Research for heart protection during cancer chemotherapy via regulating cardiac autophagy
Project/Area Number |
26460350
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General pharmacology
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Research Institution | Tenri Health Care University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
的場 聖明 京都府立医科大学, 医学(系)研究科(研究院), 教授 (10305576)
金井 雅史 京都大学, 医学研究科, 特定准教授 (70432416)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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Keywords | 心不全 / 抗がん剤 / ミトコンドリア / オートファジー / エネルギー代謝 / 心筋障害 / がん / 薬物療法 / 心筋保護 |
Outline of Final Research Achievements |
Using GFP-LC3 transgenic mice or neonatal rat cardiac myocytes, we demonstrated that Curcumine inhibited both cardiac apoptosis and cardiac dysfunction induced-by Doxorubicin. Curcumine significantly improved mortality in mice with anti-cancer chemotherapy (Clin Exp Card.2015). Also, we showed that cardiac autophagy was activated and acted as cardioprotection by through mTOR-independent Akt signal in the heart failure with sympathicotonia (Biochem Biophys Res Commun.2014). In addition, defect in metabolism of lipid and amino acid was revealed to be a key for the progress of heart failure (Am J Physiol Heart Circ Physio.2016, Sci Rep 2017). These findings indicated that regulating energy metabolism and autophagy would be a novel therapeutic target for heart failure with cancer chemotherapy.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] D-Glutamate is metabolized in the heart mitochondria.2016
Author(s)
M. Ariyoshi, M. Katane, K. Hamase, Y. Miyoshi, M. Nakane, A. Hoshino, Y. Okawa, Y. Mita, S. Kaimoto, M. Uchihashi, K. Fukai, K. Ono, S. Tateishi, D. Hato, R. Yamanaka, S. Honda, Y. Fushimura, E. Iwai-Kanai, N. Ishihara, M. Mita, H. Homma, and S. Matoba.
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Journal Title
Sci. Rep.
Volume: 7
Issue: 1
Pages: 43911-43911
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Curcumin attenuates doxorubicin-induced cardiotoxicity by inducing autophagy via the regulation of JNK phosphorylation2014
Author(s)
M Katamura, E Iwai-Kanai, M Nakaoka, Y Okawa, M Ariyoshi, Y Mita, A Nakamura, K Ikeda, T Ogata, T Ueyama, S Matoba
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Journal Title
J Clin Exp Cardiolog
Volume: 5
Issue: 09
Pages: 337-337
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Age Related Cardiac Dysfunction and Pancreatic β-cell Function in Diabetes Were Improved by P53 Inhibition Through Parkin-mediated Mitophagy.2016
Author(s)
Ariyoshi M, Katane M, Hamase K, Miyoshi Y, Nakane M, Hoshino A, Okawa Y, Mita Y, Kaimoto S, Uchihashi M, Fukai K, Ono K, Tateishi S, Hato D, Yamanaka R, Honda S, Fushimura Y, Iwai-Kanai E, Ishihara N, Mita M, Homma H, Matoba S.
Organizer
AHA Scientific Sessions 2017
Place of Presentation
New Orleans, LA, USA
Year and Date
2016-11-12
Related Report
Int'l Joint Research
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[Presentation] Efficacy and Safety of Therapeutic Angiogenesis by Basic Fibroblast Growth Factor With Atelocollagen Solution in Patients with Critical Limb Ischemia.2016
Author(s)
Ohno K, Kojima S, Ariyoshi M, Kaimoto S, Uchihashi M, Kaneda H, Kagimura T, Fukushima M, Iwai-Kanai E, Matoba S.
Organizer
AHA Scientific Sessions 2017
Place of Presentation
New Orleans, LA, USA
Year and Date
2016-11-12
Related Report
Int'l Joint Research
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[Presentation] Ketone Body Metabolizing Enzyme 3-hydroxybutyrate Dehydrogenase 1 (Bdh1)2015
Author(s)
Shuhei Tateishi, Motoki Uchihashi, Atsushi Hoshino, Makoto Ariyoshi, Kazunori Ono, Satoshi Kaimoto, Kuniyoshi Fukai, Eri Iwai-Kanai, Satoaki Matoba
Organizer
American Heart Association Scientific Sessions 2015
Place of Presentation
Orlando, FL, USA
Year and Date
2015-11-07
Related Report
Int'l Joint Research
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[Presentation] Bdh1 Reduced Oxidative Stress and Cardiac Remodeling in Pressure Overload Heart Failure2015
Author(s)
Uchihashi M, Atsushi Hoshino, Makoto Ariyoshi, Shuhei Tateishi, Kazunori Ono, Satoshi Kaimoto, Kuniyoshi Fukai, Eri Kanai, Satoaki Matoba, iwai-kanai, E, Matoba S.
Organizer
The 79th Annual Scientific Meeting of Japanese Circulation Society
Place of Presentation
Osaka, Japan
Year and Date
2015-04-24 – 2015-04-26
Related Report
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[Presentation] Activation of PPARα During the Progressive Phase of Heart Failure Improved Myocardial Energetics and Function in Pressure Overload Heart Failure2014
Author(s)
Satoshi Kaimoto, Atsushi Hoshino, Makoto Ariyoshi, Yoshifumi Okawa, Motoki Uchihashi, Kuniyoshi Fukai, Kazunori Ono, Shuhei Tateishi, Eri Iwai-Kanai, and Satoaki Matoba
Organizer
American Heart Association Scientific Sessions2014
Place of Presentation
Chicago, Illinois 60007, United States
Year and Date
2014-11-15 – 2014-11-19
Related Report