Cancer stem cell targeting by fatty acid signals

• Project/Area Number: 26460424
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Nara Medical University
• Principal Investigator: Ohmori Hitoshi 奈良県立医科大学, 医学部, 研究員 (80213875)
• Co-Investigator(Kenkyū-buntansha): 國安 弘基 奈良県立医科大学, 医学部, 教授 (00253055)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: エライジン酸 / リノール酸 / がん幹細胞 / マイクロRNA / トランス脂肪酸 / Gタンパク共役受容体 / EGFR / Wnt / 脂肪酸 / シグナル / 転移

Outline of Final Research Achievements

Effect of fatty acids is studied on mechanism of cancer stem activation, influence to cancer metastasis and chemoresistance. Elaidic acid, a trans fatty acid, showed high potential promoting cancer metastasis by activating cancer stem cells by 1) transactivation of EGFR and the subsequent wnt activation, and 2) inhibition of expression of pro-differentiation genes by micro RNAs. Linoleic acid, an ω-6 long chain fatty acid, induced gene expression of dormant-stem-associated factors and enhanced survival of cancer stem cells against chemotherapy.

Research Products

• [Journal Article] Pro-metastatic intracellular signaling of elaidic acid, a trans fatty acid. (2017)
  • Author(s): Fujii K, Luo Y, Nishiguchi Y, Fujiwara R, Kishi S, He S, Yang S, Sasaki T, Ohmori H, Kuniyasu H
  • Journal Title: Int J Oncol Volume: 50 Issue: 1 Pages: 85-92
  • DOI: 10.3892/ijo.2016.3797
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Elaidic acid, a trans fatty acid, enhances the metastasis of colorectal cancer cells (2017)
  • Author(s): Ohmori H, Fujii K, Kadochi Y, Mori S, Nishiguchi Y, Fujiwara R, Kishi S, Sasaki T, Kuniyasu H
  • Journal Title: Pathobiol Volume: in press Issue: 3 Pages: 144-151
  • DOI: 10.1159/000449205
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Proton pump inhibitor induces-collagen expression in colonocytes is associated with collagenous colitis. (2017)
  • Author(s): Mori S, Kadochi Y, Luo Y, Fujiwara-Tani R, Nishiguchi Y, Kishi S, Fujii K, Ohmori H, Kuniyasu H
  • Journal Title: World J Gastroentrol Volume: 23 Issue: 9 Pages: 1586-1593
  • DOI: 10.3748/wjg.v23.i9.1586
  • Peer Reviewed / Open Access
• [Journal Article] Remodeling of energy metabolism by a ketone body and medium-chain fatty acid suppressed proliferation of CT26 mouse colon cancer cells (2017)
  • Author(s): Kadochi Y, Mori S, Fujiwara-Tani R, Luo Y, Nishiguchi Y, Kishi S, Fujii K, Ohmori H, Kuniyasu H
  • Journal Title: Oncol Lett Volume: in press
  • Peer Reviewed / Open Access
• [Journal Article] Fatty acids induce stemness in the stromal cells of a CT26 mouse tumor model (2017)
  • Author(s): Kawahara I, Mori T, Goto K, Fujii K, Ohmori H, Fujiwara-Tani R, Kuniyasu H
  • Journal Title: Pathobiol Volume: in press Issue: 5 Pages: 237-242
  • DOI: 10.1159/000471854
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] High motility group box 1 induces cancer aggressiveness and drug resistance. (2015)
  • Author(s): Ohmori H, Luo Y, Fujii K, Sasaki T, Kuniyasu H
  • Journal Title: Ann Clin Pathol Volume: 3 Pages: 1042-1042
  • Peer Reviewed / Open Access
• [Journal Article] Alteration of the plasma free amino acids profiles in cancer patients is associated with dysregulated metabolism in skeletal muscle (2015)
  • Author(s): Luo Y, Yoneda J, Sasaki T, Kawahara I, Goto K, Fujii K, Ohmori H, Kuniyasu H
  • Journal Title: Arch Cancer Res Volume: 3 Pages: 5-5
  • Peer Reviewed / Open Access
• [Journal Article] Expression of MAS1 in breast cancer. (2015)
