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The effects of estrogen and hepatic dendritic cells on the onset of autoimmune hepatitis.

Research Project

Project/Area Number 26460643
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory medicine
Research InstitutionNiigata University

Principal Investigator

Tomiyama Chikako  新潟大学, 医歯学系, 准教授 (80359702)

Co-Investigator(Renkei-kenkyūsha) WATANABE Kanako  新潟大学, 医歯学系, 准教授 (80626094)
Research Collaborator WATANABE Hisami  新潟大学, 医歯学系, 特任教授 (50143756)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsエストロゲン / 自己免疫性肝炎 / 肝樹状細胞 / IL-10 / IL-12 / エストロゲン受容体 / エストロゲン受容体阻害 / 17β-estradiol / エストロゲン受容体α鎖
Outline of Final Research Achievements

Autoimmune hepatitis is often found in middle-aged women whose estrogen level is low.Therefore, we investigated the effects of estrogen level on the onset or the progression of autoimmune hepatitis. We examined hepatic dendritic cells (DCs) with mice model. Our results showed that estrogen can suppress autoimmune liver injury because hepatic plasmacytoid DCs (pDCs) increase IL-10 production by estrogen receptor α chain. On the other hand, an estrogen blockade or an ovariectomy decreased such effects of estrogen. At the same time, hepatic myeloid DCs (mDCs) were activated and they increased production of IL-12p70 as well as TNFα. In this way, it is considered that estrogen affords the key to understand the onset of autoimmune hepatitis and its progression. From the view point of DCs, a shift of two types of hepatic DC subpopulations, pDCs or mDCs in the liver, could provide another clue to autoimmune hepatitis.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2016 2014

All Presentation (2 results)

  • [Presentation] The blockade of estrogen receptors on dendritic cells exacerbates autoimmune hepatitis.2016

    • Author(s)
      Chikako TOMIYAMA, Hisami WATANABE
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] Estrogen inhibited liver injury in Concanavalin A-induced hepatitis mice. ―Focused on dendritic cells in the liver―2014

    • Author(s)
      五十島亜美、富山智香子、渡部久実
    • Organizer
      第43回日本免疫学会総会・学術総会
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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