| Project/Area Number |
26460657
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Tokai University |
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Principal Investigator |
ASAI Satomi 東海大学, 医学部, 准教授 (60365989)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYACHI Hayato 東海大学, 医学部, 教授 (20174196)
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| Research Collaborator |
YOSHIHARA Eisaku 東海大学, 工学部, 客員准教授
OHSHIMA Toshio 東海大学, 医学部付属病院, 臨床検査技師
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 緑膿菌 / アシネトバクター / 多剤耐性菌 / 薬剤排出ポンプ / Bam / 簡易迅速検査 / 感染制御 / real time RT-PCR / 簡易検査 / 排出ポンプ / 多剤耐性 / 薬剤耐性 / 耐性獲得機構 |
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| Outline of Final Research Achievements |
The mutations in the genes responsible for the development of antimicrobial resistance were investigated in the drug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii which showed resistance to at least 2 among imipenem, amikacin and ciprofloxacin. As a result, the contribution of the efflux pumps was found involved in almost all drug-resistant strains. On the other hand, the complex protein which supplied s peptides for efflux pumps did not significantly increased.
The monitoring of the efflux pumps of P. aeruginosa and Acinetobacter baumannii was suggested to be useful in infection control.
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