  • Author(s): Luo Y, Tanabe E, Kitayoshi M, Nishiguchi Y, Fujiwara R, Matsushima S, Sasaki T, Sasahira T, Chihara Y, Fujii K, Ohmori H, Kuniyasu H
  • Journal Title: Cancer Sci Volume: 106 Issue: 9 Pages: 1240-1248
  • DOI: 10.1111/cas.12719
  • Peer Reviewed / Open Access
• [Journal Article] Cancer therapeutic effects of titanium dioxide nanoparticles are associated with oxidative stress and cytokine induction (2015)
  • Author(s): Fujiwara R, Luo Y, Sasaki T, Fujii K, Ohmori H, Kuniyasu H
  • Journal Title: Pathobiol Volume: 82 Issue: 6 Pages: 243-251
  • DOI: 10.1159/000439404
  • Peer Reviewed
• [Journal Article] Pro-chemotherapeutic effects of antibody against extracellular domain of claudin-4 in bladder cancer (2015)
  • Author(s): Masaomi Kuwada, Yoshitomo Chihara, Yi Luo, Xiangru Li, Yukiko Nishiguchi, Rina Fujiwara, Takamistu Sasaki, Kiyomu Fujii, Hitoshi Ohmori, Kiyohide Fujimoto, Masuo Kondoh, Hiroki Kuniyasu
  • Journal Title: Cancer Letters Volume: 369 Issue: 1 Pages: 212-221
  • DOI: 10.1016/j.canlet.2015.08.019
  • Peer Reviewed / Open Access
• [Journal Article] High motility group box 1 induces cancer aggressiveness and drug resistance (2015)
  • Author(s): Ohmori H, Luo Y, Fujii K, Sasaki T, Kuniyasu H
  • Journal Title: Annals of Clinical Pathology Volume: 3(1) Pages: 1042-1042
  • Peer Reviewed / Open Access
• [Journal Article] Alteration of the plasma free amino acids profiles in cancer patients is associated with dysregulated metabolism in skeletal muscle (2015)
  • Author(s): Luo Y, Yoneda J, Sasaki T, Kawahara I, Goto K, Fujii K, Ohmori H, Kuniyasu H
  • Journal Title: Archives of Cancer Research Volume: 3(1) Pages: 5-5
  • Peer Reviewed / Open Access
• [Journal Article] AKT activation and telomerase reverse transcriptase expression are concurrently associated with prognosis of gastric cancer. (2014)
  • Author(s): Sasaki T, Ohmori H, et al
  • Journal Title: Pathobiology Volume: 81 Issue: 1 Pages: 36-41
  • DOI: 10.1159/000351721
  • Peer Reviewed / Open Access
• [Journal Article] Cancer usurps skeletal muscle as an energy repository (2014)
  • Author(s): Luo Y, Ohmori H, et al
  • Journal Title: Cancer Res Volume: 74 Issue: 1 Pages: 330-340
  • DOI: 10.1158/0008-5472.can-13-1052
  • Peer Reviewed / Open Access
• [Journal Article] Role of two types of angiotensin II receptors in colorectal carcinoma progression. (2014)
  • Author(s): Zhou L, Luo Y, Sato S, Tanabe E, Kitayoshi M, Fujiwara R, Sasaki T, Fujii K, Ohmori H, Kuniyasu H
  • Journal Title: Pathobiology Volume: 81(4) Issue: 4 Pages: 169-175
  • DOI: 10.1159/000362092
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Serum CD10 is associated with liver metastasis in colorectal cancer. (2014)
  • Author(s): Sasaki T, Kuniyasu H, Luo Y, Fujiwara R, Kitayoshi M, Tanabe E, Kato D, Shinya S, Fujii K, Ohmori H, Yamashita Y
  • Journal Title: Journal of Surgical Research Volume: 192 Issue: 2 Pages: 390-394
  • DOI: 10.1016/j.jss.2014.05.071
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Trans fatty acid enhances the progression of colorectal cancer by activating cancer stem cells. (2016)
  • Author(s): Luo Y, Ohmori H, Kadochi Y, Mori S, Fujii K, Sasaki T, Kuniyasu H
  • Organizer: 76th Annual Meeting of Japanese Association for Cancer
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-06
• [Presentation] Protumoral role of trans fatty acid (2016)
  • Author(s): Ohmori H, Kuwai T, Kitadai Y, Fujii K, Fujiwara R, Nishiguchi Y, Sasahira T, Kuniyasu H
  • Organizer: Annual Meeting of American Association for Cancer Research 2016
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2016-04-16
