Exploration of gating against delivery of photic information to the mammalian central circadian clock
| Project/Area Number |
26460326
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Kindai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鯉沼 聡 近畿大学, 医学部, 講師 (10340770)
池上 啓介 近畿大学, 医学部, 助教 (10709330)
筋野 貢 近畿大学, 医学部, 助教 (30460843)
升本 宏平 近畿大学, 医学部, 助教 (60580529)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 視交叉上核 / 体内時計 / 概日リズム / 日内リズム / 日周リズム / 網膜 / Gating / Dead zone / メラノプシン / GABA / 網膜神経節細胞 |
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| Outline of Final Research Achievements |
In the retina, using cFOS as a marker for neural excitation, we found dead zone in which cFos induction does not occur even by light exposure. Furthermore, there is a phase dependency in the cFos induction even in ganglion cells expressing melanopsin that were projected to the suprachiasmatic nucleus. This suggests that the optical information delivered to the suprachiasmatic nucleus is regulated at the retinal level. We also clarified the shift pattern of the phase of the gating in the SCN. The manner of the phase shift of the gate is well corresponded with the phase shift of the circadian rhythm in the dorsal part of the suprachiasmatic nucleus (DMSCN). This finding suggests that the circadian clock in the DMSCN determines the phase of the gate.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Establishment of an in vitro cell line experimental system for the studablishment of an in vitro cell line experimental system for the study oy of inhalational anesthetic mechanisms.2016
Author(s)
Nagamoto S, Iijima N, Ishii H, Takumi K, Higo S, Aikawa S, Anzai M, Matsuo I, Nakagawa S, Takashima N, Shigeyoshi Y, Sakamoto A, Ozawa H.
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Journal Title
Neurosci Lett.
Volume: 4;620:
Pages: 163-168
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Tissue-specific post-translational modification allows functional targeting of thyrotropin2014
Author(s)
Ikegami K, Liao XH, Hoshino Y, Ono H, Ota W, Ito Y, Nishiwaki-Ohkawa T, Sato C, Kitajima K, Iigo M, Shigeyoshi Y, Yamada M, Murata Y, Refetoff S, Yoshimura T
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Journal Title
Cell Reports
Volume: 9
Issue: 3
Pages: 801-809
DOI
Related Report
Peer Reviewed / Open Access
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