• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

FGF23-Klotho is associated with the progression of a disease of aging matter lesions

Research Project

Project/Area Number 26460751
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

OZAKI ETSUKO  京都府立医科大学, 医学(系)研究科(研究院), 助教 (00438219)

Co-Investigator(Kenkyū-buntansha) 渡辺 能行  京都府立医科大学, 医学(系)研究科(研究院), 教授 (00191809)
渡邉 功  京都府立医科大学, 医学(系)研究科(研究院), 助教 (10636525)
松井 大輔  京都府立医科大学, 医学(系)研究科(研究院), 助教 (20613566)
栗山 長門  京都府立医科大学, 医学(系)研究科(研究院), 准教授 (60405264)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsFGF23 / BAP / UCAR / non-CKD / TRACP-5b / 骨代謝
Outline of Final Research Achievements

We investigated whether Phosphate (P) load into circulation might cause renal damage in non-CKD women. This cross-sectional study included 1,094 non-CKD Japanese women. Fibroblast growth factors (FGF)-23 as the parameters for P load, bone alkaline phosphatase (BAP) as the bone metabolic marker, and urinary albumin-to-creatinine ratio (UACR) as an early marker for renal damage were measured.
Postmenopausal women exhibited significantly higher levels of serum P, FGF-23, BAP, and UACR and significantly lower eGFR than in premenopausal women. In premenopausal women, although serum FGF-23 failed to correlate with log UACR, multiple regression analysis elucidate FGF-23 to associate significantly in a positive manner with log UACR. In postmenopausal women, multiple regression analysis confirmed the significant and independent association between serum BAP and log UACR.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (4 results)

  • [Journal Article] Association between loss of bone mass due to short sleep and leptin-sympathetic nervous system activity2017

    • Author(s)
      Nagato Kuriyama, Masaaki Inaba, Etsuko Ozaki, Yutaro Yoneda, Daisuke Matsui, Kanae Hashiguchi, Teruhide Koyama, Komei Iwai, Isao Watanabe, Rika Tanaka, Chie Omichi, Shigeto Mizuno, Masao Kurokawa, Motoyuki Horii, Fumitoshi Niwa, Koichi Iwasa, Shinsuke Yamada, Yoshiyuki Watanabe
    • Journal Title

      Archives of Gerontology and Geriatrics

      Volume: 70 Pages: 201-208

    • DOI

      10.1016/j.archger.2017.02.005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 一般壮年男性の血清25(OH)D濃度と食品摂取頻度の関連についての検討2016

    • Author(s)
      尾崎悦子
    • Organizer
      第18回日本骨粗鬆症学会
    • Place of Presentation
      仙台 勝山館
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 一般壮年者における皮質骨厚と骨格筋量の連関2016

    • Author(s)
      栗山長門
    • Organizer
      第18回日本骨粗鬆症学会
    • Place of Presentation
      仙台 勝山館
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 橈骨皮質骨厚および海綿骨骨密度と骨代謝調節因子の検討2015

    • Author(s)
      尾崎悦子
    • Organizer
      第17回日本骨粗鬆症学会
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 日本人non-CKDにおける血清FGF-23濃度の決定因子と尿中アルブミン排泄について2015

    • Author(s)
      尾崎悦子
    • Organizer
      第26回日本腎性骨症研究会
    • Place of Presentation
      東京 品川プリンスホテル
    • Year and Date
      2015-02-21
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi