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Predicting 72-hour mortality among patients with extremely outlier values of laboratory tests: Case-controlled cross sectional studies and clinical values

Research Project

Project/Area Number 26460916
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionJichi Medical University

Principal Investigator

Sugawara Hitoshi  自治医科大学, 医学部, 教授 (80285808)

Project Period (FY) 2014-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords超極端外れ値 / 臨床検査データ二次利用 / ビックデータ / 予後予測モデル / 随時血糖500 mg/dL以上 / AST 3,000 U/L以上 / C反応性蛋白 40 mg/dL以上 / 血清無機リン10 mg/dL以上 / 臨床検査値 / ビッグデータ / 72時間後転帰 / 高血糖 > 500 mg/dL / CRP > 40 mg/dL / 高リン血症 > 10 mg/dL / AST > 3,000 U/L / 臨床検査二次利用 / 極端外れ値 / 生化学検査 / 予後リスク推定回帰式 / ロジスティック解析 / 臨床検査データ / 外れ値 / 短期的予後 / 単回帰分析 / 重回帰分析 / C統計量 / ロジスティック分析 / 予後 / 臨床検査 / 極端値 / プライマリ・ケア / 超極端値 / 診断アルゴリズム / 総合診療
Outline of Final Research Achievements

The 72-hour mortality rates (%) of 100 cases with the extremely high outlier laboratory data were blood gas carbon dioxide (67.9), lactate (63.0), serum inorganic phosphorus (IP; 47.1), lactate dehydrogenase (LD) & ammonia (42.9), aspartate aminotransferase (AST; 39.0), D-dimer (30.0), and blood urea nitrogen (BUN; 26.9). The mortality rates of 100 cases with the extremely low outlier laboratory data were blood gas pH (100), base excess (100), bicarbonate (44.4), fibrinogen (39.7), antithrombin III (26.5), and random plasma glucose (22.6). The predicting models of 72-hour mortality were explained respectively as follows, random plasma glucose (>500 mg/dL) by CK and albumin, AST (>3,000 U/L) by alkaline phosphatase, sodium and IP, C-reactive protein (CRP; >40 mg/dL) by age, IP and BUN, IP (>10 mg/dL) by age, LD and total cholesterol. For details, please refer to the research report.

Academic Significance and Societal Importance of the Research Achievements

本研究では、日常診療で検査され蓄積される血液生化学データベースを二次利用することにより、臨床検査項目で超極端外れ値を示した患者の72時間後死亡率とその予測モデルを創出できた。予測モデルは、対象とした検査項目以外の複数の検査項目の組合せで説明できた。この結果から、極端な検査値異常に遭遇した場合にも,短期的な予後を予測するための解析方法が明らかとなり、プライマリー・ケア領域の医療の質を改善することが期待できる。また、医療機関の臨床検査データベースを二次利用することよる医療の質改善のためのResearch Patient Data Registryの整備に一石を投じる意義も見いだすことができた。

Report

(7 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (92 results)

All 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article (34 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 31 results,  Open Access: 30 results,  Acknowledgement Compliant: 1 results) Presentation (46 results) (of which Int'l Joint Research: 3 results) Remarks (12 results)

  • [Journal Article] Predicting 72-hour mortality in patients with the extremely high value of random plasma glucose: A case-control cross-sectional study.2020

    • Author(s)
      Tamami Watanabe, Hitoshi Sugawara, Kai Saito, Akira Ishii, Takahiko Fukuchi, Kiyoka Omoto.
    • Journal Title

      Medicine

      Volume: Submitted

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predicting 72-hour mortality in patients with an extremely high value of serum C-reactive protein over 40 mg/dL: A case-controlled cross-sectional study2020

    • Author(s)
      Kai Saito, Hitoshi Sugawara, Tamami Watanabe, Akira Ishii, Takahiko Fukuchi
    • Journal Title

      PLOS One

      Volume: Submitted

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predicting 72-hour mortality in patients with severe hyperphosphatemia over 10 mg/dL: A case-controlled cross-sectional study.2020

    • Author(s)
      Kai Saito, Susumu Ookawara, Hitoshi Sugawara, Tamami Watanabe, Akira Ishii, Takahiko Fukuchi
    • Journal Title

      Journal of Critical Medicine

      Volume: Submitted

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Importance of actively suspecting intracranial hypotension with diagnostic imaging prior to lumbar puncture.2020

    • Author(s)
      Hori, Hiroshi; Hanako, Yoshihara; Fukuchi, Takahiko; Hitoshi, Sugawara
    • Journal Title

      Journal of General and Family Medicine

      Volume: - Issue: 5 Pages: 195-196

    • DOI

      10.1002/jgf2.329

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fat ring sign and tumoral pseudocapsule sign in idiopathic mesenteric panniculitis complicated by protein-losing enteropathy.2020

    • Author(s)
      Hori, Hiroshi; Fukuchi, Takahiko; Hitoshi, Sugawara
    • Journal Title

      Journal of General and Family Medicine

      Volume: 00 Issue: 4 Pages: 1-2

    • DOI

      10.1002/jgf2.318

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] At-a-glance diagnosis of postherpetic abdominal pseudohernia.2020

    • Author(s)
      Hori, Hiroshi; Fukuchi, Takahiko; Hitoshi, Sugawara
    • Journal Title

      International Journal of Infectious Diseases

      Volume: - Pages: 371-372

    • DOI

      10.1016/j.ijid.2020.03.079

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Imported brucellosis in the era of dramatically increasing immigrants and foreign travelers from endemic areas: occupational hazards of secondary infection among laboratory technicians in a nonendemic country.2020

    • Author(s)
      Takahiko Fukuchi, Nobue Yanagihara, Koichi Imaoka, Hitoshi Sugawara
    • Journal Title

      International Medical Case Reports Journal

      Volume: 12 Pages: 313-317

    • DOI

      10.2147/imcrj.s224831

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapid Progression of Lung Cancer Following Emergency Caesarean Section Led to Postpartum Acute Respiratory Failure2019

    • Author(s)
      Watanabe, T., Yamashita, T., Sugawara, H., Fukuchi, T., Ishii, A., Nagai, Y., Oyanagi, F., Koyama, S., Ushijima J., Takagi, K., and Tanaka, A.
    • Journal Title

      Internal Medicine

      Volume: 58 Issue: 7 Pages: 991-997

    • DOI

      10.2169/internalmedicine.1105-18

    • NAID

      130007622169

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2019-04-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 72-hour mortality prediction in patients with the extremely high serum aspartate aminotransferase > 3,000 U/L: A retrospective case-controlled cross-sectional study.2019

    • Author(s)
      Kai Saito, Hitoshi Sugawara, Tamami Watanabe, Akira Ishii, Takahiko Fukuchi.
    • Journal Title

      Scientific Reports

      Volume: Submitted

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acute splenic infarction presenting as an unusual manifestation of essential thrombocythemia with normal platelet count.2019

    • Author(s)
      Yoshida, K., Kurihara I., Fukuchi, T., and Sugawara, H
    • Journal Title

      BMJ Case Reports

      Volume: 12

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unclassified Vasculitis with Episcleritis, Thrombophlebitis, Deep Vein Thrombosis, Pulmonary Vasculitis, and Intracranial Vasculitis: An Autopsy Case Report.2019

    • Author(s)
      Watanabe, E., Tanaka, A., Sugawara, H., Nishina, K., Yaba, H., Gono, T., and Terai, C
    • Journal Title

      American Journal of Case Reports

      Volume: 20 Pages: 886-895

    • DOI

      10.12659/ajcr.915527

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acute syphilitic meningitis in an HIV-negative patient.2019

    • Author(s)
      Saori Minato, Takeshi Yamashita, Katsuyuki Yoshida, Ai Kawamura, Tamami Watanabe, Akira Ishii, Takahiko Fukuchi, Hitoshi Sugawara, Masaaki Kawase, Toshio Demitsu
    • Journal Title

      Jichi Medical University Journal

      Volume: 41 Pages: 29-33

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vogt-Koyanagi-Harada Disease Associated with Influenza A Virus Infection2018

    • Author(s)
      Yoshino N, Kawamura A, Ishii A, Yoshida K, Watanabe T, Yamashita T, Fukuchi T, Toyoda F, Kakehashi A, Sugawara H
    • Journal Title

      Internal Medicine

      Volume: 57 Issue: 11 Pages: 1661-1665

    • DOI

      10.2169/internalmedicine.9819-17

    • NAID

      130007382833

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2018-06-01
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Collateral flow and white matter disease in patients with internal carotid artery occlusion.2017

    • Author(s)
      Ishikawa M, Sugawara H, Nagai M, Kusaka G Tanaka Y, Naritaka H
    • Journal Title

      European Neurology

      Volume: 77 Issue: 1-2 Pages: 56-65

    • DOI

      10.1159/000453548

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vein Compression (Cockett’s) Syndrome in an Elderly Patient.2017

    • Author(s)
      Sugawara H, Matsuura K, Ishii A, Yamashita T
    • Journal Title

      Journal of General and Family Medicine

      Volume: 18 Issue: 2 Pages: 88-89

    • DOI

      10.1002/jgf2.28

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anaphylactoid purpura associated with streptococcal cellulitis: A case report and literature review.2017

    • Author(s)
      Saito Y, Ookawara S, Uchiyama H, Ishida T, Kakei M, Sugawara H:
    • Journal Title

      Case Reports in Medicine

      Volume: 2017 Pages: 1-6

    • DOI

      10.1155/2017/5960898

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dysosmia and dysgeusia associated with duloxetine2017

    • Author(s)
      Yoshida K, Fukuchi T, Sugawara H
    • Journal Title

      BMJ Case Reports

      Volume: 2017 Pages: 1-3

    • DOI

      10.1136/bcr-2017-222470

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 適切な抗菌薬治療で再置換を回避した術後長期遠隔期発症の胸部下行大動脈人工血管感染症例-管後型大動脈縮窄症治療に使用した人工血管のメチシリン感受性ブドウ球菌感染症―2016

    • Author(s)
      飯島健太,松沢迪子,川村 愛,渡辺珠美,石井 彰,菅原 斉
    • Journal Title

      自治医科大学紀要

      Volume: 38 Pages: 53-58

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] <i>Nocardia</i> Intramuscular Abscess in an Elderly Patient2016

    • Author(s)
      Kuroda H, Sugawara H, Ishii A, Funasaki S
    • Journal Title

      Internal Medicine

      Volume: 55 Issue: 18 Pages: 2743-2744

    • DOI

      10.2169/internalmedicine.55.7044

    • NAID

      130005414813

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Successful tocilizumab therapy for macrophage activation syndrome associated with adult-onset Still’s disease: a case-based review2016

    • Author(s)
      Watanabe E, Sugawara H, Yamashita T, Ishii1 A, Oda A, Terai C
    • Journal Title

      Case Reports in Medicine

      Volume: Article ID 5656320 Pages: 1-7

    • DOI

      10.1155/2016/5656320

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Regarding the Ambiguity of the Medical Terms &quot;Biologics&quot; and &quot;Biological Agents&quot;2016

    • Author(s)
      Sugawara H
    • Journal Title

      Internal Medicine

      Volume: 55 Issue: 16 Pages: 2327-2327

    • DOI

      10.2169/internalmedicine.55.6841

    • NAID

      130005169370

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Is May and Thurner&apos;s Original Article Appropriate for Characterizing the Iliac Vein Compression Syndrome?2016

    • Author(s)
      Sugawara H, Matsuura K
    • Journal Title

      Internal Medicine

      Volume: 55 Issue: 15 Pages: 2127-2127

    • DOI

      10.2169/internalmedicine.55.7111

    • NAID

      130005254855

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glucose and GTP-binding protein-coupled receptor cooperatively regulate transient receptor potential-channels to stimulate insulin secretion [Review]2016

    • Author(s)
      Kakei M, Yoshida M, Dezaki K, Ito K, Yamada H, Funazaki S, Kawakami M, Sugawara H, and Yada T
    • Journal Title

      Endocrine Journal

      Volume: 63 Issue: 10 Pages: 867-876

    • DOI

      10.1507/endocrj.EJ16-0262

    • NAID

      130005267891

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Aortic Intimal Sarcoma Contributes to Atherosclerotic Renovascular Hypertension: An Autopsy Case Report and Review of the Literature2016

    • Author(s)
      Ishii A, Sugawara H, Nokubi M, Taniguchi Y, Matsuzawa M, Watanabe T, Okochi T, Kakei M, Fujimoto YW, Momomura S
    • Journal Title

      Internal Medicine

      Volume: 55 Issue: 7 Pages: 755-764

    • DOI

      10.2169/internalmedicine.55.5073

    • NAID

      130005141952

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 総合診療科がコーディネートした医療チーム連携の集学的治療によって救命と救肢ができた糖尿病患者のStreptococcal Toxic Shock‐like Syndrome2015

    • Author(s)
      青木 厚,菅原 斉,石井 彰,渡辺珠美,出光俊郎,税田和夫,讃井将満,加計正文,石川三衛,川上正舒
    • Journal Title

      自治医科大学紀要

      Volume: 37 Pages: 35-42

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 記銘力低下を伴う高齢者に発症した街並失認の1例2015

    • Author(s)
      眞山英徳, 崎山快夫, 平松綾子, 石井 彰, 菅原 斉
    • Journal Title

      自治医科大学紀要

      Volume: 37 Pages: 43-46

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 症例を俯瞰する総合診療医の眼.10日間の経過で下腿浮腫と体重増加が進行した32歳男性2015

    • Author(s)
      高山千幸,石井 彰,菅原 斉
    • Journal Title

      診断と治療

      Volume: 103 Pages: 970-973

    • Related Report
      2015 Research-status Report
  • [Journal Article] 1週間以上発熱、咽頭痛が続く41歳女性2015

    • Author(s)
      渡辺珠美,石井 彰,菅原 斉
    • Journal Title

      診断と治療

      Volume: 103 Pages: 1652-1655

    • Related Report
      2015 Research-status Report
  • [Journal Article] Candidemia from an Upper Urinary Tract Infection Complicated by Candida Endophthalmitis2015

    • Author(s)
      Suzuki R, Kuroda H, Matsubayashi H, Ishii A, Toyoda F, Lefor AK, Sugawara H
    • Journal Title

      Internal Medicine

      Volume: 54 Issue: 20 Pages: 2693-2698

    • DOI

      10.2169/internalmedicine.54.4691

    • NAID

      130005103211

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] <i>Coxsackie A16</i> Virus-associated Atypical Hand-foot-and-mouth Disease2014

    • Author(s)
      Matsuzawa M, Ishii A, Demitsu T, Sugawara H
    • Journal Title

      Internal Medicine

      Volume: 53 Issue: 6 Pages: 643-644

    • DOI

      10.2169/internalmedicine.53.1835

    • NAID

      130003392723

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Parsonage-Turner syndrome initially suspected of being orthopedic diseases in a primary care setting: A case report.2014

    • Author(s)
      Yabe H, Kimura M, Ishii A, Sakane H, Iwamoto K, Watanabe T, Sugawara H
    • Journal Title

      Journal of Medical Cases

      Volume: 5 Pages: 197-201

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 生化学検査の考え方③LDHの解釈(重要疾患の入り口)LDH 9,600!えっ,なにこれ?2014

    • Author(s)
      石井 彰,菅原 斉
    • Journal Title

      レジジデントノート

      Volume: 16 Pages: 1098-1104

    • Related Report
      2014 Research-status Report
  • [Journal Article] Involvement of cAMP-EPAC-TRPM2 activation in glucose- and incretin-induced insulin secretion2014

    • Author(s)
      Yoshida M, Dezaki K, Uchida K, Kodera S, Lam NV, Ito K, Rita RS, Yamada H, Shimomura K, Ishikawa SE, Sugawara H, Kawakami M, Tominaga M, Yada T, Kakei M
    • Journal Title

      Diabetes

      Volume: (Epub ahead of print) Issue: 10 Pages: 3394-3403

    • DOI

      10.2337/db13-1868

    • NAID

      40020531124

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] シリーズ:患者の言葉・身体所見を読み解く「帯状疱疹罹患後から持続した倦怠感」.2014

    • Author(s)
      松林洋志,菅原 斉
    • Journal Title

      日本内科学会雑誌

      Volume: 103 Pages: 2835-2840

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 臨床検査データベースの二次利用による極端外れ高値と72時間転帰に関する研究2020

    • Author(s)
      菅原 斉, 斉藤 開, 渡辺 珠美, 中村香代子, 石井 彰, 福地 貴彦
    • Organizer
      第57回埼玉県医学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Creation of a novel 72-hour outcome prognosis prediction model for patients with high critical levels of aspartic aminotransferase: Cross-sectional study, Case-control design.2019

    • Author(s)
      Kai Saito, Takahiko Fukuchi, Tamami Watanabe, Hitoshi Sugawara
    • Organizer
      Japan Chapter, American College of Physicians
    • Related Report
      2019 Annual Research Report
  • [Presentation] C反応性タンパク(CRP)が基準値を大きく外れた極端高値を呈した患者の短期的転帰に関する患者対照研究型横断的研究.2019

    • Author(s)
      斉藤 開,福地貴彦,渡辺珠美,菅原 斉
    • Organizer
      第116回日本内科学会講演会,医学生・研修医の日本内科学会ことはじめ2019名古屋
    • Related Report
      2019 Annual Research Report
  • [Presentation] 基準値を大きく外れた極端な血糖高値を呈した患者の短期的予後とリスク因子に関するケース・コントロール研究2019

    • Author(s)
      渡辺珠美、菅原 斉
    • Organizer
      第17回自治医科大学シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] C反応性タンパク(CRP)が基準値を大きく外れた極端高値を呈した患者の短期的転帰に関する患者対照研究型横断的研究2019

    • Author(s)
      斉藤 開,福地貴彦,渡辺珠美,菅原 斉
    • Organizer
      第116回日本内科学会講演会(医学生・研修医の日本内科学会ことはじめ2019名古屋)
    • Related Report
      2018 Research-status Report
  • [Presentation] D-dimerが基準値を大きく外れた極端な高値を呈した患者の短期的転帰に関するケース・コントロール研究2018

    • Author(s)
      中村香代子,菅原 斉
    • Organizer
      第115回日本内科学会総会
    • Related Report
      2018 Research-status Report 2017 Research-status Report
  • [Presentation] 基準値を大きく外れた極端な血糖高値を呈した患者の短期的予後とリスク因子に関するケース・コントロール研究2018

    • Author(s)
      渡辺珠美、菅原 斉
    • Organizer
      第17回自治医科大学シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] 当医療センター医師臨床研修マッチング成否要因分析ー2016年医師臨床研修マッチング成否との比較ー2018

    • Author(s)
      菅原 斉,大河原晋,桑田知之,市橋 光,讃井將満,遠山信幸,力山敏樹,小山信一郎,百村伸一
    • Organizer
      第55回埼玉県医学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 剖検で確定診断できた食道原発大細胞神経内分泌癌の1例2018

    • Author(s)
      中村香代子,望月美岐,吉田克之,安達迪子,川村 愛,福地貴彦,菅原 斉,仲矢丈雄, 田中 亨,鈴木貴之
    • Organizer
      第636回日本内科学会関東地方会
    • Related Report
      2017 Research-status Report
  • [Presentation] 下腹部痛と水様便を主訴に来院し、腹水セルブロックの免疫染色パネルで腹膜癌と考えられた1例2017

    • Author(s)
      織田恭子、山下武志、渡辺珠美、石井 彰、菅原 斉、春名佑美、近澤研郎、今野 良、野首光弘、田中 亨
    • Organizer
      第54回埼玉県医学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 高齢発症の抗内因子抗体陽性ビタミンB12欠乏症性神経障害をビタミンB12経口薬で治療し得た2例2017

    • Author(s)
      山下武志,吉田克之,川村愛,安達迪子,渡辺珠美,石井 彰,福地貴彦,菅原斉
    • Organizer
      第114回日本内科学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 第2期梅毒に髄膜炎を合併したと考えられる1例2017

    • Author(s)
      湊さおり,山下武志,渡辺珠美,吉田克之,川村 愛,石井 彰,福地貴彦,菅原 斉
    • Organizer
      第114回日本内科学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] インフルエンザA(FluA)がフォークト・小柳・原田病(VKH)の発症契機と考えられた1例2017

    • Author(s)
      吉野 望,川村 愛,石井 彰,吉田克之,山下武志、渡辺珠美,福地貴彦,菅原 斉,豊田文彦,梯 彰弘
    • Organizer
      第114回日本内科学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 出産を契機に急性増悪した妊娠合併肺癌に対してgefinitibが奏功した1例2017

    • Author(s)
      渡辺珠美,山下武志,吉田克之,川村愛,石井 彰,福地貴彦,長井良昭,小山信一郎,堀内 功,高木健次郎,岡島美朗,山田茂樹、田中 亨、菅原 斉
    • Organizer
      第8回日本プライマリ・ケア連合学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Dysosmia and dysgeusia associated with duloxetine.2017

    • Author(s)
      Katsuyuki Yoshida, Takahiko Fukuchi, Hitoshi Sugawara
    • Organizer
      The 8th Annual Conference of Japan Primary Care Association
    • Related Report
      2017 Research-status Report
  • [Presentation] A case of paraneoplastic pemphigus associated with follicular lymphoma.2017

    • Author(s)
      Ai Kamamura, Akira Ishii, Ryunosuke Shioya, Hitoshi Sugawara, Naonori Harada, Mitsuhiko Nokubi, Naoka Umemoto
    • Organizer
      The 8th Annual Conference of Japan Primary Care Association
    • Related Report
      2017 Research-status Report
  • [Presentation] プロトンポンプ阻害薬(PPI)内服とチーズ・スモークサーモン頻回摂食が原因と考えられたリステリア感染症の高齢男性例2017

    • Author(s)
      吉原花子,山下武志,渡辺珠美,中村晃久,野口友里,吉田泰徳,福地貴彦,石井 彰,菅原 斉
    • Organizer
      第634回日本内科学会関東地方会
    • Related Report
      2017 Research-status Report
  • [Presentation] 4か月の短期間で弱視聾となり嚥下障害のため胃瘻造設に至った2型糖尿病合併Cogan症候群の1例2017

    • Author(s)
      中村晃久,山下武志,渡辺珠美,吉原花子,菅原 斉,豊田文彦, 梯 彰弘,田中 享
    • Organizer
      第634回日本内科学会関東地方会
    • Related Report
      2017 Research-status Report
  • [Presentation] 発熱、呼吸不全、意識障害、腎機能障害を呈し、治療抵抗性であった67歳男性2017

    • Author(s)
      渡邉萠理,菅原 斉,田中 亨,寺井千尋
    • Organizer
      日本内科学会関東支部教育セミナー第2回CPC
    • Related Report
      2017 Research-status Report
  • [Presentation] 古典的不明熱の精査で判明したHaemophilus parainfluenzae菌血症の1例2017

    • Author(s)
      望月美岐、鈴木貴之、福地貴彦、菅原 斉
    • Organizer
      第87回日本感染症学会西日本地方会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 化膿性脊椎炎と感染性心内膜炎に対する セフトリアキソン(CTRX)長期間治療が 原因となったと考えられる 急性胆嚢・胆管炎の一例2017

    • Author(s)
      吉原花子,山下武志,中村晃久,野口友里,藤原純一,山中健一,眞嶋浩聡,石井彰,福地貴彦,菅原斉
    • Organizer
      第636回日本内科学会関東地方会
    • Related Report
      2017 Research-status Report
  • [Presentation] 黄疸、大球性貧血、血小板減少が バセドウ病加療のみで改善した一例2017

    • Author(s)
      野口 友里,山下 武志,川村 愛,中村香代子,吉原 花子,福地 貴彦,石井 彰,菅原 斉
    • Organizer
      第636回日本内科学会関東地方会
    • Related Report
      2017 Research-status Report
  • [Presentation] Strategy against MSSA in our Hospital2017

    • Author(s)
      Akihisa Nakamura, Takahiko Fukuchi, Hitoshi Sugawara
    • Organizer
      30th International Congress of Chemotherapy and Infection 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] A case of using ampicillin plus ceftriaxone for infective endocarditis caused by Enterococcus faecalis.2017

    • Author(s)
      Hanako Yoshihara, Takahiko Fukuchi, Hitoshi Sugawara
    • Organizer
      30th International Congress of Chemotherapy and Infection 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Primary intracranial Diffuse Large B-cell Lymphoma in acquired immune deficiency syndrome with previously treated cryptococcal meningitis2017

    • Author(s)
      Yukiko Misaki, Katsuyuki Yoshida, Takahiko Fukuchi, Ryunosuke Shioya, Chiaki Kodama, Miho Yokota, Hitoshi Sugawara
    • Organizer
      30th International Congress of Chemotherapy and Infection 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 基準値を大きく外れた極端な血糖高値を呈した 患者の短期的転帰とそのリスク要因に関する ケース・コントロール研究2017

    • Author(s)
      渡辺珠美,菅原 斉,上羽洋人,尾本きよか
    • Organizer
      第64回日本臨床検査医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 医師臨床研修マッチング成否の要因分析ー当医療センター2016年面接試験結果解析ー2017

    • Author(s)
      菅原 斉,大河原晋,百村伸一
    • Organizer
      第6回日本プライマリ・ケア連合学会関東甲信越ブロック地方会
    • Related Report
      2017 Research-status Report
  • [Presentation] 副鼻腔炎から細菌性髄膜炎を発症し,左外転神経麻痺を生じた一例2017

    • Author(s)
      山下武志,吉田克之,川村 愛,渡辺珠美,石井 彰,福地貴彦,菅原 斉
    • Organizer
      第6回日本プライマリ・ケア連合学会関東甲信越ブロック地方会
    • Related Report
      2017 Research-status Report
  • [Presentation] 肺Mycobacteriumu avium complex症の治療中に播種性脊椎炎を来した一例2017

    • Author(s)
      川村 愛,山下武志,吉原花子,吉田克之,中村香代子,中村晃久,渡辺珠美,石井 彰,福地貴彦,菅原 斉,田中 亨
    • Organizer
      第6回日本プライマリ・ケア連合学会関東甲信越ブロック地方会
    • Related Report
      2017 Research-status Report
  • [Presentation] 短期間で多彩な症状が異時性に出現したサルコイドーシスの一例2016

    • Author(s)
      木村恭彰,吉田克之,福地貴彦,石井彰,浅野岳晴,秋山達,蛭田昌宏,野首光弘,田中亨,菅原斉
    • Organizer
      第62 回日本内科学会関東地方会
    • Place of Presentation
      沖縄
    • Year and Date
      2016-12-10
    • Related Report
      2016 Research-status Report
  • [Presentation] Inoculum effectを実感した多発膿瘍を伴うKlebsiella pneumoniae感染症の一例2016

