| Project/Area Number |
26460350
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Tenri Health Care University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
的場 聖明 京都府立医科大学, 医学(系)研究科(研究院), 教授 (10305576)
金井 雅史 京都大学, 医学研究科, 特定准教授 (70432416)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 心不全 / 抗がん剤 / ミトコンドリア / オートファジー / エネルギー代謝 / 心筋障害 / がん / 薬物療法 / 心筋保護 |
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| Outline of Final Research Achievements |
Using GFP-LC3 transgenic mice or neonatal rat cardiac myocytes, we demonstrated that Curcumine inhibited both cardiac apoptosis and cardiac dysfunction induced-by Doxorubicin. Curcumine significantly improved mortality in mice with anti-cancer chemotherapy (Clin Exp Card.2015). Also, we showed that cardiac autophagy was activated and acted as cardioprotection by through mTOR-independent Akt signal in the heart failure with sympathicotonia (Biochem Biophys Res Commun.2014). In addition, defect in metabolism of lipid and amino acid was revealed to be a key for the progress of heart failure (Am J Physiol Heart Circ Physio.2016, Sci Rep 2017). These findings indicated that regulating energy metabolism and autophagy would be a novel therapeutic target for heart failure with cancer chemotherapy.
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