An analysis of the mechanisms through which bacteria-derived bioactive molecules protect the intestine in enteritis models and primary cultured cells

• Project/Area Number: 26460956
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Asahikawa Medical College
• Principal Investigator: Fujiya Mikihiro 旭川医科大学, 医学部, 准教授 (80322915)
• Co-Investigator(Kenkyū-buntansha): 上野 伸展 旭川医科大学, 医学部, 特任講師 (30436000) ; 稲場 勇平 旭川医科大学, 大学病院, その他 (30447099) ; 盛一 健太郎 旭川医科大学, 医学部, 講師 (70455715)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: 腸内細菌 / プロバイオティクス / 炎症性腸疾患 / 消化器癌 / ポリリン酸 / 腸炎 / 大腸癌

Outline of Final Research Achievements

We previously proposed that probiotic-derived CSF and polyphosphate have protective effects in the intestine. This study investigated the functional mechanisms of these molecules. CSF was transported by OCTN2 and decreased the expression of inflammation-related cytokines, including IL-6, 7 and CXCL-1. Polyphosphate formed a complex with integrin b1 and caveolin-1 which was taken by endocytosis. It then activated p38 MAPK and augmented the intestinal barrier function, leading to the improvement of intestinal injury in a mouse model of enteritis. These results provide the detailed mechanisms of how probiotic-derived molecules protect the intestine and may contribute to the development of new drugs after the completion of preclinical and clinical studies.

Research Products

• [Int'l Joint Research] シカゴ大学(米国)
• [Journal Article] An elevated expression of serum exosomal microRNA-191, -21, -451a of pancreatic neoplasm is considered to be efficient diagnostic marker (2018)
  • Author(s): Goto Takuma、Fujiya Mikihiro、Konishi Hiroaki、Sasajima Junpei、Fujibayashi Shugo、Hayashi Akihiro、Utsumi Tatsuya、Sato Hiroki、Iwama Takuya、Ijiri Masami、Sakatani Aki、Tanaka Kazuyuki、Nomura Yoshiki、Ueno Nobuhiro、Kashima Shin、Moriichi Kentaro、Mizukami Yusuke、Kohgo Yutaka、Okumura Toshikatsu
  • Journal Title: BMC Cancer Volume: 18 Issue: 1 Pages: 1-11
  • DOI: 10.1186/s12885-018-4006-5
  • Peer Reviewed / Open Access
• [Journal Article] Echinococcosis infection diagnosed based on the histological findings of a lymph node involvement obtained by endoscopic ultrasound-guided fine-needle aspiration. (2018)
  • Author(s): Moriichi K, Fujiya M, Goto T, Okumura T.
  • Journal Title: Endoscopic ultrasound Volume: in press Issue: 3 Pages: 210-210
  • DOI: 10.4103/eus.eus_90_17
  • Peer Reviewed
• [Journal Article] Detection and characterization of colitis-associated cancer/dysplasia: Based on reports from the JDDW2017 and meta-analyses of prospective studies concerning endoscopic procedure (2018)
  • Author(s): Fujiya M.
  • Journal Title: Digestive Endoscopy Volume: in press Issue: 3 Pages: 332-337
  • DOI: 10.1111/den.13024
  • Peer Reviewed
• [Journal Article] A Case of Alpha-Fetoprotein-Producing Adenocarcinoma of the Esophagogastric Junction in which Long-Term Survival Was Achieved by Means of Individualized Multidisciplinary Therapy (2018)
  • Author(s): Tanaka Kazuyuki、Fujiya Mikihiro、Ijiri Masami、Takahashi Keitaro、Ando Katsuyoshi、Nomura Yoshiki、Ueno Nobuhiro、Kashima Shin、Goto Takuma、Sasajima Junpei、Ito Takahiro、Moriichi Kentaro、Mizukami Yusuke、Tanabe Hiroki、Okumura Toshikatsu
  • Journal Title: Journal of Gastrointestinal Cancer Volume: - Issue: 3 Pages: 617-620
  • DOI: 10.1007/s12029-018-0078-3
  • NAID: 120006496820
  • Peer Reviewed
• [Journal Article] Endoscopic Submucosal Dissection for Depressed-type Early Adenocarcinoma of the Terminal Ileum (2017)
  • Author(s): Takahashi K, Ito T, Sato T, Goto M, Kawamoto T, Fujinaga A, Yanagawa N, Saito Y, Sato K, Fujiya M.
