| Project/Area Number |
26460905
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Osaka University |
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Principal Investigator |
OGURO RYOSUKE 大阪大学, 医学部附属病院, 特任助教(非常勤) (70630705)
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| Co-Investigator(Kenkyū-buntansha) |
樂木 宏実 大阪大学, 医学系研究科, 教授 (20252679)
神出 計 大阪大学, 医学系研究科, 教授 (80393239)
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| Co-Investigator(Renkei-kenkyūsha) |
GONDO Yasuyuki 大阪大学, 人間科学研究科, 准教授 (40250196)
IKEBE Kazunori 大阪大学, 歯学系研究科, 准教授 (70273696)
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| Research Collaborator |
RYUNO Hirochika
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 高齢者 / メタボリック症候群 / 遺伝子多型 / ADAR遺伝子 / 脂質異常症 / ADAR |
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| Outline of Final Research Achievements |
A single nucleotide polymorphism of the adenosine deaminase, RNA-specific (ADAR) gene “rs2805533 (A/G) ” was significantly associated with serum triglyceride(TG) level, and a criteria for metabolic syndrome (TG≧150mg/dl and/or HDL < 40mg/dl ) in 70 ± 1 elderly. Three years later, rs2805533 was also significantly associated with serum TG level, serum high density lipoprotein (HDL) cholesterol level, and a criteria for metabolic syndrome (TG≧150mg/dl and/or HDL < 40mg/dl ) in 73 ± 1 elderly. In this study population, the subject with G allele had higher risk for dyslipidemia. In this cohort analysis, rs2805533 was significantly associated with the delta of HDL cholesterol level (ΔHDL) between 70(±1) and 73(±1) years, and the subject with GG genotypes had lower HDL cholesterol level than AA and AG genotypes.
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