Development of clinical application method of cancer / stem cell related molecule in head and neck cancer

• Project/Area Number: 26460463
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: National Cancer Center Japan
• Principal Investigator: Mori Taisuke 国立研究開発法人国立がん研究センター, 中央病院, 医員 (00296708)
• Research Collaborator: Yoshimoto Seiichi ; Itami Jun
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 頭頸部癌 / 扁平上皮癌 / 幹細胞関連分子 / 頭頸部腫瘍 / がん幹細胞 / 病理診断 / 頭頸部がん / 幹細胞 / 治療抵抗性

Outline of Final Research Achievements

Head - and - neck squamous cell carcinoma, which overexpresses EpCAM, a stem cell - related molecule, was found to be radioresistant. These can be said to be research results directly linked to clinical practice. The expression of EpCAM was thought to make clinical application possible by using microscopic biopsy specimens usually used for diagnosis of cancer and easy to judge by immunohistological examination.

Research Products

• [Journal Article] H3K27me3 Immunohistochemistry in the Diagnosis of Malignant Peripheral Nerve Sheath Tumors. (2017)
  • Author(s): Asano N, Yoshida A, Ichikawa H, Mori T, Nakamura M, Kawai A, Hiraoka N.
  • Journal Title: Histopathology. Volume: 70 Issue: 3 Pages: 385-393
  • DOI: 10.1111/his.13072
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Impact of microscopic orbital periosteum invasion in orbital preservation surgery. (2017)
  • Author(s): Kobayashi K, Mori T, Matsumoto F, Murakami N, Teshima M, Fukasawa M, Matsumoto Y, Matsumura S, Itami J, Asai M, Yoshimoto S.
  • Journal Title: Jpn J Clin Oncol. Volume: 47 Issue: 4 Pages: 321-327
  • DOI: 10.1093/jjco/hyw207
  • Peer Reviewed
• [Journal Article] Prognostic significance of surgical extranodal extension in head and neck squamous cell carcinoma patients. (2017)
  • Author(s): Matsumoto F, Mori T, Matsumura S, Matsumoto Y, Fukasawa M, Teshima M, Kobayashi K, Yoshimoto S.
  • Journal Title: Jpn J Clin Oncol. Volume: 印刷中 Issue: 8 Pages: 699-704
  • DOI: 10.1093/jjco/hyx055
  • Peer Reviewed
• [Journal Article] Disordered arrangements of basal cells as a prognostic factor for oral epithelial dysplasia: a morphometric study of 96 cases. (2016)
  • Author(s): Okamura T, Izumo T, Yagishita H, Mori T, Sakamoto K, Harada K.
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol. Volume: 122 Pages: 355-361
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Chondrosarcoma of the hyoid bone - Report of a case and a literature review of the suitable treatment strategy. (2016)
  • Author(s): Maki D, Mori T, Teshima M, Kobayashi K, Matsumoto F, Sakai A, Okami K, Yoshimoto S.
  • Journal Title: Auris Nasus Larynx Volume: 16 Issue: 5 Pages: 30366-30372
  • DOI: 10.1016/j.anl.2016.09.004
  • Peer Reviewed
• [Journal Article] Significance of delayed primary excision in localized nonmetastatic adult head and neck rhabdomyosarcoma (2016)
  • Author(s): Kobayashi K, Matsumoto F, Kodaira M, Mori T, Murakami N, Yoshida A, Maki D, Teshima M, Fukasawa M, Itami J, Asai M, Yoshimoto S.
  • Journal Title: Cancer Med. Volume: 5 Issue: 10 Pages: 2708-2714
  • DOI: 10.1002/cam4.855
  • Peer Reviewed / Open Access
• [Journal Article] Patterns of recurrence after selective postoperative radiation therapy for patients with head and neck squamous cell carcinoma (2016)
  • Author(s): Murakami N, Matsumoto F, Yoshimoto S, Ito Y, Mori T, Ueno T, Tuchida K, Kashihara T, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Umezawa R, Takahashi K, Inaba K, Igaki H, Itami J