  • Journal Title: Internal Medicine Volume: 56 Issue: 10 Pages: 1153-1156
  • DOI: 10.2169/internalmedicine.56.8101
  • NAID: 130006858057
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Inverted gastric adenocarcinoma of fundic gland mucosa type colliding with well-differentiated adenocarcinoma: a case report. (2017)
  • Author(s): Takahashi K, Fujiya M, Ichihara S, Moriichi K, Okumura T.
  • Journal Title: Medicine (Baltimore) Volume: 96 Issue: 23 Pages: e7080-e7080
  • DOI: 10.1097/md.0000000000007080
  • NAID: 120006484350
  • Peer Reviewed / Open Access
• [Journal Article] Ferrichrome identified from Lactobacillus casei ATCC334 induces apoptosis through its iron-binding site in gastric cancer cells (2017)
  • Author(s): Ijiri Masami、Fujiya Mikihiro、Konishi Hiroaki、Tanaka Hiroki、Ueno Nobuhiro、Kashima Shin、Moriichi Kentaro、Sasajima Junpei、Ikuta Katsuya、Okumura Toshikatsu
  • Journal Title: Tumor Biology Volume: 39 Issue: 6 Pages: 101042831771131-101042831771131
  • DOI: 10.1177/1010428317711311
  • NAID: 120006473651
  • Peer Reviewed / Open Access
• [Journal Article] The endoscopic findings of the upper gastrointestinal tract in patients with Crohn's disease. (2017)
  • Author(s): Nomura Y, Moriichi K, Fujiya M, Okumura T.
  • Journal Title: Clin J Gastroenterol Volume: 10 Issue: 4 Pages: 289-296
  • DOI: 10.1007/s12328-017-0759-7
  • Peer Reviewed / Open Access
• [Journal Article] 腸内細菌を標的とした消化器疾患の治療法 (2017)
  • Author(s): 藤谷幹浩
  • Journal Title: INTESTINE Volume: 21 Pages: 341-350
• [Journal Article] Daikenchuto (TU-100) Suppresses Tumor Development in the Azoxymethane and APCmin/+ Mouse Models of Experimental Colon Cancer. (2017)
  • Author(s): Hasebe T, Matsukawa J, Ringus D, Miyoshi J, Hart J, Kaneko A, Yamamoto M, Kono T, Fujiya M, Kohgo Y,Wang C, Yuan C, Bissonnette M, Musch MW, Chang EB.
  • Journal Title: Phytotherapy Research Volume: 31 Issue: 1 Pages: 90-99
  • DOI: 10.1002/ptr.5735
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Kono-S anastomosis for surgical prophylaxis of anastomotic recurrence in Crohn’s disease: an international multicenter study. (2016)
  • Author(s): Kono T, Fichera A, Maeda K, Sakai Y, Ohge H, Krane M, Katsuno H, Fujiya M.
  • Journal Title: J Gastrointest Surg Volume: 20 Issue: 4 Pages: 783-90
  • DOI: 10.1007/s11605-015-3061-3
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Management of colorectal T1 carcinoma treated by endoscopic resection (EAST). (2016)
  • Author(s): Saitoh Y, Inaba Y, Sasaki T, Sugiyama R, Sukegawa R, Fujiya M.
  • Journal Title: Digestive Endoscopy Volume: 28 Issue: 3 Pages: 324-9
  • DOI: 10.1111/den.12503
  • Peer Reviewed
• [Journal Article] A meta-analysis of efficacy and adverse events of cold vs. hot polypectomy. (2016)
  • Author(s): Fujiya M, Sato H, Ueno N, Sakatani A, Tanaka K, Dokoshi T, Fujibayashi S, Nomura Y, Kashima S, Gotoh T, Sasajima J, Moriichi K, Watari J, Kohgo Y.
