Influence of nicotine metabolism and other factors on the withdrawal symptoms
Project/Area Number |
26460758
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Epidemiology and preventive medicine
|
Research Institution | Gunma University (2016-2017) Kanagawa University of Human Services (2015) National Institute of Public Health (2014) |
Principal Investigator |
Oba Shino 群馬大学, 大学院保健学研究科, 教授 (70397321)
|
Research Collaborator |
Ino Toshihiro
Inaba Yohei
|
Project Period (FY) |
2014-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | ニコチン代謝能 / 酸化ストレス / 禁煙 / 酸化ストレスマーカー / cortisol / epinephrine / ニコチン依存 / 離脱症状 / ストレス |
Outline of Final Research Achievements |
We estimated the nicotine metabolism from the values of nicotine and trans-3’-hydroxycotinine among patients who started the smoking cessation treatment. The difference of the urinary cotinine levels between the measures at the beginning of the treatment and 2 weeks after the treatment was evaluated. The interaction term between the level of nicotine metabolism and time was calculated for the analysis. The cotinine level was largely decreased 2 weeks after the treatment, regardless the level of nicotine metabolism. The interaction effects between oxidative stress levels and time were implied, although they were not statistically significant.
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Report
(5 results)
Research Products
(4 results)