  • Journal Title: BMC Cancer Volume: 16 Issue: 1 Pages: 192-195
  • DOI: 10.1186/s12885-016-2229-x
  • Peer Reviewed / Open Access
• [Journal Article] SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas (2016)
  • Author(s): Ohtomo-Oda R, Komatsu S, Tsuda H et al.
  • Journal Title: Hum Pathol Volume: 49 Pages: 145-155
  • DOI: 10.1016/j.humpath.2015.08.025
  • Peer Reviewed
• [Journal Article] CIC-rearranged Sarcomas: A Study of 20 Cases and Comparisons With Ewing Sarcomas (2016)
  • Author(s): Yoshida A, Goto K, Kodaira M, Kobayashi E, Kawamoto H, Mori T, Yoshimoto S, Endo O, Kodama N, Kushima R, Hiraoka N, Motoi T, Kawai A.
  • Journal Title: Am J Surg Pathol. Volume: 40 Issue: 3 Pages: 313-23
  • DOI: 10.1097/pas.0000000000000570
  • Peer Reviewed
• [Journal Article] Primary intraocular synovial sarcoma in the post retinal detachment operative state (2015)
  • Author(s): Ito J, Suzuki S, Yoshida A, Mori T
  • Journal Title: BMJ Case Rep Volume: 6 Pages: 1-3
  • DOI: 10.1136/bcr-2015-209919
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Expression of EpCAM and prognosis in early-stage glottic cancer treated by radiotherapy (2014)
  • Author(s): Murakami N, Mori T, Yoshimoto S, Ito Y, Kobayashi K, Ken H, Kitaguchi M, Sekii S, Takahashi K, Yoshio K, Inaba K, Morota M, Sumi M, Itami J.
  • Journal Title: Laryngoscope. Volume: Nov;124(11): Issue: 11 Pages: 431-436
  • DOI: 10.1002/lary.24839
  • Peer Reviewed
• [Journal Article] Adenocarcinoma of the pigmented ciliary epithelium. (2014)
  • Author(s): Sukeda A, Mori T, Suzuki S, Ochiai A.
  • Journal Title: BMJ Case Rep. Volume: July 11 Pages: 1-4
  • DOI: 10.1136/bcr-2014-204534
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Basic study of soft tissue augmentation by adipose-inductive biomaterial (2014)
  • Author(s): Yazawa M, Mori T, Nakayama Y, Kishi K
  • Journal Title: J Biomed Mater Res B Volume: (in press) Issue: 1 Pages: 92-96
  • DOI: 10.1002/jbm.b.33180
  • URL: http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1552-4981
  • Peer Reviewed
• [Journal Article] Utility of PAX8 mouse monoclonal antibody in the diagnosis of thyroid, thymic, pleural, and lung tumors: a comparison with polyclonal PAX8 antibody. (2014)
  • Author(s): Toriyama A, Mori T, Sekine S, Yoshida A, Hino O, Tsuta K.
  • Journal Title: Histopathology Volume: On line Issue: 4 Pages: 465-72
  • DOI: 10.1111/his.12405
  • Peer Reviewed
• [Journal Article] Multilayer-omics analysis of renal cell carcinoma, including the whole exome, methylome and transcriptome. (2014)
  • Author(s): Arai E, Sakamoto H, Ichikawa H, Totsuka H, Chiku S, Gotoh M, Mori T, Nakatani T, Ohnami S, Nakagawa T, Fujimoto H, Wang L, Aburatani H, Yoshida T, Kanai Y.
  • Journal Title: Int J Cancer. Volume: On line Issue: 3 Pages: 613-22
  • DOI: 10.1002/cam4.214
  • Peer Reviewed / Open Access
• [Presentation] OLFM4 is upregulated by promotor hypomethylation in head and neck squamous cell carcinoma (2017)
  • Author(s): Takatsugu Suzuki, Taisuke Mori, Hiroshi Yamazaki, Yoshihide Ota
  • Organizer: 第３５回日本口腔腫瘍学会（福岡）
  • Place of Presentation: 福岡国際会議場（福岡県・福岡市）
  • Year and Date: 2017-01-26
  • Invited
• [Presentation] Expression of EpCAM and prognosis in head and neck squamous carcinoma treated by primary radiotherapy (2016)
  • Author(s): Naoya Murakami, Taisuke Mori, Fumihiko Matsumoto, Seiichi Yoshimoto, Satoshi Shima, Keisuke Tsuchida, Tairo Kashihara, Kazuma Kobayashi, Ken Harada, Rei Umezawa, Kana Takahashi, Koji Inaba, Hiroshi Igaki, Yoshinori Ito, Jun Itami
  • Organizer: 日本放射腺腫瘍学会29回学術大会
  • Place of Presentation: 国立京都国際会館（京都府・京都市）
  • Year and Date: 2016-11-25
  • Invited
• [Presentation] Challenges for the application of genome sequence (2016)
  • Author(s): 森 泰昌
  • Organizer: 第27回日本臨床口腔病理学会総会
  • Place of Presentation: 広島大学（広島県・広島市）
  • Year and Date: 2016-08-10
  • Invited
• [Presentation] 頭頸部扁平上皮癌外科治療におけるFFPE検体からのTP53変異解析 (2016)
  • Author(s): 小林 謙也１、森 泰昌２、松本 吉史１、深澤 雅彦１、手島 直則１、松本 文彦１、吉本 世一
  • Organizer: 第40回頭頸部癌学会
  • Place of Presentation: ソニックシティ（埼玉県・さいたま市）
  • Year and Date: 2016-06-09
  • Invited
• [Presentation] 遺伝子の変異と発現変調がおよぼす口腔癌の発症と進行 (2016)
  • Author(s): 森 泰昌
  • Organizer: 第３４回日本口腔腫瘍学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 2016-01-21
  • Invited
• [Presentation] 口腔扁平上皮癌に繋がる早期口腔病変 再建皮弁部に形成された二次性病変の次世代シークエンス解析から (2015)
  • Author(s): 森 泰昌
  • Organizer: 第26回日本臨床口腔病理学会総会
  • Place of Presentation: 札幌市
  • Year and Date: 2015-07-31
  • Invited
• [Presentation] Expression of EpCAM and Prognosis in Head and Neck squamous cell carcinoma (2015)
  • Author(s): Taisuke Mori,
  • Organizer: 4th Asia Head and Neck Oncologic Societies
  • Place of Presentation: 神戸市
  • Year and Date: 2015-06-03
  • Int'l Joint Research
• [Presentation] 上皮異型性と異形成、早期口腔癌の病理組織像とその捉え方 病因と分子生物学的解析からの考察 (2015)
  • Author(s): 森 泰昌
  • Organizer: 第56回日本臨床細胞学会春期大会
  • Place of Presentation: 松江市
  • Year and Date: 2015-05-28
  • Invited
• [Presentation] SOX10 Expression and Genetic Alterations Distinguish Pigmented Ciliary Adenocarcinomas or Adenomas From Uveal Melanomas (2015)
  • Author(s): Sukeda A, Mori T, Aihara Y, Suzuki S Ochiai A,
  • Organizer: USCAP 2015 Annual meeting
  • Place of Presentation: Boston, USA
  • Year and Date: 2015-03-21
• [Presentation] 口腔癌の性質を反映する分子診断 (2015)
  • Author(s): 森 泰昌
  • Organizer: 文部科学省 がんプロフェッショナル養成基盤推進プラン－高度がん医療開発を先導する専門家の養成－4大学合同事業：慶應義塾大学
  • Place of Presentation: 新宿Nビル東京都
  • Year and Date: 2015-02-08
  • Invited
• [Presentation] シンポジウム「頭頸部における稀少がんの病理」 (2014)
  • Author(s): 森 泰昌
  • Organizer: 第59回 日本口腔外科学会総会
  • Place of Presentation: 幕張、千葉
  • Year and Date: 2014-10-17 – 2014-10-19
  • Invited
• [Presentation] レクチャー「早期口腔癌に対する新たな診断法の確立」 (2014)
  • Author(s): 森 泰昌
  • Organizer: 第63回 日本病理学会関東支部会総会
  • Place of Presentation: 昭和大学、東京
  • Year and Date: 2014-06-21
  • Invited
• [Presentation] The Expression of epithelial cell adhesion molecules and prognosis in early stage glottic cancer (2014)
  • Author(s): N. MurakamiT. Mori, S. Yoshimoto, K. Kobayashi, K. Harada,Kitaguchi, S. Sekii, K. Takahashi, K. Yoshio, K. Inaba, M. Morota, M. Sumi, J. Itami
  • Organizer: ESTRO 33 – Annual ESTRO meeting
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2014-04-04 – 2014-04-08
• [Book] 病理と臨床 臨時増刊号 34 癌の分子病理学 頭頸部癌・口腔癌 (2016)
  • Author(s): 森 泰昌
  • Total Pages: 3
  • Publisher: 文光堂
• [Book] 第４版スタンダード病理学 (2016)
  • Author(s): 森 泰昌
  • Total Pages: 3
  • Publisher: 文光堂
• [Book] 腫瘍病理鑑別アトラス 頭頚部腫瘍Ⅱ (2015)
  • Author(s): 森 泰昌、落合 淳志
  • Total Pages: 12
  • Publisher: 文光堂
• [Book] 腫瘍病理鑑別診断アトラス 頭頸部Ⅱ「上気道、咽頭、口腔の表層上皮腫瘍」 (2015)
  • Author(s): 森 泰昌、落合 淳志
  • Total Pages: 6
  • Publisher: 文光堂
• [Book] 腫瘍病理鑑別診断アトラス 頭頸部Ⅱ 「未分化癌」 (2015)
  • Author(s): 森 泰昌、落合 淳志
  • Total Pages: 3
  • Publisher: 文光堂
• [Book] 腫瘍病理鑑別診断アトラス 頭頸部Ⅱ「腺癌」 (2015)
  • Author(s): 森 泰昌、落合 淳志
  • Total Pages: 6
  • Publisher: 文光堂
• [Book] 腫瘍病理鑑別診断アトラス 頭頸部Ⅱ「腫瘍類似疾患」 (2015)
  • Author(s): 森 泰昌、落合 淳志
  • Total Pages: 3
  • Publisher: 文光堂