Development of clinical application method of cancer / stem cell related molecule in head and neck cancer
Project/Area Number |
26460463
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | National Cancer Center Japan |
Principal Investigator |
Mori Taisuke 国立研究開発法人国立がん研究センター, 中央病院, 医員 (00296708)
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Research Collaborator |
Yoshimoto Seiichi
Itami Jun
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 頭頸部癌 / 扁平上皮癌 / 幹細胞関連分子 / 頭頸部腫瘍 / がん幹細胞 / 病理診断 / 頭頸部がん / 幹細胞 / 治療抵抗性 |
Outline of Final Research Achievements |
Head - and - neck squamous cell carcinoma, which overexpresses EpCAM, a stem cell - related molecule, was found to be radioresistant. These can be said to be research results directly linked to clinical practice. The expression of EpCAM was thought to make clinical application possible by using microscopic biopsy specimens usually used for diagnosis of cancer and easy to judge by immunohistological examination.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Impact of microscopic orbital periosteum invasion in orbital preservation surgery.2017
Author(s)
Kobayashi K, Mori T, Matsumoto F, Murakami N, Teshima M, Fukasawa M, Matsumoto Y, Matsumura S, Itami J, Asai M, Yoshimoto S.
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Journal Title
Jpn J Clin Oncol.
Volume: 47
Issue: 4
Pages: 321-327
DOI
Related Report
Peer Reviewed
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[Journal Article] Significance of delayed primary excision in localized nonmetastatic adult head and neck rhabdomyosarcoma2016
Author(s)
Kobayashi K, Matsumoto F, Kodaira M, Mori T, Murakami N, Yoshida A, Maki D, Teshima M, Fukasawa M, Itami J, Asai M, Yoshimoto S.
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Journal Title
Cancer Med.
Volume: 5
Issue: 10
Pages: 2708-2714
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Patterns of recurrence after selective postoperative radiation therapy for patients with head and neck squamous cell carcinoma2016
Author(s)
Murakami N, Matsumoto F, Yoshimoto S, Ito Y, Mori T, Ueno T, Tuchida K, Kashihara T, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Umezawa R, Takahashi K, Inaba K, Igaki H, Itami J
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Journal Title
BMC Cancer
Volume: 16
Issue: 1
Pages: 192-195
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] CIC-rearranged Sarcomas: A Study of 20 Cases and Comparisons With Ewing Sarcomas2016
Author(s)
Yoshida A, Goto K, Kodaira M, Kobayashi E, Kawamoto H, Mori T, Yoshimoto S, Endo O, Kodama N, Kushima R, Hiraoka N, Motoi T, Kawai A.
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Journal Title
Am J Surg Pathol.
Volume: 40
Issue: 3
Pages: 313-23
DOI
Related Report
Peer Reviewed
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[Journal Article] Expression of EpCAM and prognosis in early-stage glottic cancer treated by radiotherapy2014
Author(s)
Murakami N, Mori T, Yoshimoto S, Ito Y, Kobayashi K, Ken H, Kitaguchi M, Sekii S, Takahashi K, Yoshio K, Inaba K, Morota M, Sumi M, Itami J.
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Journal Title
Laryngoscope.
Volume: Nov;124(11):
Issue: 11
Pages: 431-436
DOI
Related Report
Peer Reviewed
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[Journal Article] Multilayer-omics analysis of renal cell carcinoma, including the whole exome, methylome and transcriptome.2014
Author(s)
Arai E, Sakamoto H, Ichikawa H, Totsuka H, Chiku S, Gotoh M, Mori T, Nakatani T, Ohnami S, Nakagawa T, Fujimoto H, Wang L, Aburatani H, Yoshida T, Kanai Y.
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Journal Title
Int J Cancer.
Volume: On line
Issue: 3
Pages: 613-22
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Expression of EpCAM and prognosis in head and neck squamous carcinoma treated by primary radiotherapy2016
Author(s)
Naoya Murakami, Taisuke Mori, Fumihiko Matsumoto, Seiichi Yoshimoto, Satoshi Shima, Keisuke Tsuchida, Tairo Kashihara, Kazuma Kobayashi, Ken Harada, Rei Umezawa, Kana Takahashi, Koji Inaba, Hiroshi Igaki, Yoshinori Ito, Jun Itami
Organizer
日本放射腺腫瘍学会29回学術大会
Place of Presentation
国立京都国際会館(京都府・京都市)
Year and Date
2016-11-25
Related Report
Invited
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[Presentation] The Expression of epithelial cell adhesion molecules and prognosis in early stage glottic cancer2014
Author(s)
N. MurakamiT. Mori, S. Yoshimoto, K. Kobayashi, K. Harada,Kitaguchi, S. Sekii, K. Takahashi, K. Yoshio, K. Inaba, M. Morota, M. Sumi, J. Itami
Organizer
ESTRO 33 – Annual ESTRO meeting
Place of Presentation
Vienna, Austria
Year and Date
2014-04-04 – 2014-04-08
Related Report
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