Blood Pressure Variability and Functional Outcome After Acute Ischemic Stroke: Fukuoka Stroke Registry

• Project/Area Number: 26460756
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Kurume University
• Principal Investigator: Fukuda Kenji 久留米大学, 医学部, 講師 (10624512)
• Co-Investigator(Kenkyū-buntansha): 甲斐 久史 久留米大学, その他部局等, 教授 (60281531) ; 北園 孝成 九州大学, 医学研究院, 教授 (70284487) ; 鴨打 正浩 九州大学, 医学研究院, 教授 (80346783)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 血圧変動 / 脳梗塞 / 予後 / 機能予後

Outline of Final Research Achievements

The relationship between blood pressure (BP) variability and functional outcome in patients with acute ischemic stroke remains unclear. This study aimed to elucidate whether in-hospital day-by-day BP variability is associated with functional outcome after acute ischemic stroke. Using the Fukuoka Stroke Registry, we included 2566 patients with a first-ever ischemic stroke who had been functionally independent before the onset and were hospitalized within 24 hours. After adjustment for multiple confounding factors, day-by-day BP variability during the subacute stage (4-10 days after onset) was independently associated with a poor functional outcome. In contrast, no association was found between indices of BP variability during the acute stage and functional outcome after adjusting for potential confounders. These data suggest that intraindividual day-by-day BP variability during the subacute stage is associated with the 3-month functional outcome after acute ischemic stroke.

Research Products

• [Journal Article] Day-by-Day Blood Pressure Variability and Functional Outcome After Acute Ischemic Stroke: Fukuoka Stroke Registry (2015)
  • Author(s): Fukuda K, Kai H, Kamouchi M, Hata J, Ago T, Nakane H, Imaizumi T, Kitazono T
  • Journal Title: Stroke Volume: 46 Issue: 7 Pages: 1832-1839
  • DOI: 10.1161/strokeaha.115.009076
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Poor Blood Pressure Control and Severe Coronary Artery Lesions Are Risks of Cerebral Microbleeds in Patients With Coronary Artery Disease During Antiplatelet Therapy (2015)
  • Author(s): 岩元美子
  • Organizer: American Heart Association 2015
  • Place of Presentation: オーランド（米国）
  • Year and Date: 2015-11-09
• [Presentation] 高齢者冠動脈疾患における拡張期血圧低値は心血管死亡の確立した危険因子か？ (2015)
  • Author(s): 甲斐久史
  • Organizer: 第38回日本高血圧学会総会
  • Place of Presentation: 愛媛県県民文化会館（松山市）
  • Year and Date: 2015-10-08
• [Presentation] Within-individual day-by-day blood pressure variability during subacute stage predicts functional and long-term survival outcomes in ischemic stroke patients: Fukuoka Stroke Registry (2014)
  • Author(s): Kenji Fukuda, Hisashi Kai, Masahiro Kamouchi, Jun Hata, Testsuo Ago, Tutomu Imaizumi, Takanari Kitazono
  • Organizer: European Society of Cardiology Congress 2014
  • Place of Presentation: スペイン バルセロナ
  • Year and Date: 2014-08-30 – 2014-09-03
• [Remarks] Fukuoka Stroke Registry：福岡脳卒中データベース研究
  • URL: http://www.fukuoka-stroke.net