肺高血圧症先端医学研究部, 研究員 (40746773)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 心筋リモデリング / 細胞内シグナル伝達 / Ca2+結合蛋白質 / 心肥大 / 低酸素刺激 / ノックアウトマウス / イオン輸送体 / シグナル伝達 / 遺伝子改変マウス / 心不全 / カテコールアミン / Na+/H+交換輸送体 / ベータリセプター |
Outline of Final Research Achievements |
Many problems have emerged at the beginning of study, and we changed the direction of study related to NHE1. We proceeded the study successfully for the most part. (1) A beta-blocker were found to have a potential for improvement of the disease in a Tg mouse of NHE1 which causes a heart failure. (2) In vitro study using cultured cells revealed that NHE1-binding protein CHP3 negatively regulates cardiomyocyte hypertrophy via inhibition of GSK3beta. (3) Analysis of CHP3 knockout mice revealed that CHP3 negatively regulates cardiac hypertrophy caused by a chronic hypoxia by regulating the expression level of CHP3.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Tescalcin is a potential target of class I histone deacetylase inhibitors in neurons.2017
Author(s)
Takamatsu G, Katagiri C, Tomoyuki T, Shimizu-Okabe C, Nakamura W, Nakamura-Higa M, Hayakawa T, Wakabayashi S, Kondo T, Takayama C, Matsushita M.
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Journal Title
Biochem Biophys Res Commun.
Volume: 482
Issue: 4
Pages: 1327-1333
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Lack of TRPV2 impaired thermogenesis in mouse brown adipose tissue.2016
Author(s)
1.Sun, W., Uchida, K., Suzuki, Y., Zhou, Y., Kim, M., Takayama, Y., Takahashi, N., Goto, T., Wakabayashi, S., Kawada, T., Iwata, Y., and Tominaga, M
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Journal Title
EMBO Report
Volume: 17
Issue: 3
Pages: 383-399
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Osmosensation in TRPV2 dominant negative expressing skeletal muscle fibres.2015
Author(s)
3.Zanou, N., Mondin, L., Fuster, C., Seghers, F., Dufour, I., Clippele, M., Schakman, O., Tajeddine, N., Iwata, Y., Wakabayashi, S., Voets, T., Allard, B., and Gailly, P
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Journal Title
J. Physiol.
Volume: 593(17)
Issue: 17
Pages: 3849-3863
DOI
Related Report
Peer Reviewed
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[Journal Article] Deficiency of a lipid droplet protein, Perilipin 5, suppresses myocardial lipid accumulation, thereby preventing diabetes-induced heart malfunction2014
Author(s)
Kenta Kuramoto, Fumie Sakai, Nana Yoshinori, Tomoe Y. Nakamura, Shigeo Wakabayashi, Tomoko Kojidani, Tokuko Haraguchi, Fumiko Hirose,Takashi Osumi
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Journal Title
Molecular and Cellular Biology
Volume: 34(14)
Issue: 14
Pages: 2721-2731
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Absence of TRPV2 impaired BAT thermogenesis in mice.2015
Author(s)
Sun, W., Uchida, K., Suzuki, Y., Zhou, Y., Kim, M., Takayama, Y., Takahashi, N., Goto, T., Wakabayashi, S., Kawada, T., Y., and Tominaga, M
Organizer
The 5th International Ion Channel Conference
Place of Presentation
Luzhou, Sichuan, China
Year and Date
2015-06-26
Related Report
Int'l Joint Research
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[Presentation] Aerobic treadmill training prevents the obesity caused by gene disruption of Ca2+-sensor protein in mice2015
Author(s)
Wakabayashi, S., Nakao, S., Inagaki, T., Tsuchimochi, H., Nakamura, T.Y., Shirai, M.
Organizer
第92回日本生理学会
Place of Presentation
神戸国際展示場
Year and Date
2015-03-23
Related Report
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[Presentation] Role of Ca2+ sensor-1 in learning and memory in mice2015
Author(s)
Nakao, S., Nakajo, Y., Takahashi, J.C., Nakagawa, O., Wakabayashi, S., Yamamoto, H., and Nakamura-Nishitani, T.Y.
Organizer
第92回日本生理学会
Place of Presentation
神戸国際展示場
Year and Date
2015-03-21
Related Report
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