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Cancer stem cell targeting by fatty acid signals

Research Project

Project/Area Number 26460424
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionNara Medical University

Principal Investigator

Ohmori Hitoshi  奈良県立医科大学, 医学部, 研究員 (80213875)

Co-Investigator(Kenkyū-buntansha) 國安 弘基  奈良県立医科大学, 医学部, 教授 (00253055)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsエライジン酸 / リノール酸 / がん幹細胞 / マイクロRNA / トランス脂肪酸 / Gタンパク共役受容体 / EGFR / Wnt / 脂肪酸 / シグナル / 転移
Outline of Final Research Achievements

Effect of fatty acids is studied on mechanism of cancer stem activation, influence to cancer metastasis and chemoresistance. Elaidic acid, a trans fatty acid, showed high potential promoting cancer metastasis by activating cancer stem cells by 1) transactivation of EGFR and the subsequent wnt activation, and 2) inhibition of expression of pro-differentiation genes by micro RNAs. Linoleic acid, an ω-6 long chain fatty acid, induced gene expression of dormant-stem-associated factors and enhanced survival of cancer stem cells against chemotherapy.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (34 results)

All 2017 2016 2015 2014 Other

All Journal Article (16 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 16 results,  Open Access: 15 results,  Acknowledgement Compliant: 5 results) Presentation (11 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (6 results) Remarks (1 results)

  • [Journal Article] Pro-metastatic intracellular signaling of elaidic acid, a trans fatty acid.2017

    • Author(s)
      Fujii K, Luo Y, Nishiguchi Y, Fujiwara R, Kishi S, He S, Yang S, Sasaki T, Ohmori H, Kuniyasu H
    • Journal Title

      Int J Oncol

      Volume: 50 Issue: 1 Pages: 85-92

    • DOI

      10.3892/ijo.2016.3797

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Elaidic acid, a trans fatty acid, enhances the metastasis of colorectal cancer cells2017

    • Author(s)
      Ohmori H, Fujii K, Kadochi Y, Mori S, Nishiguchi Y, Fujiwara R, Kishi S, Sasaki T, Kuniyasu H
    • Journal Title

      Pathobiol

      Volume: in press Issue: 3 Pages: 144-151

    • DOI

      10.1159/000449205

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Proton pump inhibitor induces-collagen expression in colonocytes is associated with collagenous colitis.2017

    • Author(s)
      Mori S, Kadochi Y, Luo Y, Fujiwara-Tani R, Nishiguchi Y, Kishi S, Fujii K, Ohmori H, Kuniyasu H
    • Journal Title

      World J Gastroentrol

      Volume: 23 Issue: 9 Pages: 1586-1593

    • DOI

      10.3748/wjg.v23.i9.1586

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Remodeling of energy metabolism by a ketone body and medium-chain fatty acid suppressed proliferation of CT26 mouse colon cancer cells2017

    • Author(s)
      Kadochi Y, Mori S, Fujiwara-Tani R, Luo Y, Nishiguchi Y, Kishi S, Fujii K, Ohmori H, Kuniyasu H
    • Journal Title

      Oncol Lett

      Volume: in press

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fatty acids induce stemness in the stromal cells of a CT26 mouse tumor model2017

    • Author(s)
      Kawahara I, Mori T, Goto K, Fujii K, Ohmori H, Fujiwara-Tani R, Kuniyasu H
    • Journal Title

      Pathobiol

      Volume: in press Issue: 5 Pages: 237-242

    • DOI

      10.1159/000471854

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] High motility group box 1 induces cancer aggressiveness and drug resistance.2015

    • Author(s)
      Ohmori H, Luo Y, Fujii K, Sasaki T, Kuniyasu H
    • Journal Title

      Ann Clin Pathol

      Volume: 3 Pages: 1042-1042

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alteration of the plasma free amino acids profiles in cancer patients is associated with dysregulated metabolism in skeletal muscle2015

    • Author(s)
      Luo Y, Yoneda J, Sasaki T, Kawahara I, Goto K, Fujii K, Ohmori H, Kuniyasu H
    • Journal Title

      Arch Cancer Res

      Volume: 3 Pages: 5-5

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of MAS1 in breast cancer.2015

    • Author(s)
      Luo Y, Tanabe E, Kitayoshi M, Nishiguchi Y, Fujiwara R, Matsushima S, Sasaki T, Sasahira T, Chihara Y, Fujii K, Ohmori H, Kuniyasu H
    • Journal Title

