| Project/Area Number |
26460646
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
川端 健一 山梨大学, 総合研究部, 講師 (30345706)
渡辺 一広 山梨大学, 総合研究部, 病院助教 (50535549)
中村 貴光 山梨大学, 総合研究部, 助教 (60377512)
藤岡 大佑 山梨大学, 総合研究部, 助教 (70377513)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | RNA診断 / バイオマーカー / 虚血性心疾患 / 不安定プラーク / RNA / 循環器病学 / ＲＮＡ診断 |
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| Outline of Final Research Achievements |
To identify novel mRNA biomarker from peripheral blood for ischemic heart disease, mRNA expression pattern was compared with patients with normal coronary and patients with acute coronary syndrome. On TLR2, TLR4, CCR2，Annexin A1, FPR2, and TREM1 mRNA, expression levels were statistically different between patients with normal coronary and patients with acute coronary syndrome. The first to third genes were already reported well, however forth to sixth genes are not yet less reported. The Annexin A1, FPR2, and TREM1 mRNA from human peripheral blood might be useful biomarker for ischemic heart disease.
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