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"Brain-type" glycosylation: A tag for diagnostic markers of central nervous system diseases

Research Project

Project/Area Number 26460394
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathological medical chemistry
Research InstitutionFukushima Medical University

Principal Investigator

Hashimoto Yasuhiro  福島県立医科大学, 医学部, 教授 (80164797)

Co-Investigator(Kenkyū-buntansha) 苅谷 慶喜  福島県立医科大学, 医学部, 准教授 (00458217)
伊藤 浩美  福島県立医科大学, 医学部, 講師 (00450669)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords脳炎 / 脳症 / けいれん性疾患 / α2マクログロブリン / 髄液 / 全身性エリテマトーデス / 中枢神経障害 / 急性散在性脳脊髄炎 / α2マクログロブリン / 急性散財性脳脊髄炎 / 脳炎/脳症 / 熱性けいれん / 診断マーカー
Outline of Final Research Achievements

Alpha2-macroglobulin (α2M) is a glycoprotein in the blood and increases at early stages of inflammation. α2MG is a potent endogenous inhibitor for proteases and prevents harmful expansion of inflammation. In the present study, we quantified levels of α2MG in cerebrospinal fluid (CSF) of central nervous system diseases; i.e., acute disseminated encephalomyelitis (ADEM) and neuropsychiatric systemic lupus erythematous (NPSLE). The levels of α2MG in CSF of NPSLE were significantly higher than those of non-NPSLE, indicating that α2MG is a diagnostic marker for NPSLE. At early stage of ADEM, the levels of α2MG in CSF were significantly higher than those of benign febrile seizure (FS), suggesting that α2MG is a marker at early stage of ADEM. Thus, we concluded that α2MG could be a marker for inflammation in central nervous system.

Academic Significance and Societal Importance of the Research Achievements

小児の発熱は頻度の高い症状である。この中には単なる熱発や熱性けいれんとともに、命にかかわる脳炎や脳症などが含まれることがある。例えば、脳症であれば発病の1日目に適切な治療を行えば80%が救命されるが、2日目の診断では40%、3日目の診断では10%にまで救命率が低下する。従って、脳症の病初期における診断は極めて重要であるが、従来は良い診断マーカーが知られていなかった。本研究で、脳内で生合成されるα2Mが脳炎・脳症のマーカーになることが示された。今後、イムノクロマト法でのベッドサイド診断による迅速診断が期待される。

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (46 results)

All 2018 2017 2016 2015 2014 Other

All Journal Article (17 results) (of which Peer Reviewed: 13 results,  Open Access: 5 results,  Acknowledgement Compliant: 4 results) Presentation (27 results) (of which Int'l Joint Research: 2 results,  Invited: 6 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Spontaneous intracranial hypotension is diagnosed by a combination of lipocalin-type prostaglandin D synthase and brain-type transferrin in cerebrospinal fluid2018

    • Author(s)
      Yuta Murakami, Koichi Takahashi, Kyoka Hoshi, Hiromi Ito, Mayumi Kanno, Kiyoshi Saito, Kenneth Nollet, Yoshiki Yamaguchi, Masakazu Miyajima, Hajime Arai, Yasuhiro Hashimoto, and Tatsuo Mima
    • Journal Title

      BBA General Subjects

      Volume: -

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid increase of “brain-type” transferrin in cerebrospinal fluid after shunt surgery for idiopathic normal pressure hydrocephalus: a prognosis marker for cognitive recovery2018

    • Author(s)
      Yuta Murakami, Yuka Matsumoto, Kyoka Hoshi, Hiromi Ito, Takashi J. Fuwa, Yoshiki Yamaguchi, Madoka Nakajima, Masakazu Miyajima, Hajime Arai, Kenneth Nollet, Naho Kato, Rie Nishikata, Naohito Kuroda, Takashi Honda, Jun Sakuma, Kiyoshi Saito and Yasuhiro Hashimoto
    • Journal Title

      Journal of Biochemistry

      Volume: -

    • NAID

      40021678439

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of blood-brain barrier function by quotient alpha2 macroglobulin and its relationship with interleukin-6 and complement component 3 levels in neuropsychiatric systemic lupus erythematosus2017

    • Author(s)
      Asano Tomoyuki、Ito Hiromi、Kariya Yoshinobu、Hoshi Kyoka、Yoshihara Akioh、Ugawa Yoshikazu、Sekine Hideharu、Hirohata Shunsei、Yamaguchi Yoshiki、Sato Shuzo、Kobayashi Hiroko、Migita Kiyoshi、Ohira Hiromasa、Hashimoto Yasuhiro、Watanabe Hiroshi
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 10 Pages: e0186414-e0186414

