Molecular mechanisms underlying exogenous sterol uptake in pathogenic fungus
| Project/Area Number |
26460541
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Ryukoku University (2015-2016)
National Institute of Infectious Diseases (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | カンジダ / ABCトランスポーター / ステロール / 病原性 / トランスポーター / 病原真菌 / Candida / 抗真菌薬 |
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| Outline of Final Research Achievements |
The pathogenic fungus Candida glabrata, a commensal yeast that is resident in the human gastrointestinal tract, causes disseminated infection in immune-compromized host. Although C. glabrata has been thought to take up extracellular sterols in the host body, its physiological significance and molecular mechanisms have not been elucidated. From the analysis of the gene-disrupted C. glabrata strain, we demonstrated that the sterol transporter Aus1p and the cell wall mannoprotein Tir3p were essential for sterol uptake, and the expression levels of AUS1 and TIR3 were up-regulated under the iron deficiency condition similar to blood stream infection.
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Report
(4 results)
Research Products
(7 results)