      Cancer Sci

      Volume: 106 Issue: 9 Pages: 1240-1248

    • DOI

      10.1111/cas.12719

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cancer therapeutic effects of titanium dioxide nanoparticles are associated with oxidative stress and cytokine induction2015

    • Author(s)
      Fujiwara R, Luo Y, Sasaki T, Fujii K, Ohmori H, Kuniyasu H
    • Journal Title

      Pathobiol

      Volume: 82 Issue: 6 Pages: 243-251

    • DOI

      10.1159/000439404

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pro-chemotherapeutic effects of antibody against extracellular domain of claudin-4 in bladder cancer2015

    • Author(s)
      Masaomi Kuwada, Yoshitomo Chihara, Yi Luo, Xiangru Li, Yukiko Nishiguchi, Rina Fujiwara, Takamistu Sasaki, Kiyomu Fujii, Hitoshi Ohmori, Kiyohide Fujimoto, Masuo Kondoh, Hiroki Kuniyasu
    • Journal Title

      Cancer Letters

      Volume: 369 Issue: 1 Pages: 212-221

    • DOI

      10.1016/j.canlet.2015.08.019

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] High motility group box 1 induces cancer aggressiveness and drug resistance2015

    • Author(s)
      Ohmori H, Luo Y, Fujii K, Sasaki T, Kuniyasu H
    • Journal Title

      Annals of Clinical Pathology

      Volume: 3(1) Pages: 1042-1042

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alteration of the plasma free amino acids profiles in cancer patients is associated with dysregulated metabolism in skeletal muscle2015

    • Author(s)
      Luo Y, Yoneda J, Sasaki T, Kawahara I, Goto K, Fujii K, Ohmori H, Kuniyasu H
    • Journal Title

      Archives of Cancer Research

      Volume: 3(1) Pages: 5-5

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] AKT activation and telomerase reverse transcriptase expression are concurrently associated with prognosis of gastric cancer.2014

    • Author(s)
      Sasaki T, Ohmori H, et al
    • Journal Title

      Pathobiology

      Volume: 81 Issue: 1 Pages: 36-41

    • DOI

      10.1159/000351721

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cancer usurps skeletal muscle as an energy repository2014

    • Author(s)
      Luo Y, Ohmori H, et al
    • Journal Title

      Cancer Res

      Volume: 74 Issue: 1 Pages: 330-340

    • DOI

      10.1158/0008-5472.can-13-1052

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of two types of angiotensin II receptors in colorectal carcinoma progression.2014

    • Author(s)
      Zhou L, Luo Y, Sato S, Tanabe E, Kitayoshi M, Fujiwara R, Sasaki T, Fujii K, Ohmori H, Kuniyasu H
    • Journal Title

      Pathobiology

      Volume: 81(4) Issue: 4 Pages: 169-175

    • DOI

      10.1159/000362092

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Serum CD10 is associated with liver metastasis in colorectal cancer.2014

    • Author(s)
      Sasaki T, Kuniyasu H, Luo Y, Fujiwara R, Kitayoshi M, Tanabe E, Kato D, Shinya S, Fujii K, Ohmori H, Yamashita Y
    • Journal Title

      Journal of Surgical Research

      Volume: 192 Issue: 2 Pages: 390-394

    • DOI

      10.1016/j.jss.2014.05.071

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Trans fatty acid enhances the progression of colorectal cancer by activating cancer stem cells.2016

    • Author(s)
      Luo Y, Ohmori H, Kadochi Y, Mori S, Fujii K, Sasaki T, Kuniyasu H
    • Organizer
      76th Annual Meeting of Japanese Association for Cancer
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Protumoral role of trans fatty acid2016

    • Author(s)
      Ohmori H, Kuwai T, Kitadai Y, Fujii K, Fujiwara R, Nishiguchi Y, Sasahira T, Kuniyasu H
    • Organizer
      Annual Meeting of American Association for Cancer Research 2016
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-04-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High malignant potential in diabetes-complicated colorectal cancer2015

    • Author(s)
      Kuniyasu H, Fujiwara R, Kishi S, Mori S, Kadochi Y, Fujii K, Sasaki T, Ohmori H.
    • Organizer
      75th Annual Meeting of Japanese Association for Cancer
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] Effects of antibody targeting of the extracellular domain of claudin-4 in bladder cancer.2015

    • Author(s)
      Luo Y, Kuwada M, Chihara Y, Sasaki T, Ohmori H, Fujimoto K, Kondoh M, Kuniyasu H.
    • Organizer
      75th Annual Meeting of Japanese Association for Cancer
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] Triple negative乳癌におけるMAS1の発現2015

    • Author(s)
      羅 奕、藤原里奈、佐々木隆光、大森 斉、國安弘基
    • Organizer
      第34回日本分子腫瘍マーカー研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-07
    • Related Report
      2015 Research-status Report
  • [Presentation] 糖尿病合併大腸癌の特徴2015

    • Author(s)
      國安弘基、藤原里奈、佐々木隆光、大森 斉
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-04-30
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Expression of MAS1 in triple-negative breast cancer.2015

    • Author(s)
      Luo Y, Kitadai Y, Nishiguchi Y, Fujiwara R, Sasaki T, Ohmori H, Kuniyasu H
    • Organizer
      Annual Meeting of American Association for Cancer Research 2015
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2015-04-18 – 2015-04-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Expression of MAS1 in triple-negative breast cancer.2015

    • Author(s)
      Luo Y, Kitadai Y, Nishiguchi Y, Fujiwara R, Sasaki T, Ohmori H, Kuniyasu H
    • Organizer
      Annual Meeting of American Association for Cancer Research 2015
    • Place of Presentation
      Philadelphia
    • Year and Date
      2015-04-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Claudin-4を標的とする治療の可能性2014

    • Author(s)
      國安弘基、羅 奕、千原良友、桑田真臣、北吉美沙穂、田邊絵里子、佐々木隆光、大森 斉、近藤昌夫
    • Organizer
      第29回発癌病理研究会
    • Place of Presentation
      いわき市
    • Year and Date
      2014-09-01 – 2014-09-03
    • Related Report
      2014 Research-status Report
  • [Presentation] 間欠的カロリー制限の癌幹細胞への影響2014

    • Author(s)
      大森 斉、羅 奕、田邊絵里子、北吉美沙穂、藤原里奈、佐々木隆光、國安弘基
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島市
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Cancer usurps skeletal muscle as an energy repository2014

    • Author(s)
      Luo Y, Yoneda Y, Ohmori H, Sasaki T, Kuniyasu H
    • Organizer
      104th Annual Meeting of American Association for Cancer Research
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-04-05 – 2014-04-09
    • Related Report
      2014 Research-status Report
  • [Book] Role of CD10 in the metastasis of colorectal cancer to the liver.2016

    • Author(s)
      Kuniyasu H, Fujii K, Ohmori H, Fujiwara-Tani R, Luo Y, Sasaki T
    • Total Pages
      189
    • Publisher
      Research Media
    • Related Report
      2016 Annual Research Report
  • [Book] Significance of anti-CLDN4 extracellular domain antibody in cancer treatment.2016

    • Author(s)
      Fujiwara-Tani R, Ohmori H, Fujii K, Sasaki T, Luo Y, Kuniyasu H
    • Total Pages
      189
    • Publisher
      Research Media
    • Related Report
      2016 Annual Research Report
  • [Book] Current Research in Cancer 92015

    • Author(s)
      Kuniyasu H*, Ohmori H, Fujii K, Iwata N, Katsuragawa H, Fujiwara R, Sasaki T
    • Total Pages
      216
    • Publisher
      Research Media, Kerala, India,
    • Related Report
      2015 Research-status Report
  • [Book] Encyclopedia of Cancer2015

    • Author(s)
      Kuniyasu H
    • Publisher
      Springer-Verlag Berlin Heidelberg
    • Related Report
      2015 Research-status Report
  • [Book] Current Research in Cancer 92015

    • Author(s)
      Kuniyasu H, Sasaki T, Fujii K, Ohmori H
    • Total Pages
      165
    • Publisher
      Research Media, Kerala, India
    • Related Report
      2014 Research-status Report
  • [Book] Current Research in Cancer 82014

    • Author(s)
      Kuniyasu H, Luo Y, Yoneda J, Sasaki T, Fujii K, Ohmori H
    • Total Pages
      156
    • Publisher
      Research Media, Kerala, India
    • Related Report
      2014 Research-status Report
  • [Remarks] 奈良県立医科大学分子病理学講座

    • URL

      http://www.naramed-u.ac.jp/~molepath/

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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