    • DOI

      10.1371/journal.pone.0186414

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A unique glycan-isoform of transferrin in cerebrospinal fluid: A potential diagnostic marker for neurological diseases2017

    • Author(s)
      Hoshi Kyoka、Matsumoto Yuka、Ito Hiromi、Saito Kiyoshi、Honda Takashi、Yamaguchi Yoshiki、Hashimoto Yasuhiro
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - General Subjects

      Volume: 1861 Issue: 10 Pages: 2473-2478

    • DOI

      10.1016/j.bbagen.2017.07.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Excess APP O-glycosylation by GalNAc-T6 decreases Aβ production.2017

    • Author(s)
      Keiko Akasaka-Manya, Masaki Kawamura, Hiroki Tsumoto, Yuko Saitoh, Yuriko Tachida, Shinobu Kitazume, Hiroyuki Hatsuta, Yuri Miura, Shin-ichi Hisanaga, Shigeo Murayama, Yasuhiro Hashimoto, Hiroshi Manya, Tamao Endo
    • Journal Title

      J. Biochem.

      Volume: 161 Issue: 1 Pages: 99-111

    • DOI

      10.1093/jb/mvw056

    • NAID

      40021091544

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Lection inhibits antigen-antibody reaction in a glycoform-specific manner: Application for detecting α2,6sialylated-carcinoembryonic antigen2016

    • Author(s)
      Hiromi Ito, Kyoka Hoshi, Fumihiko Osuka, Mitsukazu Gotoh, Takuro Saito, Hiroshi Hojo, Rei Suzuki, Hiromasa Ohira, Takashi Honda and Yasuhiro Hashimoto
    • Journal Title

      PROTEOMICS

      Volume: 16 Pages: 3081-4

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Subgroup differences in “brain-type” transferrin and alpha-synuclein in Parkinson's disease and multiple system atrophy2016

    • Author(s)
      A Yoshihara, M Fukatsu, K Hoshi, Y Hashimoto, et. al
    • Journal Title

      The Journal of Biochemistry

      Volume: 159 Issue: 2 Pages: 87-91

    • DOI

      10.1093/jb/mvw015

    • Description
      未定
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 糖鎖バイオマーカーによる特発性正常圧水頭症と神経変性疾患の鑑別2016

    • Author(s)
      星 京香、吉原章王、深津真彦、金子知香子、伊藤浩美、橋本康弘
    • Journal Title

      生体の科学

      Volume: 67 Pages: 498-499

    • Related Report
      2016 Research-status Report
  • [Journal Article] アルツハイマー病の発症メカニズム:髄液糖鎖マーカーの探索2016

    • Author(s)
      橋本康弘、星 京香
    • Journal Title

      日本臨床検査医学会東北支部会誌

      Volume: 25 Pages: 7-13

    • Related Report
      2016 Research-status Report 2015 Research-status Report
  • [Journal Article] 認知症における糖鎖バイオマーカー2016

    • Author(s)
      星 京香、吉原章王、伊藤浩美、宮嶋雅一、新井 一、宇川義一、古川勝敏、荒井啓行、橋本康弘
    • Journal Title

      老年期認知症研究会誌

      Volume: 21 Pages: 17-19

    • Related Report
      2016 Research-status Report
  • [Journal Article] Subgroup differences in “brain-type” transferrin and alpha-synuclein in Parkinson’s disease and multiple system atrophy2016

    • Author(s)
      Akioh Yoshihara, Masahiko Fukatsu, Kyoka Hoshi, Hiromi Ito, Kenneth Nollet, Yoshiki Yamaguchi, Ryotaro Ishii, Takahiko Tokuda, Masakazu Miyajima, Hajime Arai, Takeo Kato, Katsutoshi Furukawa, Hiroyuki Arai, Akio Kikuchi, Atsushi Takeda, Yoshikazu Ugawa and Yasuhiro Hashimoto
    • Journal Title

      J. Biochem.

      Volume: in press

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 認知症における糖鎖バイオマーカー2016

    • Author(s)
      2.星 京香、吉原章王、伊藤浩美、宮嶋雅一、新井 一、宇川義一、古川勝敏、荒井啓行、橋本康弘
    • Journal Title

      老年期認知症研究会誌

      Volume: in press

    • Related Report
      2015 Research-status Report
  • [Journal Article] Increased cerebrospinal fluid osteopontin levels and its involvement in macrophage infiltration in neuromyelitis optica2015

    • Author(s)
      Yoshinobu Kariya, Yukiko Kariya, Toshie Saito, Shuhei Nishiyama, Takashi Honda, Keiko Tanaka, Mari Yoshida, Kazuo Fujihara and Yasuhiro Hashimoto
    • Journal Title

      BBA Clinical

      Volume: 3 Pages: 126-134

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer’s disease2015

    • Author(s)
      Yasuhiko Kizuka, Shinobu Kitazume, Reiko Fujinawa, Takashi Saito, Nobuhisa Iwata, Takaomi C. Saido, Miyako Nakano, Yoshiki Yamaguchi, Yasuhiro Hashimoto
    • Journal Title

      EMBO Mol. Med.