  • Journal Title: World Journal of Gastroenterology Volume: 21 Issue: 23 Pages: 5436-44
  • DOI: 10.3748/wjg.v22.i23.5436
  • Peer Reviewed / Open Access
• [Journal Article] Infection with fully mature Corynosoma cf. validum causes ulcers in the human small intestine. (2016)
  • Author(s): Takahashi K, Ito T, Sato T, Goto M, Kawamoto T, Fujinaga A, Yanagawa N, Saito Y, Nakao M, Hasegawa H, Fujiya M.
  • Journal Title: Clin J Gastroenterol Volume: 9 Issue: 3 Pages: 114-7
  • DOI: 10.1007/s12328-016-0646-7
  • Peer Reviewed / Open Access
• [Journal Article] The efficacy of autofluorescence imaging in the diagnosis of colorectal diseases. (2016)
  • Author(s): Moriichi K, Fujiya M, Okumura T.
  • Journal Title: Clin J Gastroenterol Volume: 9 Issue: 4 Pages: 175-83
  • DOI: 10.1007/s12328-016-0658-3
  • Peer Reviewed / Open Access
• [Journal Article] Probiotic-derived ferrichrome inhibits colon cancer progression via JNK-mediated apoptosis (2016)
  • Author(s): Hiroaki Konishi, Mikihiro Fujiya, Hiroki Tanaka, Nobuhiro Ueno, Kentaro Moriichi, Junpei Sasajima, Katsuya Ikuta, Hiroaki Akutsu, Hiroki Tanabe, Yutaka Kohgo
  • Journal Title: Nature Communications Volume: 7:12365 Issue: 1 Pages: 12365-12365
  • DOI: 10.1038/ncomms12365
  • NAID: 120006305684
  • Peer Reviewed / Open Access
• [Journal Article] Soluble bioactive microbial mediators regulate proteasomal degradation and autophagy to protect against inflammation-induced stress. (2016)
  • Author(s): Inaba Y, Ueno N, Numata M, Zhu X, Messer JS, Boone DL, Fujiya M, Kohgo Y, Musch MW, Chang EB.
  • Journal Title: Am J Physiol Gastrointest Liver Physiol Volume: 311 Issue: 4 Pages: G634-G647
  • DOI: 10.1152/ajpgi.00092.2016
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 上部消化管内視鏡を用いたクローン病診断における「竹の節状外観」の臨床的意義 (2016)
  • Author(s): 田邊裕貴, 横田欽一, 野村好紀, 安藤勝祥, 坂谷慧, 田中一之, 堂腰達矢, 嘉島伸, 上野伸展, 稲場勇平, 伊藤貴博, 須藤大輔, 太田勝久, 一石英一郎, 佐藤貴一, 大竹孝明, 高後裕, 盛一健太郎, 藤谷幹浩．
  • Journal Title: 日本消化器病学会雑誌 Volume: 113 Pages: 1208-1215
  • NAID: 130005162983
  • Peer Reviewed
• [Journal Article] Lactobacillus brevis-derived polyphosphate inhibits colon cancer progression through the induction of cell apoptosis. (2016)
  • Author(s): Sakatani A, Fujiya M, Ueno N, Kashima S, Sasajima J, Moriichi K, Ikuta K, Tanabe H, Kohgo Y.
  • Journal Title: Anticancer Res Volume: 36 Pages: 591-598
  • Peer Reviewed / Open Access
• [Journal Article] Host-Microbe Interactions via Membrane Transport Systems. (2015)
  • Author(s): Konishi H, Fujiya M, Kohgo Y.