  • Int'l Joint Research
• [Presentation] High malignant potential in diabetes-complicated colorectal cancer (2015)
  • Author(s): Kuniyasu H, Fujiwara R, Kishi S, Mori S, Kadochi Y, Fujii K, Sasaki T, Ohmori H.
  • Organizer: 75th Annual Meeting of Japanese Association for Cancer
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] Effects of antibody targeting of the extracellular domain of claudin-4 in bladder cancer. (2015)
  • Author(s): Luo Y, Kuwada M, Chihara Y, Sasaki T, Ohmori H, Fujimoto K, Kondoh M, Kuniyasu H.
  • Organizer: 75th Annual Meeting of Japanese Association for Cancer
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] Triple negative乳癌におけるMAS1の発現 (2015)
  • Author(s): 羅 奕、藤原里奈、佐々木隆光、大森 斉、國安弘基
  • Organizer: 第34回日本分子腫瘍マーカー研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-07
• [Presentation] 糖尿病合併大腸癌の特徴 (2015)
  • Author(s): 國安弘基、藤原里奈、佐々木隆光、大森 斉
  • Organizer: 第104回日本病理学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-04-30
  • Invited
• [Presentation] Expression of MAS1 in triple-negative breast cancer. (2015)
  • Author(s): Luo Y, Kitadai Y, Nishiguchi Y, Fujiwara R, Sasaki T, Ohmori H, Kuniyasu H
  • Organizer: Annual Meeting of American Association for Cancer Research 2015
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2015-04-18 – 2015-04-23
• [Presentation] Expression of MAS1 in triple-negative breast cancer. (2015)
  • Author(s): Luo Y, Kitadai Y, Nishiguchi Y, Fujiwara R, Sasaki T, Ohmori H, Kuniyasu H
  • Organizer: Annual Meeting of American Association for Cancer Research 2015
  • Place of Presentation: Philadelphia
  • Year and Date: 2015-04-18
  • Int'l Joint Research
• [Presentation] Claudin-4を標的とする治療の可能性 (2014)
  • Author(s): 國安弘基、羅 奕、千原良友、桑田真臣、北吉美沙穂、田邊絵里子、佐々木隆光、大森 斉、近藤昌夫
  • Organizer: 第29回発癌病理研究会
  • Place of Presentation: いわき市
  • Year and Date: 2014-09-01 – 2014-09-03
• [Presentation] 間欠的カロリー制限の癌幹細胞への影響 (2014)
  • Author(s): 大森 斉、羅 奕、田邊絵里子、北吉美沙穂、藤原里奈、佐々木隆光、國安弘基
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: 広島市
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] Cancer usurps skeletal muscle as an energy repository (2014)
  • Author(s): Luo Y, Yoneda Y, Ohmori H, Sasaki T, Kuniyasu H
  • Organizer: 104th Annual Meeting of American Association for Cancer Research
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-04-05 – 2014-04-09
• [Book] Role of CD10 in the metastasis of colorectal cancer to the liver. (2016)
  • Author(s): Kuniyasu H, Fujii K, Ohmori H, Fujiwara-Tani R, Luo Y, Sasaki T
  • Total Pages: 189
  • Publisher: Research Media
• [Book] Significance of anti-CLDN4 extracellular domain antibody in cancer treatment. (2016)
  • Author(s): Fujiwara-Tani R, Ohmori H, Fujii K, Sasaki T, Luo Y, Kuniyasu H
  • Total Pages: 189
  • Publisher: Research Media
• [Book] Current Research in Cancer 9 (2015)
  • Author(s): Kuniyasu H*, Ohmori H, Fujii K, Iwata N, Katsuragawa H, Fujiwara R, Sasaki T
  • Total Pages: 216
  • Publisher: Research Media, Kerala, India,
• [Book] Encyclopedia of Cancer (2015)
  • Author(s): Kuniyasu H
  • Publisher: Springer-Verlag Berlin Heidelberg
• [Book] Current Research in Cancer 9 (2015)
  • Author(s): Kuniyasu H, Sasaki T, Fujii K, Ohmori H
  • Total Pages: 165
  • Publisher: Research Media, Kerala, India
• [Book] Current Research in Cancer 8 (2014)
  • Author(s): Kuniyasu H, Luo Y, Yoneda J, Sasaki T, Fujii K, Ohmori H
  • Total Pages: 156
  • Publisher: Research Media, Kerala, India
• [Remarks] 奈良県立医科大学分子病理学講座
  • URL: http://www.naramed-u.ac.jp/~molepath/