• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Telomere measurement of Barrett's esophagus using Q-FISH method

Research Project

Project/Area Number 26460431
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

AIDA Junko  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 専門副部長 (80425678)

Co-Investigator(Renkei-kenkyūsha) IZUMIYAMA Naotaka  地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 助手 (10158751)
NAKAMURA Ken-ichi  地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 研究員 (60159069)
TAKUBO Kaiyo  地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 研究員 (00154956)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsバレット食道 / バレット腺癌 / テロメア / 染色体不安定性 / Q-FISH / Q-FISH法
Outline of Final Research Achievements

In Western countries, Barrett’s esophagus (BE) is defined as columnar-lined esophagus with intestinal metaplasia (IM), because of its risk of cancer development. But, our previous studies have demonstrated a close relationship between Barrett’s carcinoma (BC) and cardiac-type (CT) mucosa. We have revealed excessive telomere shortening with chromosomal instability in precancerous lesions. In the present study, we estimated telomere lengths (TL) in IM, CT, and BC, and compared their chromosomal instabilities. In EMR samples, we measured TL using our original quantitative-FISH method.
IM and CT had longer telomeres then BC, but there was no significant difference in TL between IM and CT, in spite of cancer location or mucin type. Our findings suggest that chromosomal instability due to telomere shortening is not peculiar to IM, and do not support the contention that IM is a particular risk factor for cancer. Therefore, we consider that BE should be regarded as CLE with/without IM.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (16 results)

All 2017 2016 Other

All Int'l Joint Research (3 results) Presentation (6 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Remarks (7 results)

  • [Int'l Joint Research] Klinikum Bayreuth GmbH(ドイツ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Klinikum Bayreuth GmbH.(ドイツ)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Klinikum Bayreuth GmbH(ドイツ)

    • Related Report
      2015 Research-status Report
  • [Presentation] Barrett's adenocarcinoma arise from intestinal or cardiac-type mucosae? Telomere measurement by using quantitative fluorescence in situ hybridization2017

    • Author(s)
      Junko Aida, Naotaka Shimomura, Ken-ichi Nakamura, Naoshi Ishikawa, Kaiyo Takubo, Toshiyuki Ishiwata
    • Organizer
      第5回日本比較病理研究会
    • Place of Presentation
      東京(東京都健康長寿医療センター)
    • Year and Date
      2017-02-18
    • Related Report
      2016 Research-status Report
  • [Presentation] Telomere measurement of intestinal and cardiac-type mucosae in Barrett's oesophagus using quantitative-fluorescence in situ hybridization2016

    • Author(s)
      Aida J, Takubo K, Ishikawa N, Matsuda Y, Arai T, Ishiwata T, Vieth M
    • Organizer
      XXXI International Congress of the International Academy of Pathology and 28th Congress of the European Society of Pathology
    • Place of Presentation
      Cologne, Germany
    • Year and Date
      2016-09-25
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Diagnosis of Barrett's esophagus and chromosomal instability2016

    • Author(s)
      Junko Aida
    • Organizer
      International Gastrointestinal Seminar
    • Place of Presentation
      東京(東京都健康長寿医療センター)
    • Year and Date
      2016-07-29
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Chromosomal Instability in Barrett's esophagus - Telomere measurement using Q-FISH2016

    • Author(s)
      Aida J, Arai T, Ishiwata T, Takubo K
    • Organizer
      第70回日本食道学会学術大会
    • Place of Presentation
      東京(東京プリンスホテル)
    • Year and Date
      2016-07-04
    • Related Report
      2016 Research-status Report
  • [Presentation] Telomere measurement of intestinal- and cardiac-type mucosae in Barrett’s esophagus2016

    • Author(s)
      相田順子、泉山七生貴、仲村賢一、田久保海誉 他
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2016-05-12
    • Related Report
      2015 Research-status Report
  • [Presentation] Histopathologic features for prognostication of superficial Barrett’s carcinoma: Data from a multicenter study in Japan2016

    • Author(s)
      Aida J, Ishizaki T, Arai T, Takubo K.
    • Organizer
      2016 United States & Canadian Academy of Pathology Annual Meeting
    • Place of Presentation
      Washington State Convention Center, Seattle, Washington, USA,
    • Year and Date
      2016-03-12
    • Related Report
      2015 Research-status Report
  • [Remarks] 東京都健康長寿医療センター老年病理学研究チーム高齢者がん研究グループ

    • URL

      http://www.ttaggg-rtgp.org

    • Related Report
      2016 Research-status Report
  • [Remarks] 地方独立行政法人東京都健康長寿医療センター・東京都健康長寿医療センター研究所

    • URL

      http://www.tmig.or.jp/J_TMIG_J_index.html

    • Related Report
      2016 Research-status Report
  • [Remarks] Research Gate 個人ページ

    • URL

      https://www.researchgate.net/profile/Junko_Aida/

    • Related Report
      2016 Research-status Report
  • [Remarks] 東京都健康長寿医療センター研究所 老年病理学研究チーム高齢者がん研究グループ

    • URL

      http://www.ttaggg-rtgp.org

    • Related Report
      2015 Research-status Report
  • [Remarks] 地方独立行政法人東京都健康長寿医療センター・東京都健康長寿医療センター研究所

    • URL

      http://www.tmghig.jp/J_TMIG/J_index.html

    • Related Report
      2015 Research-status Report
  • [Remarks] 東京都健康長寿医療センター研究所老年病理学研究チーム高齢者がん研究グループホームページ

    • URL

      http://www.ttaggg-rtgp.org/

    • Related Report
      2014 Research-status Report
  • [Remarks] Research Gate 個人ページ(Junko Aida)

    • URL

      https://www.researchgate.net/profile/Junko_Aida/

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi