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Clarification the pathophysiology of functional dyspepsia

Research Project

Project/Area Number 26460950
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionJuntendo University

Principal Investigator

Nagahara Akihito  順天堂大学, 医学部, 教授 (00266040)

Co-Investigator(Kenkyū-buntansha) 浅岡 大介  順天堂大学, 医学部, 准教授 (30420847)
北條 麻理子  順天堂大学, 医学部, 准教授 (60372934)
Research Collaborator IZUMI Kentaro  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords機能性ディスペプシア / 胃内圧 / 酸分泌抑制薬 / 抗うつ薬 / 抗不安薬 / 多剤併用療法 / 内視鏡 / 消化管運動改善薬 / 消化管運動調節薬 / 抗鬱薬 / マノメトリー
Outline of Final Research Achievements

Functional dyspepsia (FD) is defined as the presence of dyspeptic symptoms in the absence of an organic cause that readily explains them. Although FD is a common disease, mechanisms by which generate symptoms has not been fully understood. We revealed that fasting intragastric pressure may affect the sensation of satiation by high resolution manometry study. Regarding diagnosis, we revealed that minor findings such as erythema, erosion or edema in upper GI endoscopy did not correlate with symptom, in other words, these findings were not necessary to recognize as organic cause. Regarding treatment, we evaluated the efficacy of newly developed anti-acid drug and proved its potent effect and we also showed the effectiveness of antianxiety or antidepressive agents in alleviating FD symptoms. However, efficacy of multidrug therapy was limited in our pilot study. These studies should contribute to construct the evidences to develop adequate therapeutic strategy.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (16 results)

All 2017 2016 2015 2014

All Journal Article (5 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (10 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] Efficacy of a potassium-competitive acid blocker for improving symptoms in patients with reflux esophagitis, non-erosive reflux disease, and functional dyspepsia.2017

    • Author(s)
      Asaoka D, Nagahara A, Hojo M, Matsumoto K, Ueyama H, Matsumoto K, Izumi K, Takeda T, Komori H, Akazawa Y, Shimada Y, Osada T, Watanabe S
    • Journal Title

      Biomedical Report

      Volume: 6 Issue: 2 Pages: 175-180

    • DOI

      10.3892/br.2016.828

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Systematic Review of the Effectiveness of Antianxiety and Antidepressive Agents for Functional Dyspepsia2017

    • Author(s)
      Hojo M, Nagahara A, Asaoka D, Shimada Y, Sasaki H, Matsumoto K, Takeda T, Ueyama H, MatsumotoK, Watanabe S
    • Journal Title

      Internal Medicine

      Volume: 印刷中

    • NAID

      130006235481

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A randomized, double-blind, pilot study of the effect of famotidine on acotiamide treatment for functional dyspepsia2017

    • Author(s)
      Hojo M, Nagahara A, Asaoka D, Takeda T, Izumi K, Matsumoto K, Ueyama H, Shimada Y, Matsumoto K, Nojiri S, Watanabe S
    • Journal Title

      Digestion

      Volume: 投稿中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 機能性ディスペプシアの症状に基づく亜分類は診療に有用か?2015

    • Author(s)
      永原章仁
    • Journal Title

      医学のあゆみ

      Volume: 252 Pages: 734-738

    • Related Report
      2014 Research-status Report
  • [Journal Article] 腸と健康 慢性胃炎・胃癌とH.pylori2014

    • Author(s)
      永原章仁
    • Journal Title

      順天堂醫事雑誌

      Volume: 60 Pages: 8-15

    • Related Report
      2014 Research-status Report
  • [Presentation] 内視鏡的胃炎はFD症状をもたらすか?2017

    • Author(s)
      嶋田裕慈、佐藤俊輔、永原章仁
    • Organizer
      第103回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2017-04-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] 機能性ディスペプシア診療の現状2017

    • Author(s)
      北條麻理子、永原章仁、渡辺純夫
    • Organizer
      第103回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2017-04-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] Intragastric pressure during food intake: the explanatory study in Japanese population using high resolution manonetory2017

    • Author(s)
      Izumi K, Nagahara A, Matsumoto K, Ueyama H, Matsumoto K, Takeda T, Shimada Y, Asaoka D, Watanabe S
    • Organizer
      The 10th International gastrointestinal consensus symposium
    • Place of Presentation
      Nagoya
    • Year and Date
      2017-02-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 改訂Fスケールを指標とした内視鏡所見と症状との関連2016

    • Author(s)
      北條麻里子、永原章仁、渡辺純夫
    • Organizer
      第92回日本消化器内視鏡学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 当院での上部消化管内視鏡検査受検者の上腹部症状 年齢層別解析2016

    • Author(s)
      北條麻里子、永原章仁、渡辺純夫
    • Organizer
      第102回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 抗不安薬・抗うつ薬による機能性ディスペプシアの治療 システマティックレビュー2016

    • Author(s)
      北條麻理子、永原章仁、浅岡大介、嶋田裕慈、松本健史、上山浩也、竹田努、松本紘平、赤澤陽一、泉健太郎、渡辺純夫
    • Organizer
      第12 回日本消化管学会総会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-02-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 上腹部消化器症状を有する患者に対するアコチアミドの治療効果およびファモチジンとの併用効果の検討2015

    • Author(s)
      北條麻理子、永原章仁、浅岡大介、嶋田裕慈、松本健史、上山浩也、竹田努、松本紘平、赤澤陽一、泉健太郎、渡辺純夫
    • Organizer
      第17回日本神経消化器病学会・第9回機能性ディスペプシア研究会・第83回消化器心身医学研究会・第5回IBS研究会 合同学術集会2015
    • Place of Presentation
      沖縄
    • Year and Date
      2015-11-12
    • Related Report
      2015 Research-status Report
  • [Presentation] 機能性ディスペプシア患者に対するカリウムイオン競合型アシッドブロッカー(PCAB)投与の症状改善効果の検討2015

    • Author(s)
      浅岡大介、永原章仁、北條麻理子、嶋田裕慈、松本健史、上山浩也、竹田努、松本紘平、赤澤陽一、泉健太郎、長田太郎、渡辺純夫
    • Organizer
      第17回日本神経消化器病学会・第9回機能性ディスペプシア研究会・第83回消化器心身医学研究会・第5回IBS研究会 合同学術集会2015
    • Place of Presentation
      沖縄
    • Year and Date
      2015-11-12
    • Related Report
      2015 Research-status Report
  • [Presentation] 改訂GERDガイドラインから考える機能性消化管障害の複合 -酸関連上腹部症状と酸非関連上腹部症状- 酸関連上腹部症状の特徴・診断・治療は?2015

    • Author(s)
      永原章仁、浅岡大介、嶋田裕慈、佐々木仁、松本健史、長田太郎、北條麻理子、三輪洋人、草野元康、渡辺純夫
    • Organizer
      第17回日本神経消化器病学会 スポンサードシンポジウム
    • Place of Presentation
      沖縄
    • Year and Date
      2015-11-12
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 主訴別にみた上腹部症状に対するアコチアミドの効果2015

    • Author(s)
      永原章仁
    • Organizer
      第11回日本消化管学会総会学術集会
    • Place of Presentation
      東京 京王プラザホテル
    • Year and Date
      2015-02-13 – 2015-02-14
    • Related Report
      2014 Research-status Report
  • [Book] ガイドライン外来診療20152015

    • Author(s)
      永原章仁
    • Total Pages
      694
    • Publisher
      日経メディカル開発
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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