Cancer stem cell targeting by fatty acid signals
Project/Area Number |
26460424
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Nara Medical University |
Principal Investigator |
Ohmori Hitoshi 奈良県立医科大学, 医学部, 研究員 (80213875)
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Co-Investigator(Kenkyū-buntansha) |
國安 弘基 奈良県立医科大学, 医学部, 教授 (00253055)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | エライジン酸 / リノール酸 / がん幹細胞 / マイクロRNA / トランス脂肪酸 / Gタンパク共役受容体 / EGFR / Wnt / 脂肪酸 / シグナル / 転移 |
Outline of Final Research Achievements |
Effect of fatty acids is studied on mechanism of cancer stem activation, influence to cancer metastasis and chemoresistance. Elaidic acid, a trans fatty acid, showed high potential promoting cancer metastasis by activating cancer stem cells by 1) transactivation of EGFR and the subsequent wnt activation, and 2) inhibition of expression of pro-differentiation genes by micro RNAs. Linoleic acid, an ω-6 long chain fatty acid, induced gene expression of dormant-stem-associated factors and enhanced survival of cancer stem cells against chemotherapy.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Pro-metastatic intracellular signaling of elaidic acid, a trans fatty acid.2017
Author(s)
Fujii K, Luo Y, Nishiguchi Y, Fujiwara R, Kishi S, He S, Yang S, Sasaki T, Ohmori H, Kuniyasu H
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Journal Title
Int J Oncol
Volume: 50
Issue: 1
Pages: 85-92
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Elaidic acid, a trans fatty acid, enhances the metastasis of colorectal cancer cells2017
Author(s)
Ohmori H, Fujii K, Kadochi Y, Mori S, Nishiguchi Y, Fujiwara R, Kishi S, Sasaki T, Kuniyasu H
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Journal Title
Pathobiol
Volume: in press
Issue: 3
Pages: 144-151
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Expression of MAS1 in breast cancer.2015
Author(s)
Luo Y, Tanabe E, Kitayoshi M, Nishiguchi Y, Fujiwara R, Matsushima S, Sasaki T, Sasahira T, Chihara Y, Fujii K, Ohmori H, Kuniyasu H
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Journal Title
Cancer Sci
Volume: 106
Issue: 9
Pages: 1240-1248
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Pro-chemotherapeutic effects of antibody against extracellular domain of claudin-4 in bladder cancer2015
Author(s)
Masaomi Kuwada, Yoshitomo Chihara, Yi Luo, Xiangru Li, Yukiko Nishiguchi, Rina Fujiwara, Takamistu Sasaki, Kiyomu Fujii, Hitoshi Ohmori, Kiyohide Fujimoto, Masuo Kondoh, Hiroki Kuniyasu
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Journal Title
Cancer Letters
Volume: 369
Issue: 1
Pages: 212-221
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Serum CD10 is associated with liver metastasis in colorectal cancer.2014
Author(s)
Sasaki T, Kuniyasu H, Luo Y, Fujiwara R, Kitayoshi M, Tanabe E, Kato D, Shinya S, Fujii K, Ohmori H, Yamashita Y
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Journal Title
Journal of Surgical Research
Volume: 192
Issue: 2
Pages: 390-394
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Protumoral role of trans fatty acid2016
Author(s)
Ohmori H, Kuwai T, Kitadai Y, Fujii K, Fujiwara R, Nishiguchi Y, Sasahira T, Kuniyasu H
Organizer
Annual Meeting of American Association for Cancer Research 2016
Place of Presentation
New Orleans, USA
Year and Date
2016-04-16
Related Report
Int'l Joint Research
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[Presentation] 糖尿病合併大腸癌の特徴2015
Author(s)
國安弘基、藤原里奈、佐々木隆光、大森 斉
Organizer
第104回日本病理学会総会
Place of Presentation
名古屋
Year and Date
2015-04-30
Related Report
Invited
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[Book] Current Research in Cancer 92015
Author(s)
Kuniyasu H*, Ohmori H, Fujii K, Iwata N, Katsuragawa H, Fujiwara R, Sasaki T
Total Pages
216
Publisher
Research Media, Kerala, India,
Related Report
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