  • Journal Title: Environ Microbiol Volume: 17 Issue: 4 Pages: 931-937
  • DOI: 10.1111/1462-2920.12632
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Heterogeneous nuclear ribonucleoprotein A1 improves the intestinal injury by regulating apoptosis via trefoil factor 2 in mice with anti-CD3-induced enteritis. (2015)
  • Author(s): Ando K, Fujiya M, Konishi H, Ueno N, Inaba Y, Moriichi K, Ikuta K, Tanabe H, Ohtake T, Kohgo Y.
  • Journal Title: Inflammatory Bowel Diseases Volume: 21 Issue: 7 Pages: 1541-1552
  • DOI: 10.1097/mib.0000000000000401
  • Peer Reviewed
• [Journal Article] Polyphosphate, an active molecule derived from probiotic Lactobacillus brevis, improves the fibrosis in murine colitis. (2015)
  • Author(s): Kashima S, Fujiya M, Konishi H, Ueno N, Inaba Y, Moriichi K, Tanabe H, Ikuta K, Ohtake T, Kohgo Y.
  • Journal Title: Transl Res. Volume: in press Issue: 2 Pages: 00069-9
  • DOI: 10.1016/j.trsl.2015.02.002
  • NAID: 120005837997
  • Peer Reviewed / Open Access
• [Journal Article] Probiotic-derived polyphosphate improves the intestinal barrier function through the caveolin-dependent endocytic pathway. (2015)
  • Author(s): Tanaka K, Fujiya M, Konishi H, Ueno N, Sasajima J, Moriichi K, Ikuta K, Tanabe H, Kohgo Y.
  • Journal Title: Biochem Biophys Res Commun Volume: 467 Issue: 3 Pages: 541-548
  • DOI: 10.1016/j.bbrc.2015.09.159
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy and adverse events of EMR and endoscopic submucosal dissection for the treatment of colon neoplasms: a meta-analysis of studies comparing EMR and endoscopic submucosal dissection. (2015)
  • Author(s): Fujiya M, Tanaka K, Dokoshi T, Tominaga M, Ueno N, Inaba Y, Ito T, Moriichi K, Kohgo Y.
  • Journal Title: Gastrointest Endosc. Volume: 81 Issue: 3 Pages: 583-95
  • DOI: 10.1016/j.gie.2014.07.034
  • Peer Reviewed
• [Journal Article] The production of coagulation factor VII by adipocytes is enhanced by tumor necrosis factor-α or isoproterenol (2015)
  • Author(s): N Takahashi, T Yoshizaki, N Hiranaka, O Kumano, T Suzuki, M Akanuma, T Yui, K Kanazawa, M Yoshida, S Naito, M Fujiya, Y Kohgo, M Ieko
  • Journal Title: International Journal of Obesity Volume: 39 Issue: 5 Pages: 747-754
  • DOI: 10.1038/ijo.2014.208
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] TU-100 (Daikenchuto) and Ginger Ameliorate Anti-CD3 Antibody Induced T Cell-Mediated Murine Enteritis: Microbe-Independent Effects Involving Akt and NF-κB Suppression. (2014)
  • Author(s): Ueno N, Hasebe T, Kaneko A, Yamamoto M, Wang Y, Fujiya M, Kohgo Y, Kono T, Musch MW, Chang EB.
  • Journal Title: PloS One Volume: 23 Issue: 5 Pages: e97456-e97456
  • DOI: 10.1371/journal.pone.0097456
  • Peer Reviewed / Open Access
• [Journal Article] Effectiveness of pazopanib for postoperative recurrence of granulocyte colony-stimulating factor-producing primary hepatic angiosarcoma. (2014)
  • Author(s): Sawada K. Soma M, Nakajima S, Hasebe T, Maeda S, Abe M, Ohtake T, Saito Y, Hasebe C, Yamamoto M, Fujiya M, Torimoto Y, Kohgo Y.
  • Journal Title: International Cancer Conference Journal Volume: 4 Issue: 1 Pages: 41-47
  • DOI: 10.1007/s13691-014-0167-5
  • Peer Reviewed
• [Journal Article] microRNA-18a induces apoptosis in colon cancer cells via the autophagolysosomal degradation of oncogenic heterogeneous nuclear ribonucleoprotein A1. (2014)
  • Author(s): Fujiya M, Konishi H, Kamel M.K.M, Ueno N, Inaba Y, Moriichi K, Tanabe H, Ikuta K, Ohtake T, Kohgo Y.
  • Journal Title: Oncogene Volume: in press Issue: 40 Pages: 4847-56
  • DOI: 10.1038/onc.2013.429
  • Peer Reviewed
• [Journal Article] Decreased vessel networks and irregular vessel on narrow band imaging are useful findings to distinguish intestinal lymphoma from lymphoid hyperplasia. (2014)
  • Author(s): Fujiya M, Kashima S, Ikuta K, Dokoshi T, Sakatani A, Tanaka K, Ando K, Ueno N, Tominaga M, Inaba Y, Ito T, Moriichi K, Tanabe H, Saitoh Y, Kohgo Y.
  • Journal Title: Gastrointestinal Endoscopy Volume: in press Issue: 6 Pages: 1064-71
  • DOI: 10.1016/j.gie.2014.03.030
  • Peer Reviewed
• [Presentation] 乳酸菌由来分子を用いた新規炎症性腸疾患治療薬の開発 (2018)
  • Author(s): 藤谷幹浩、上野伸展、嘉島 伸、田中一之、坂谷 慧、垂石正樹、奥村利勝
  • Organizer: 厚生労働科学研究 難治性疾患克服研究事業「難治性炎症性腸管障害に関する調査研究」平成29年度第2 回総会
• [Presentation] Ferrichrome, a tumor suppressive molecule derived from Lactobacillus casei, inhibits the progression of colorectal cancer via the endoplasmic reticulum stress pathway. (2017)
  • Author(s): Konishi H, Fujiya M, Ijiri M, Tanaka K, Fujibayashi S, Goto T, Kashima S, Ando K, Takahashi K, Ueno N, Sasajima J, Moriichi K, Tanaka H, Ikuta K, Okumura T.
  • Organizer: DDW 2017 (AGA)
  • Int'l Joint Research
• [Presentation] 乳酸菌由来分子による腸炎治療 (2017)
  • Author(s): 藤谷幹浩
  • Organizer: 第17回日本抗加齢医学会総会
• [Presentation] 潰瘍性大腸炎における治療の現状・臨床ニーズ (2017)
  • Author(s): 藤谷幹浩
  • Organizer: 技術情報協会セミナー
  • Invited
• [Presentation] 乳酸菌由来分子を用いた新規炎症性腸疾患治療薬の開発 (2017)
  • Author(s): 藤谷幹浩、上野伸展、嘉島 伸、田中一之、坂谷 慧、垂石正樹、奥村利勝．
  • Organizer: 厚生労働科学研究 難治性疾患克服研究事業「難治性炎症性腸管障害に関する調査研究」平成29年度第1回総会
• [Presentation] 長鎖ポリリン酸による潰瘍性大腸炎に対する基礎研究～医師主導治験 (2017)
  • Author(s): 藤谷幹浩
  • Organizer: 生体機能と創薬シンポジウム2017
  • Invited
• [Presentation] プロバイオティクス由来の活性物質ポリン酸を用いた新規炎症性腸疾患治療薬の開発 (2017)
  • Author(s): 藤谷幹浩
  • Organizer: 疾病克服戦略会議 疾病克服戦略会議－潰瘍性大腸炎－
  • Invited
• [Presentation] 乳酸菌由来フェリクロームによる抗腫瘍メカニズムの解析 (2017)
  • Author(s): 井尻学見、藤谷幹浩、上野伸展、奥村利勝
  • Organizer: 第45回日本消化器免疫学会
• [Presentation] プロバイオティクス由来分子を用いた難病・癌治療薬の開発 (2017)
  • Author(s): 藤谷幹浩
  • Organizer: 第60回ヒューマンサイエンス・バイオインターフェース
  • Invited
• [Presentation] シンポジウム1常在細菌叢・粘膜免疫「乳酸菌由来ポリリン酸を用いた新規炎症性腸疾患治療薬の臨床応用へ向けた開発研究開発」 (2016)
  • Author(s): 藤谷幹浩
  • Organizer: 第44回日本臨床免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2016-09-08
  • Invited
• [Presentation] 『内科疾患アップデート～2016年』ミニレクチャー 炎症性腸疾患診療；最近の話題 (2016)
  • Author(s): 藤谷幹浩
  • Organizer: 日本内科学会北海道支部教育セミナー
  • Place of Presentation: 札幌
  • Year and Date: 2016-07-23
  • Invited
• [Presentation] Evaluation of the disease activity in UC by white light and autofluorescence imaging. (2016)
  • Author(s): Ijiri M, Fujiya M, Iwama T, Sakatani A, Ueno N, Okumura T.