      Volume: 7(2) Issue: 2 Pages: 175-89

    • DOI

      10.15252/emmm.201404438

    • NAID

      120006799362

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] In situ visualization of a glycoform of transferrin: Localization of α2,6-sialylated transferrin in the liver2015

    • Author(s)
      Yuka Matsumoto, Toshie Saito, Kyoka Hoshi, Hiromi Ito, Yoshinobu Kariya, Masamichi Nagae, Yoshiki Yamaguchi, Yoshiaki Hagiwara, Noriaki Kinoshita, Ikuo Wada, Kiyoshi Saito, Takashi Honda and Yasuhiro Hashimoto
    • Journal Title

      J. Biochem.

      Volume: 157(4) Issue: 4 Pages: 211-216

    • DOI

      10.1093/jb/mvu071

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Osteopontin O-glycosylation contributes to its phosphorylation and cell-adhesion properties2014

    • Author(s)
      Yoshinobu Kariya, Mayumi Kanno, Kana Matsumoto-Morita, Midori Konno, Yoshiki Yamaguchi and Yasuhiro Hashimoto
    • Journal Title

      Biochem. J.

      Volume: 463(1) Issue: 1 Pages: 93-102

    • DOI

      10.1042/bj20140060

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Structural change of N-glycan exposes hydrophobic surface of human transferrin2014

    • Author(s)
      Masamichi Nagae, Kana Morita-Matsumoto, Seisuke Arai, Ikuo Wada, Yuka Matsumoto, Kiyoshi Saito, Yasuhiro Hashimoto and Yoshiki Yamaguchi
    • Journal Title

      Glycobiology

      Volume: 24(8) Issue: 8 Pages: 693-702

    • DOI

      10.1093/glycob/cwu033

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 髄液バイオマーカーによる特発性低髄液圧症候群の診断2017

    • Author(s)
      村上友太、高橋浩一、星 京香、伊藤浩美、菅野真由美、齋藤 清、橋本康弘、美馬達夫
    • Organizer
      第18回日本正常圧水頭症学会
    • Place of Presentation
      北九州市
    • Year and Date
      2017-02-04
    • Related Report
      2016 Research-status Report
  • [Presentation] 脳脊髄液減少症(特発性低髄液圧症候群)と髄液型トランスフェリン2017

    • Author(s)
      橋本康弘、村上友太、齋藤 清、星 京香、菅野真由美、宮嶋雅一、新井 一、高橋浩一、美馬達夫
    • Organizer
      第45回日本頭痛学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 脳脊髄液減少症のバイオマーカーについて2017

    • Author(s)
      橋本康弘
    • Organizer
      AMED障害者対策総合研究開発事業「脳脊髄液減少症における自律神経機能異常の関与の検討」シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] A CSF biomarker for diagnosing spontaneous intracranial hypotension2017

    • Author(s)
      Yuta Murakami, Koichi Takahashi, Kyoka Hoshi, Hiromi Ito, Mayumi Kanno, Kiyoshi Saito, Kenneth Nollet, Yoshiki Yamaguchi, Tatsuo Mima and Yasuhiro Hashimoto
    • Organizer
      The 9th Meeting of the Internaional Society for Hydrocephalus and Cerebrospinal Fluid Disorders (Hydrocephalus 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 糖鎖プローブとしてのレクチン:認知症の糖鎖マーカーの検出2016

    • Author(s)
      橋本康弘
    • Organizer
      第2回レクチン技術研究会
    • Place of Presentation
      東京
    • Year and Date
      2016-12-05
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 特発性低髄液圧症候群の診断における新たな髄液バイオマーカーの模索2016

    • Author(s)
      村上友太、高橋浩一、星 京香、伊藤浩美、菅野真由美、齋藤 清、橋本康弘、美馬達夫
    • Organizer
      第9回日本水頭症脳脊髄液学会
    • Place of Presentation
      名古屋市
    • Year and Date
      2016-11-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 特発性低髄液圧症候群の診断における髄液中バイオマーカー2016

    • Author(s)
      村上友太、星 京香、菅野真由美、伊藤浩美、齋藤 清、橋本康弘、宮嶋雅一、新井 一、高橋浩一、美馬達夫
    • Organizer
      日本脳神経外科学会 第75回学術総会
    • Place of Presentation
      福岡市
    • Year and Date
      2016-09-29
    • Related Report
      2016 Research-status Report
  • [Presentation] ホルマリン固定大腸癌由来のα2,6シアリル化癌胎児性抗原の検出2016

    • Author(s)
      伊藤浩美、星 京香、大須賀文彦、後藤満一、齋藤拓朗、北條 洋、鈴木 玲、大平弘正、本多たかし、橋本康弘
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台市
    • Year and Date
      2016-09-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 髄液中トランスフェリン糖鎖アイソフォームと疾患2016

    • Author(s)
      星 京香、伊藤浩美、安部英理子、不破尚志、菅野真由美、飯島順子、村上友太、齋藤 清、高橋浩一、美馬達夫、橋本康弘
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台市
    • Year and Date
      2016-09-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 部位特異的O-結合型糖鎖修飾がオステオポンチンの細胞接着活性に与える影響2016

    • Author(s)
      今野 翠、苅谷慶喜、苅谷由貴子、菅野真由美、橋本康弘
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台市
    • Year and Date
      2016-09-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 髄液中トランスフェリン糖鎖アイソフォームと疾患2016

    • Author(s)
      星 京香、村上友太、伊藤浩美、安部英理子、不破尚志、菅野真由美、飯島順子、齋藤 清、高橋浩一、美馬達夫、橋本康弘
    • Organizer
      第10回東北糖鎖研究会
    • Place of Presentation
      福島市
    • Year and Date
      2016-08-06
    • Related Report
      2016 Research-status Report
  • [Presentation] ホルマリン固定大腸癌由来のα2,6シアリル化癌胎児性抗原の検出2016

    • Author(s)
      伊藤浩美、星 京香、大須賀文彦、後藤満一、齋藤拓朗、北條 洋、鈴木 玲、大平弘正、本多たかし、橋本康弘
    • Organizer
      第10回東北糖鎖研究会
    • Place of Presentation
      福島市
    • Year and Date
      2016-08-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 特発性低髄液圧症候群の診断における糖鎖バイオマーカーの有用性の検討2016

    • Author(s)
      村上友太、齋藤 清、星 京香、菅野真由美、橋本康弘、宮嶋雅一、新井 一、高橋浩一、美馬達夫
    • Organizer
      第17回日本正常圧水頭症学会
    • Place of Presentation
      山形
    • Year and Date
      2016-03-19
    • Related Report
      2015 Research-status Report
  • [Presentation] 特発性低髄液圧症候群の診断における糖鎖バイオマーカーの探索2015

    • Author(s)
      村上友太、齋藤 清、星 京香、菅野真由美、橋本康弘、宮嶋雅一、新井 一、高橋浩一、美馬達夫
    • Organizer
      第8回日本水頭症脳脊髄液学会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-22
    • Related Report
      2015 Research-status Report
  • [Presentation] 認知症におけるバイオマーカー2015

    • Author(s)
      橋本康弘
    • Organizer
      第21回東北老年期認知症研究会
    • Place of Presentation
      仙台
    • Year and Date
      2015-11-21
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Subgroup differences in “brain-type” transferrin and alpha-synuclein in Parkinson’s disease and multiple system atrophy2015

    • Author(s)
      Akioh Yoshihara, Masahiko Fukatsu, Kyoka Hoshi, Hiromi Ito, Ryotaro Ishii, Takahiko Tokuda, Masakazu Miyajima, Hajime Arai, Takeo Kato, Katsutoshi Furukawa, Hiroyuki Arai, Akio Kikuchi, Atsushi Takeda, Yoshiki Yamaguchi, Yoshikazu Ugawa and Yasuhiro Hashimoto
    • Organizer
      7th Asian Community of Glycoscience and Glycotechnology Conference (ACGG)
    • Place of Presentation
      Matsushima, Miyagi
    • Year and Date
      2015-11-12
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 髄液α2マクログロブリンは神経炎症マーカーになりうる2015

    • Author(s)
      鈴木雄一、宮崎恭平、佐藤晶諭、橋本浩一、星京香、橋本康弘、細谷光亮
    • Organizer
      第47回日本小児感染症学会総会・学術集会
    • Place of Presentation
      福島
    • Year and Date
      2015-10-31
    • Related Report
      2015 Research-status Report
  • [Presentation] 髄液中トランスフェリン測定の意義2015

