Lipid management based on gender difference for prevention of cardiovascular disease

• Project/Area Number: 26460789
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Takegami Misa 国立研究開発法人国立循環器病研究センター, 研究開発基盤センター, 室長 (50456860)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 脂質管理 / 循環器疾患 / コホート研究 / 地域住民

Outline of Final Research Achievements

Dyslipidemia is an established risk factor for cardiovascular disease, but the existence of several lipid measures for preventive cardiovascular disease may make interpretation difficult for residents. In addition, changes in serum lipid levels with aging differ greatly between men and women, and thus efficient and appropriate lipid management based on sex is necessary. In this study, we examined the relationship between lipid measures and cardiovascular disease, stratified by sex group. Low-density lipoprotein (LDL) cholesterol, total cholesterol, and ratio of LDL to high-density lipoprotein cholesterol was associated with ischemic heart disease onset in men, but no association was found in women. Low LDL cholesterol is a risk factor for cerebral hemorrhage in women; this suggests the need for further studies that explore the optimal cut-off point for lipid measures, including other factors, such as biomarkers and lifestyle, in lipid management for women.

Research Products

• [Journal Article] Diabetes and lifetime risk of stroke and subtypes in an urban middle-aged population. (2017)
  • Author(s): Turin TC, Okamura T, Rumana N, Afzal AR, Watanabe M, Higashiyama A, Nakao YM, Nakai M, Takegami M, Nishimura K, Kokubo Y, Okayama A, Miyamoto Y.
  • Journal Title: J Diabetes Complications Volume: 31 Issue: 5 Pages: 831-835
  • DOI: 10.1016/j.jdiacomp.2017.02.002
  • Peer Reviewed
• [Journal Article] Risk for metabolic diseases in normal weight individuals with visceral fat accumulation: a cross-sectional study in Japan (2017)
  • Author(s): Yukako Tatsumi, Yoko M Naka, Izuru Masuda, Aya Higashiyama, Misa Takegami, Kunihiro Nishimura, Makoto Watanabe, Takayoshi Ohkubo, Tomonori Okamura, Yoshihiro Miyamoto
  • Journal Title: BMJ Open Volume: なし Issue: 1 Pages: e013831-e013831
  • DOI: 10.1136/bmjopen-2016-013831
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Impact of hypertension on the lifetime risk of coronary heart disease (2016)
  • Author(s): Chowdhury Turin T, Okamura T, Raheen Afzal A, Rumana N, Watanabe M, Higashiyama A, Nakao YM, Nakai M, Takegami M, Nishimura K, Kokubo Y, Okayama A, Miyamoto Y.
  • Journal Title: Hypertens Res Volume: ２３ Issue: 7 Pages: 548-51
  • DOI: 10.1038/hr.2016.23
  • Peer Reviewed
• [Journal Article] Low testosterone levels and reduced kidney function in Japanese adult men: the LOHAS study. (2016)
  • Author(s): Kurita N, Horie S, Yamazaki S, Otani K, Sekiguchi M, Onishi Y, Takegami M, Ono R, Konno S, Kikuchi S, Fukuhara S.
  • Journal Title: Journal of the American Medical Directors Association Volume: 17 Issue: 4 Pages: 371.e1-371.e6
  • DOI: 10.1016/j.jamda.2016.01.011
  • Peer Reviewed
• [Journal Article] Hypertension and lifetime risk of stroke (2016)
  • Author(s): Turin TC, Okamura T, Afzal AR, Rumana N, Watanabe M, Higashiyama A, Nakao Y, Nakai M, Takegami M, Nishimura K, Kokubo Y, Okayama A, Miyamoto Y
  • Journal Title: J Hypertens Volume: ３４ Issue: 1 Pages: 116-22
  • DOI: 10.1097/hjh.0000000000000753
  • Peer Reviewed
• [Presentation] Development of Cardiovascular Disease Risk Prediction Model in the Population-based Prospective Cohort Study of Japan: The Suita Study. (2017)
  • Author(s): Nakai M, Nakamura F, Nishimura K, Watanabe M, Kokubo Y, Takegami M, Nakao Y, Higashiyama A, Okamura T, Miyamoto Y.
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2017-03-17
• [Presentation] 都市部コホート研究における循環器疾患のリスクスコアの開発：吹田研究． (2017)
  • Author(s): 中井陸運, 中村文明, 西村邦宏, 渡邉至, 小久保喜弘, 竹上未紗, 中尾葉子, 東山綾, 岡村智教，宮本恵宏．
  • Organizer: 第27回日本疫学会学術総会
  • Place of Presentation: 甲府
  • Year and Date: 2017-01-25
• [Presentation] 低LDL コレステロールは脳内出血発症のリスク因子である：吹田研究より． (2016)
  • Author(s): 竹上未紗, 岡村智教，渡邉至, 東山綾, 中尾葉子, 渡邉琢也, 辰巳友佳子, 小久保喜弘, 宮本恵宏．
  • Organizer: 第48回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-07-14
• [Presentation] Usefulness of LDL-C to HDL-C ratio in assessing risk of cardiovascular diseases: The Suita study. (2015)
  • Author(s): Takegami M, Watanabe M, Higashiyama A, Tatsumi Y, Nakai M, Nakao YM, Nishimura K, Kokubo Y, Miyamoto Y.
  • Organizer: 8th European public health conference
  • Place of Presentation: Milan
  • Year and Date: 2015-10-14
  • Int'l Joint Research
• [Presentation] Stroke risk assessment tool including a status of chronic kidney disease category improve a predictive capability: The Suita study. (2015)
  • Author(s): Nakamura F, Nishimura K, Watanabe M, Kokubo Y, Higashiyama A, Takegami M, Nakao Y, Nakai M, Okamura T, Miyamoto Y.
  • Organizer: 8th European public health conference
  • Place of Presentation: Milan
  • Year and Date: 2015-10-14
  • Int'l Joint Research
• [Presentation] 虚血性心疾患スクリーニングを目的としたNon-HDLコレステロールのカットオフ値の検討：吹田研究． (2015)
  • Author(s): 4.杉山大典，岡村智教，竹上未紗，渡邉至，小久保喜弘，東山綾，中尾葉子，桑原和代，宮本恵宏．
  • Organizer: 第47回日本動脈硬化学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2015-07-09
• [Presentation] Usefulness of Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio in assessing risk of the incidence of cardiovascular diseases: The Suita study (2015)
  • Author(s): Misa Takegami, Makoto Watanabe, Takashi Kobayashi, Michikazu Nakai, Yoko Nakao, Aya Higashiyama, Kunihiro Nishimura, Yoshihiro Kokubo, Yoshihiro Miyamoto
  • Organizer: 日本循環器学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Usefulness of the low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio in assessing the risk of cardiovascular disease. (2015)
  • Author(s): Takegami M, Watanabe M, Kobayashi T, Nakao YM, Higashiyama A, Nishimura K, Kokubo Y, Miyamoto Y.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24