Study of tumor microenvironment in pancreatic cancer and their precursor lesions.
Project/Area Number |
26460425
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Jichi Medical University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 膵癌 / 前癌病変 / 微小環境 / 膵癌前駆病変 / 膵管内腫瘍 / 癌間質 / 肥満細胞 |
Outline of Final Research Achievements |
We studied tumor microenvironment in pancreatic cancer and their precursor lesions. First, we found that mast cell infiltration was significantly increased in the periductal stroma of one of the precursors of pancreatic cancer (IPMNs). Mast cells may be related to tumor progression during non-invasive stage of them. Second, MUC13 expression was more frequently observed in higher grade of IPMN, and was associated with poor prognosis of the patients. Third, using immunohistochemical method, we indicated that atypical flat lesion (AFL), recently described as a precursor of pancreatic cancer mainly in mice, was a possible precursor in human, too. Fourth, since there has been no consensus on the method and criteria for evaluation of lymph vessel invasions (LVIs), we analyzed on the whole of the largest cut sections of the pancreatic cancer specimens and determined appropriate criteria of LVIs. Furthermore, we found distribution of LVIs has a tendency to exist near the duodenum or bile duct.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion.2016
Author(s)
Ikenoue T, Terakado Y, Nakagawa H, Hikiba Y, Fujii T, Matsubara D, Noguchi R, Zhu C, Yamamoto K, Kudo Y, Asaoka Y, Yamaguchi K, Ijichi H, Tateishi K, Fukushima N, Maeda S, Koike K, Furukawa Y
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Journal Title
Sci Rep
Volume: 印刷中
Issue: 1
Pages: 23899-23899
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.2015
Author(s)
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T.
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Journal Title
Am J Surg Pathol.
Volume: 39(12)
Issue: 12
Pages: 1730-1741
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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