  • Organizer: The 4th Annual Meeting of Asian Organization for Crohn’s & Colitis
  • Place of Presentation: Kyoto
  • Year and Date: 2016-07-07
  • Int'l Joint Research
• [Presentation] The pre-operative use of infliximab prevents the shortening of the small intestine in patients with Crohn’s disease. (2016)
  • Author(s): Sakatani A, Fujiya M, Iwama T, Ijiri M, Ueno N, Okumura T.
  • Organizer: The 4th Annual Meeting of Asian Organization for Crohn’s & Colitis
  • Place of Presentation: Kyoto
  • Year and Date: 2016-07-07
  • Int'l Joint Research
• [Presentation] PD.1 Translational medicineへの展開を目指した腸疾患研究「菌由来の活性物質であるポリリン酸を用いた新規炎症性腸疾患治療薬の開発」 (2016)
  • Author(s): 上野伸展、藤谷幹浩．
  • Organizer: 第102回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2016-07-07
• [Presentation] Evaluation of disease activity in patients with UC by white light, magnifying and autofluorescence imaging. (2016)
  • Author(s): Moriichi K, Fujiya M, Iwama T, Sato H, Utsumi T, Ijiri M, Tanaka K, Sakatani A, Fujibayashi S, Nomura Y, Ueno N, Kashima S, Goto T, Sasajima J.
  • Organizer: DDW 2016 (ASGE)
  • Place of Presentation: San Diego
  • Year and Date: 2016-05-21
  • Int'l Joint Research
• [Presentation] Safety, Tolerability and Efficacy of E6011, Anti-Human Fractalkine Monoclonal Antibody, in the First-in-Patient Study for Crohn’s Disease. (2016)
  • Author(s): Matsuoka K, Naganuma M, Matsui T, Arai M, Tanida S, Kitamura K, Horiki N, Fujiya M, Iimuro M, Mitsuyama K, Saruta M, Matsumoto T, Nebiki H, Esaki M, Kinjo F, Oketani K, Hojo S, Akama H, Imai T, Tsubouchi H, Hibi T, Kanai T.
  • Organizer: DDW 2016 (AGA)
  • Place of Presentation: San Diego
  • Year and Date: 2016-05-21
  • Int'l Joint Research
• [Presentation] 菌由来の活性物質であるポリリン酸を用いた新規炎症性腸疾患治療薬の開発 (2016)
  • Author(s): 上野伸展、藤谷幹浩．
  • Organizer: 第102回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2016-04-21
• [Presentation] 腸内細菌由来ポリリン酸を用いた新規炎症性腸疾患治療薬の開発 (2015)
  • Author(s): 藤谷幹浩、高後 裕．
  • Organizer: 第43回日本臨床免疫学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2015-10-22
  • Invited
• [Presentation] 乳酸菌由来長鎖ポリリン酸による腸管免疫の制御 (2015)
  • Author(s): 藤谷幹浩、嘉島 伸、小西弘晃、上野伸展、高後 裕．
  • Organizer: 第52回日本消化器免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2015-07-30
• [Presentation] Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) improves the intestinal injury through upregulating trefoil factor 2 in mice with anti-CD3-induced enteritis. (2015)
  • Author(s): Fujiya M, Kohgo Y.