    • Author(s)
      栗原維吹,吉田克之,福地貴彦,菅原斉
    • Organizer
      第86回日本感染症学会西日本地方会学術集会
    • Place of Presentation
      沖縄
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 当院における感染性心内膜炎2例を含むG群溶連菌菌血症の解析2016

    • Author(s)
      吉田克之,福地貴彦,菅原斉
    • Organizer
      第86回日本感染症学会西日本地方会学術集会
    • Place of Presentation
      沖縄
    • Year and Date
      2016-11-24
    • Related Report
      2016 Research-status Report
  • [Presentation] 摂食障害により心肺停止をきたした警鐘的症例2016

    • Author(s)
      瀬戸那由太,小林千夏,山下武志,渡辺珠美,吉田克之,川村 愛,石井 彰,福地貴彦,岡島美朗,菅原 斉
    • Organizer
      第627回日本内科学会関東地方会
    • Place of Presentation
      東京
    • Year and Date
      2016-10-08
    • Related Report
      2016 Research-status Report
  • [Presentation] 急性漿膜炎で発症した全身性エリテマトーデス(SLE)の一例2016

    • Author(s)
      塩谷竜之介,川村 愛,森野諄記,石井 彰,菅原 斉,杉谷直大,渡辺晋二,渡邉萠理,寺井千尋,飯塚悠祐
    • Organizer
      第627回日本内科学会関東地方会
    • Place of Presentation
      東京
    • Year and Date
      2016-10-08
    • Related Report
      2016 Research-status Report
  • [Presentation] Both low serum ferritin level and high erythrocyte sedimentation rate were significant in the positive for random skin biopsy in patients with clinically suspected intravascular large B-cell lymphoma: a case-control study2016

    • Author(s)
      Katsuyuki Yoshida, Hitoshi Sugawara, Satoshi Nakamura, Mitsuhiro Nokubi, Takeshi Yamashita, Akira Ishii, Ai Kawamura, Naoka Umemoto, Toshio Demitsu, Shigeki Yamada, Akira Tanaka
    • Organizer
      ACP Japan 2016
    • Place of Presentation
      Kyoto
    • Year and Date
      2016-06-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 急性肺炎による呼吸不全が筋緊張性ジストロフィーの診断契機となった2例2016

    • Author(s)
      山下武志,菅原斉,吉田克之,松沢迪子,渡辺珠美,石井彰,加計正文
    • Organizer
      第113回日本内科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2016-04-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 保存的に治療できたアルコール性神経障害によると考えられる偽性腸閉塞症の一例2016

    • Author(s)
      松本圭太,山下武志,成田昌隆,菅原斉,松沢迪子,石井彰,加計正文
    • Organizer
      医学生・研修医の日本内科学会ことはじめ2016東京
    • Place of Presentation
      東京
    • Year and Date
      2016-04-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 異時性に心筋梗塞、脳塞栓、急性門脈・上腸間膜静脈血栓症を順次併発した睡眠時無呼吸症候群の1例2016

    • Author(s)
      菊地望、石井洋輝、松沢迪子、池田奈保子、眞山英徳、山下武志、石井彰、菅原斉
    • Organizer
      第622回日本内科学会関東地方会
    • Place of Presentation
      東京
    • Year and Date
      2016-03-12
    • Related Report
      2015 Research-status Report
  • [Presentation] 腰椎圧迫骨折を契機に診断し得たKlinefelter症候群の一例2015

    • Author(s)
      山下武志、菅原斉、松沢迪子、石井彰、石川三衛、加計正文
    • Organizer
      第618回日本内科学会関東地方会
    • Place of Presentation
      東京
    • Year and Date
      2015-10-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 大動脈縮窄症の大動脈弓部置換術後27年目に発症した人工血管MSSA感染症に対し、抗菌薬による保存的治療で軽快した一例2015

    • Author(s)
      飯島健太, 松沢迪子, 川村 愛, 渡辺珠美, 石井 彰, 菅原 斉
    • Organizer
      第112回日本内科学会総会
    • Place of Presentation
      京都
    • Year and Date
      2015-04-11
    • Related Report
      2015 Research-status Report
  • [Presentation] 関節リウマチ加療中に生じたリステリア敗血症の1例.2014