    • Author(s)
      星 京香,吉原章王, 深津真彦,伊藤浩美,石井亮太郎,徳田隆彦,宮嶋雅一,新井 一,加藤丈夫,古川勝敏,荒井啓行,菊池昭夫,武田 篤,山口芳樹,宇川義一,橋本康弘
    • Organizer
      第9回東北糖鎖研究会発表会・第9回東北薬科大学分子生体膜研究所(IMBG)シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2015-09-04
    • Related Report
      2015 Research-status Report
  • [Presentation] 認知症の糖鎖バイオマーカー2015

    • Author(s)
      橋本康弘
    • Organizer
      S.T.R. Medical Conference
    • Place of Presentation
      郡山、福島
    • Year and Date
      2015-08-05
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] アルツハイマー病の発症メカニズム:髄液糖鎖マーカーの探索2015

    • Author(s)
      橋本康弘
    • Organizer
      第47回日本臨床検査医学会東北支部総会
    • Place of Presentation
      福島
    • Year and Date
      2015-07-25
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 糖鎖欠損によるオステオポンチンの細胞接着活性とリン酸化修飾への影響2015

    • Author(s)
      今野翠、苅谷慶喜、菅野真由美、苅谷由貴子、橋本康弘
    • Organizer
      第47回日本結合組織学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-15
    • Related Report
      2015 Research-status Report
  • [Presentation] 特発性正常圧水頭症における糖鎖バイオマーカーとその臨床症状との関係2015

    • Author(s)
      村上友太、松本由香、星 京香、伊藤浩美、齋藤 清、本多たかし、中島 円、宮嶋雅一、新井 一、橋本康弘
    • Organizer
      第16回日本正常圧水頭症学会
    • Place of Presentation
      岡山
    • Year and Date
      2015-02-28
    • Related Report
      2014 Research-status Report
  • [Presentation] igh throughput detection of an alpha2,6-sialylated glycoform of transferrin in cerebrospinal fluid: Application for dementia diagnosis2014

    • Author(s)
      Kyoka Hoshi, Toshie Saito, Hiromi Ito, Yoshinobu Kariya, Takashi Honda, Yoshiki Yamaguchi, Yasuhiro Hashimoto
    • Organizer
      SFG-JSCR
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2014-11-16 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 特発性正常圧水頭症の糖鎖バイオマーカー2014

    • Author(s)
      橋本康弘、星 京香、伊藤浩美、苅谷慶喜、村上友太、齋藤 清、本多たかし、中島 円、宮嶋雅一、新井 一
    • Organizer
      第7回日本水頭症脳脊髄液学会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-26
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] α2,6シアル酸化トランスフェリンの迅速測定及び免疫組織化学2014

    • Author(s)
      星 京香、斎藤利江、松本由香、村上友太、伊藤浩美、苅谷慶喜、齋藤 清、本多たかし、橋本康弘
    • Organizer
      第8回東北糖鎖研究会
    • Place of Presentation
      岩手
    • Year and Date
      2014-10-10
    • Related Report
      2014 Research-status Report
  • [Presentation] Bisecting GlcNAc欠損によるアルツハイマー病抑制に関する研究2014

    • Author(s)
      木塚康彦、北爪しのぶ、藤縄玲子、斎藤貴志、岩田修永、西道隆臣、中の三弥子、山口芳樹、橋本康弘、Matthias Staufenbiel、初田裕幸、村山繁雄、萬谷 博、遠藤玉夫、谷口直之
    • Organizer
      第33回日本糖質学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-08-12
    • Related Report
      2014 Research-status Report
  • [Presentation] レクチンによる抗原-抗体反応の阻害:髄液トランスフェリン糖鎖アイソフォームの測定2014

    • Author(s)
      星 京香、松本由香、伊藤浩美、苅谷慶喜、松本加奈、長江雅倫、山口芳樹、中島 円、宮嶋雅一、新井 一、久野 敦、成松 久、齋藤 清、本多たかし、橋本康弘
    • Organizer
      第33回日本糖質学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-08-10
    • Related Report
      2014 Research-status Report
  • [Book] Annual Review神経20152015

    • Author(s)
      星 京香、橋本康弘、本多たかし、新井 一、宮嶋雅一、荒井啓行、古川勝敏
    • Total Pages
      7
    • Publisher
      (株)中外医学社
    • Related Report
      2015 Research-status Report
  • [Remarks] 生化学講座ホームページ

    • URL

      http://hashimoto-lab.org/

    • Related Report
      2016 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2021-12-27  

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