| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We established an experimental model system for assessing atherosclerotic lesion formation in vivo using new impaired glucose tolerance-prone and -resistant mice. We confirmed that arteriosclerotic lesion formation is accelerated in the prone mice as compared to the resistant mice. In addition, the accelerated lesion formation in the prone mice was suppressed by metformin. We also established another experimental model system for evaluating the effect of repetitive blood glucose spikes more directly on atherosclerotic lesion formation, and demonstrated that oral glucose administration-induced blood glucose fluctuation accelerates the lesion formation in mice. These results clearly demonstrate that impaired glucose tolerance actually evokes atherosclerotic lesion formation in vivo.
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