    • Author(s)
      井上公太,川村 愛,渡辺珠美,石井 彰,松林洋志,松沢迪子,山下武志,菅原 斉,加計正文,百村伸一
    • Organizer
      第611回日本内科学会関東地方会
    • Place of Presentation
      東京
    • Year and Date
      2014-12-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 肺炎、意識障害を契機に判明したACTH単独欠損症の1例.2014

    • Author(s)
      永井康平,小林瑠美子,小糸雄大,江藤宏幸,山下武志,黒田 仁,菅原 斉,生駒亜希,草鹿育代,石川三衛
    • Organizer
      第605回日本内科学会関東地方会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-10
    • Related Report
      2014 Research-status Report
  • [Presentation] 脾静脈-腎静脈シャントによる門脈体循環シャントから高アンモニア血症をきたし意識障害を呈した1例.2014

    • Author(s)
      川村 愛,伊藤みゆき,山下武志,眞山英徳,松林洋志,石井 彰,黒田 仁,菅原 斉,小野澤 裕昌 ,丹野啓介
    • Organizer
      第605回日本内科学会関東地方会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-10
    • Related Report
      2014 Research-status Report
  • [Presentation] 結核暴露の10年後に結核性心膜炎から収縮性心膜炎に至り心膜剥離術で治癒した一例.2014

    • Author(s)
      鈴木怜奈,高山千幸,黒田 仁,菅原 斉,山田容子,片山卓志,田島 泰,安達秀雄,野首光弘,百村伸一
    • Organizer
      第111回日本内科学会総会・講演会サテライトシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2014-04-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 頸部マッサージを契機に血管原性塞栓を起こしたと考えられる脳梗塞の2例.2014

    • Author(s)
      河野妙子,松浦未紗,松林洋志,松沢迪子,黒田 仁,石井 彰,大河内知久,崎山快夫,菅原 斉,加計正文
    • Organizer
      第111回日本内科学会総会・講演会サテライトシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2014-04-12
    • Related Report
      2014 Research-status Report
  • [Presentation] イオパミドール(IPD)蕁麻疹の既往があるにも関わらず,造影CT検査時に偶然投与されたIPDによると考えられる一過性血小板減少をきたした一例.2014

    • Author(s)
      吉田克之,松林洋志,山下武志,渡邉萌理,石井 彰,黒田 仁,渡辺珠美,出光俊郎,江藤宏之,菅原 斉
    • Organizer
      第111回日本内科学会総会・講演会サテライトシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2014-04-12
    • Related Report
      2014 Research-status Report
  • [Remarks] 自治医科大学附属さいたま医療センター総合診療科研究実績

    • URL

      https://www.jichi.ac.jp/center/sinryoka/n_sougou/kensyu.html#jisseki

    • Related Report
      2019 Annual Research Report
  • [Remarks] ORCID

    • URL

      https://orcid.org/my-orcid

    • Related Report
      2019 Annual Research Report
  • [Remarks] Google Scholar

    • URL

      https://scholar.google.co.jp/citations?hl=ja&user=KYynPWIAAAAJ&view_op=list_works&sortby=pubdate

    • Related Report
      2019 Annual Research Report
  • [Remarks] Academia. edu

    • URL

      https://jichi.academia.edu/HItoshiSugawara

    • Related Report
      2019 Annual Research Report
  • [Remarks] Researchmap

    • URL

      https://researchmap.jp/ksmiike1404/

    • Related Report
      2019 Annual Research Report
  • [Remarks] ORCID Hitoshi Sugawara

    • URL

      https://orcid.org/0000-0002-5060-9020

    • Related Report
      2017 Research-status Report
  • [Remarks] 自治医科大学 教員業績データベース

    • URL

      http://kyouingyousekidb.jichi.ac.jp/profile/ja.988c807a4adaef0d.html

    • Related Report
      2017 Research-status Report
  • [Remarks] 自治医科大学附属さいたま医療センター総合診療科

    • URL

      http://www.jichi.ac.jp/center/sinryoka/n_sougou/index.html

    • Related Report
      2016 Research-status Report
  • [Remarks] Academia.edu

    • URL

      https://jichi.academia.edu/HItoshiSugawara

    • Related Report
      2016 Research-status Report
  • [Remarks] researchmap

    • URL

      http://researchmap.jp/ksmiike1404/

    • Related Report
      2016 Research-status Report
  • [Remarks] PUB FACTS

    • URL

      https://www.pubfacts.com/author/Hitoshi+Sugawara?tr=1&tr=2

    • Related Report
      2016 Research-status Report
  • [Remarks] ORCID

    • URL

      http://orcid.org/0000-0002-5060-9020

    • Related Report
      2016 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2021-02-19  

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