| Project/Area Number |
26460956
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
上野 伸展 旭川医科大学, 医学部, 特任講師 (30436000)
稲場 勇平 旭川医科大学, 大学病院, その他 (30447099)
盛一 健太郎 旭川医科大学, 医学部, 講師 (70455715)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 腸内細菌 / プロバイオティクス / 炎症性腸疾患 / 消化器癌 / ポリリン酸 / 腸炎 / 大腸癌 |
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| Outline of Final Research Achievements |
We previously proposed that probiotic-derived CSF and polyphosphate have protective effects in the intestine. This study investigated the functional mechanisms of these molecules. CSF was transported by OCTN2 and decreased the expression of inflammation-related cytokines, including IL-6, 7 and CXCL-1. Polyphosphate formed a complex with integrin b1 and caveolin-1 which was taken by endocytosis. It then activated p38 MAPK and augmented the intestinal barrier function, leading to the improvement of intestinal injury in a mouse model of enteritis. These results provide the detailed mechanisms of how probiotic-derived molecules protect the intestine and may contribute to the development of new drugs after the completion of preclinical and clinical studies.
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