  • Organizer: GI Research Academy 2015
  • Place of Presentation: Tokyo
  • Year and Date: 2015-06-12
• [Presentation] University-oriented seed（biogenic）collaborated with company supported by Government (2015)
  • Author(s): Fujiya M
  • Organizer: 第101回日本消化器病学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2015-04-23
  • Invited
• [Presentation] Oral dietary administration of heat-killed Lactobacillus brevis SBC8803 alters the gut microbiome and ameliorates experimental colitis in mice. (2014)
  • Author(s): Ueno N, Fujiya M, Konishi H, Sakatani A, Tanaka K, Dokoshi T, Ando K, Kashima S, Inaba Y, Moriichi K, Kohgo Y.
  • Organizer: 2014 Advanced in Inflammatory Bowel Disease
  • Place of Presentation: Orland
  • Year and Date: 2014-12-04
• [Presentation] Host-microbial interaction in BD」A novel host-microbial interaction via the uptake of probiotic-derived molecules by intestinal epithelia. (2014)
  • Author(s): Fujiya M, Ueno N, Kohgo Y.
  • Organizer: JDDW 2014 (第56回日本消化器病学会、第88回日本消化器内視鏡学会、第12回日本消化器外科学会)
  • Place of Presentation: Kobe
  • Year and Date: 2014-10-24
• [Presentation] A probiotic-derived polyphosphate improves the fibrosis in a murine model of chronic colitis via the regulation of inflammation- and fibrosis-associated mediators. (2014)
  • Author(s): Fujiya M, Konishi H, Ueno N, Inaba Y, Moriichi K, Kohgo Y.
  • Organizer: GI Research Academy 2014
  • Place of Presentation: Tokyo
  • Year and Date: 2014-06-06
• [Presentation] Long-term oral dietary administration of a new probiotic, Lactobacillus brevis SBC8803, alters gut the microbiota and ameliorates DSS-induced colitis in mice. (2014)
  • Author(s): Ueno N, Fujiya M, Segawa S, Konishi H, Sakatani A, Tanaka K, Dokoshi T, Ando K, Kashima S, Inaba Y, Ito T, Moriichi K, Shigyo T, Kohgo Y.
  • Organizer: DDW 2014 (AGA)
  • Place of Presentation: Chicago
  • Year and Date: 2014-05-06
• [Presentation] MicroRNA-18a induces apoptosis in colon cancer cells through the autophagosomal degradation of hnRNP A1. (2014)
  • Author(s): Konishi H, Fujiya M, Ando K, Tanaka K, Sakatani A, Dokoshi T, Inaba Y, Fujibayashi S, Goto T, Kashima S, Ueno N, Sasajima J, Ito T, Tanaka H, Ikuta K, Kohgo Y.
  • Organizer: DDW 2014 (AGA)
  • Place of Presentation: Chicago
  • Year and Date: 2014-05-06
• [Book] 消化器研修ノート (2016)
  • Author(s): 藤谷幹浩
  • Total Pages: 708
  • Publisher: 診断と治療社
• [Patent(Industrial Property Rights)] 特許 (2017)
  • Inventor(s): 藤谷幹浩、小西弘晃、盛一健太郎
  • Industrial Property Rights Holder: 国立大学法人旭川医科大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017-01-19
  • Overseas
• [Patent(Industrial Property Rights)] 抗腫瘍剤 (2016)
  • Inventor(s): 藤谷幹浩、小西弘晃、盛一健太郎
  • Industrial Property Rights Holder: 国立大学法人旭川医科大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-009224
  • Filing Date: 2016-01-20
• [Patent(Industrial Property Rights)] 食道アカラシア感受性遺伝子多型 (2015)
  • Inventor(s): 高後裕、藤谷幹浩、田中宏樹
  • Industrial Property Rights Holder: 高後裕、藤谷幹浩、田中宏樹
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-061460
  • Filing Date: 2015-03-24