Involvement of spinal gap junction in induction and maintenance of chronic pain
| Project/Area Number |
26460342
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中島 一恵 (久岡一恵 / 中島 一恵(久岡一恵)) 広島大学, 医歯薬保健学研究院(薬), 助教 (20393431)
仲田 義啓 広島大学, 医歯薬保健学研究院(薬), 名誉教授 (40133152)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 神経障害性疼痛 / アストロサイト / connexin43 / 脊髄アストロサイト / interleukin-6 / cyclooxygenase-2 / GSK-3β / TNF / グルタミン酸トランスポーター / ユビキチン / プロテアソーム / グルタミン酸 / connexin36 |
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| Outline of Final Research Achievements |
Spinal dorsal horn astrocytic Cx43 decreased following a peripheral nerve injury. Reduction of Cx43 induced neuropathic pain through downregulation of GLT-1, upregulation of interleukin-6 and cyclooxygenase-2 in spinal dorsal horn. Restoring Cx43 by an adenovirus vector expressing Cx43 or treatment with lycopene ameliorated neuropathic pain. Tumor necrosis factor (TNF) contributed to downregulation of Cx43 expression following peripheral nerve injury. In addition, the ubiquitin-proteasome system was involved in TNF-induced downregulation of Cx43 in cultured spinal astrocytes.
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Report
(4 results)
Research Products
(17 results)
