| Project/Area Number |
26460643
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Laboratory medicine
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
WATANABE Kanako 新潟大学, 医歯学系, 准教授 (80626094)
|
|---|
| Research Collaborator |
WATANABE Hisami 新潟大学, 医歯学系, 特任教授 (50143756)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
|---|
| Keywords | エストロゲン / 自己免疫性肝炎 / 肝樹状細胞 / IL-10 / IL-12 / エストロゲン受容体 / エストロゲン受容体阻害 / 17β-estradiol / エストロゲン受容体α鎖 |
|---|
| Outline of Final Research Achievements |
Autoimmune hepatitis is often found in middle-aged women whose estrogen level is low.Therefore, we investigated the effects of estrogen level on the onset or the progression of autoimmune hepatitis. We examined hepatic dendritic cells (DCs) with mice model. Our results showed that estrogen can suppress autoimmune liver injury because hepatic plasmacytoid DCs (pDCs) increase IL-10 production by estrogen receptor α chain. On the other hand, an estrogen blockade or an ovariectomy decreased such effects of estrogen. At the same time, hepatic myeloid DCs (mDCs) were activated and they increased production of IL-12p70 as well as TNFα. In this way, it is considered that estrogen affords the key to understand the onset of autoimmune hepatitis and its progression. From the view point of DCs, a shift of two types of hepatic DC subpopulations, pDCs or mDCs in the liver, could provide another clue to autoimmune hepatitis.
|
