Enhancement of invasiveness of cancer cells by hypoxia-induced expression of HOX genes

• Project/Area Number: 26460466
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Health Sciences University of Hokkaido (2016-2017); Hokkaido University (2014-2015)
• Principal Investigator: HAMADA Jun-ichi 北海道医療大学, 看護福祉学部, 教授 (50192703)
• Co-Investigator(Renkei-kenkyūsha): IIZASA Hisashi 島根大学, 医学部, 准教授 (80306662)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: がん転移 / ホメオボックス遺伝子 / HOX / 浸潤 / 低酸素 / 転移

Outline of Final Research Achievements

We have been demonstrating that dysregulated expression of HOX genes, which play an important role in giving cells positional information, influences invasive and metastatic ability of cancer cells. In this study, we revealed that hypoxia-induced expression of HOXD3 gene, one of the HOX genes, in cancer cells enhanced invasive and metastatic ability, and suggested that the cancer cells overexpressing HOXD3 had an advantage to adapt themselves to hypoxic condition.

Research Products

• [Journal Article] Reactivating p53 functions by suppressing its novel inhibitor iASPP: a potential therapeutic opportunity in p53 wild-type tumors (2015)
  • Author(s): Dong, P., Ihira, K., Hamada, J., Watari, H., Yamada, T., Hosaka, M., Hanley, S.J.B., Kudo, M. and Sakuaragi, N.
  • Journal Title: Oncotarget Volume: 6 Pages: 19968-19975
  • Peer Reviewed / Open Access
• [Presentation] New Driver Candidate for Mets (2015)
  • Author(s): 浜田淳一・越川直彦
  • Organizer: 第24回日本がん転移学会学術集会
  • Place of Presentation: シティプラザ大阪（大阪府・大阪市）
  • Year and Date: 2015-07-23
• [Presentation] 低酸素刺激によって増強するヒト悪性胸膜中皮腫細胞の運動・浸潤能におけるHIF1およびMUC1の役割 (2015)
  • Author(s): 項慧慧・ゴウダルジホウマヌ・飯笹久・坂田健一郎・樋田泰浩・柳原五吉・久保貴紀・中川宏治・小林正伸・入村達郎・浜田淳一
  • Organizer: 第24回日本がん転移学会学術集会
  • Place of Presentation: シティプラザ大阪（大阪府・大阪市）
  • Year and Date: 2015-07-23
• [Presentation] HOX遺伝子の発現異常からみたがんの浸潤・転移 (2014)
  • Author(s): 浜田淳一
  • Organizer: 鳥取大学発癌病理学セミナー
  • Place of Presentation: 鳥取大学医学部（鳥取・米子）
  • Year and Date: 2014-12-19
  • Invited
• [Presentation] HOX遺伝子の発現異常とがんの転移・浸潤 (2014)
  • Author(s): 浜田淳一
  • Organizer: 東北大学病院がんセミナー
  • Place of Presentation: 東北大学病院（宮城・仙台）
  • Year and Date: 2014-09-11
  • Invited