An epidemiological study on the relation of iron in the body with subsequent changes in biomarkers

• Project/Area Number: 26460850
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Hokkaido University
• Principal Investigator: NAKAMURA Koshi 北海道大学, 医学研究科, 准教授 (80422898)
• Co-Investigator(Renkei-kenkyūsha): NAKAGAWA Hideaki 金沢医科大学, 医学部, 教授 (00097437) ; SAKURAI Masaru 金沢医科大学, 医学部, 准教授 (90397216) ; MORIKAWA Yuko 金沢医科大学, 看護学部, 教授 (20210156) ; NAGASAWA Shin-ya 金沢医科大学, 医学部, 講師 (30510341)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: フェリチン / 血糖 / インスリン / 縦断研究 / 鉄動態 / 身体指標

Outline of Final Research Achievements

We investigated the relation of serum ferritin with subsequent changes in biomarkers associated with glucose metabolism among 575 normoglycemic men without iron overload disorders. The subsequent changes in fasting blood glucose, insulin and HOMA-IR after 3 years were grater in subjects having lower levels of serum ferritin after adjustment for body mass index and other potential confounding factors. However, HOMA-β was similar across serum ferritin levels. Elevated serum ferritin levels may worsen glucose metabolism through insulin resistance among normoglycemic Japanese men without iron overload disorders.

Research Products

• [Journal Article] Serum Ferritin, Insulin Resistance, and β-cell Dysfunction: A Prospective Study in Normoglycemic Japanese Men. (2017)
  • Author(s): Nakamura K, Sakurai M, Morikawa Y, Nagasawa SY, Miura K, Ishizaki M, Kido T, Naruse Y, Nakashima M, Nogawa K, Suwazono Y, Nakagawa H.
  • Journal Title: Experimental and Clinical Endocrinology & Diabetes Volume: 125 Issue: 01 Pages: 12-20
  • DOI: 10.1055/s-0042-118175
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 血清フェリチンと糖代謝に関する指標との関連の縦断的検討. (2017)
  • Author(s): 中村幸志, 櫻井勝, 森河裕子, 長澤晋哉, 三浦克之, 石崎昌夫, 城戸照彦, 成瀬優知, 中島素子, 能川和浩, 諏訪園靖, 中川秀昭.
  • Organizer: 第27回日本疫学会学術総会
  • Place of Presentation: ベルクラシック甲府（山梨県甲府市）
  • Year and Date: 2017-01-25