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Investigation of the role of mucosal inductive immune system via indigenous bactria and dietary antigens

Research Project

Project/Area Number 26460969
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionOsaka University

Principal Investigator

Iijima Hideki  大阪大学, 医学系研究科, 准教授 (90444520)

Co-Investigator(Kenkyū-buntansha) 辻井 正彦  大阪大学, 医学系研究科, 招へい教授 (40303937)
新崎 信一郎  大阪大学, 医学系研究科, 助教 (60546860)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords炎症性腸疾患 / パイエル板 / 粘膜免疫誘導組織 / 腸内細菌 / 粘膜免疫 / NSAID起因性小腸潰瘍 / ケモカインレセプター / 小腸潰瘍 / インドメタシン / 腸管粘膜障害 / immunonutrition / CCR7 / 小腸パイエル板
Outline of Final Research Achievements

Ulceration of the small intestine is induced when mice were intraperitoneally injected with indomethacine. We found chemokine receptor CCR7-deficient mice show worsening of the ulcer area in the small intestine. In addition, the population of CD103-positive dendritic cells which have a role for the induction of regulatory T cells was decreased in CCR7-deficient mice.
In contrast, ulcer area was significantly decreased in the wild-type mice orally administered nutritional therapy containing RNA and other nutrients (Impact(R)) or elementary diet with amino-acids. In mice treated with Impact showed significantly increased CD103-positive dendritic cells. These results indicate the importance of CD103-positive dendritic cells and immune-nutritional therapy and they can be effective to regulate mucosal immunity-associated intestinal inflammation.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (21 results)

All 2017 2016 2015 2014

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 2 results,  Acknowledgement Compliant: 3 results) Presentation (11 results) (of which Int'l Joint Research: 5 results,  Invited: 1 results)

  • [Journal Article] Leucine-rich Alpha-2 Glycoprotein is a Serum Biomarker of Mucosal Healing in Ulcerative Colitis2017

    • Author(s)
      Shinzaki, S., Matsuoka, K., Iijima, H., Mizuno, S., Serada, S., Fujimoto, M., Arai, N. Koyama, N., Morii, E., Watanabe, M., Hibi, T., Kanai, T., Takehara, T., Naka, T.
    • Journal Title

      Journal of Crohn's and Colitis

      Volume: 11(1) Issue: 1 Pages: 84-91

    • DOI

      10.1093/ecco-jcc/jjw132

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age at onset is associated with the seasonal pattern of onset and exacerbation in inflammatory bowel disease2017

    • Author(s)
      Araki, M, Shinzaki, S., Yamada, T., Arimitsu S., Komori, M., Shibukawa, N., Mukai A., Nakajima, S., Kinoshita, K., Kitamura, S., Murayama, Y., Ogawa H., Yasunaga Y, Oshita, M., Fukui, H., Masuda E., Tsujii, M., Hiyama, S., Inoue, T., Iijima, H., Takehara, T.
    • Journal Title

      Journal of Gastroenterology

      Volume: 印刷中 Issue: 11 Pages: 1149-1157

    • DOI

      10.1007/s00535-017-1313-6

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Indigo Naturalis ameliorates murine dextran sodium sulfate-induced colitis via aryl hydrocarbon receptor activation.2017

    • Author(s)
      Kawai S, Iijima H, Shinzaki S, Hiyama S, Yamaguchi T, Araki M, et al.
    • Journal Title

      J Gastroenterol.

      Volume: 印刷中 Issue: 8 Pages: 904-919

    • DOI

      10.1007/s00535-016-1292-z

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] N-Acetylglucosaminyltransferase V exacerbates murine colitis with macrophage dysfunction and enhances colitic tumorigenesis.2016

    • Author(s)
      Shinzaki S, Ishii M, Fujii H, Iijima H, Wakamatsu K, Kawai S, Shiraishi E, Hiyama S, Inoue T, Hayashi Y, Kuwahara R, Takamatsu S, Kamada Y, Morii E, Tsujii M, Takehara T, Miyoshi E.
    • Journal Title

      J Gastroenterol

      Volume: 51 Issue: 4 Pages: 357-69

    • DOI

      10.1007/s00535-015-1112-x

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] N-Acetylglucosaminyltransferase V exacerbates murine colitis with macrophage dysfunction and enhances colitic tumorigenesis.2016

    • Author(s)
      Shinzaki S, Ishii M, Fujii H, Iijima H, Wakamatsu K, Kawai S, Shiraishi E, Hiyama S, Inoue T, Hayashi Y, Kuwahara R, Takamatsu S, Kamada Y, Morii E, Tsujii M, Takehara T, Miyoshi E.
    • Journal Title

      J Gastroenterol.

      Volume: 51 Issue: 4 Pages: 357-369

    • DOI

      10.1007/s00535-015-1119-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia.2016

    • Author(s)
      Okumura R, Kurakawa T, Nakano T, Kayama H, Kinoshita M, Motoka D, Gotoh K, Kimura T, Kamiyama N, Kusu T, Ueda Y, Wu H, Iijima H, Barman S, Osawwa H, Matsuno H, Nishimura J, Ohba Y, Nakamura S, Iida T, Yamamoto M, Umemoto E, Sano K, and Takeda K
    • Journal Title

      Nature

      Volume: 532 Issue: 7597 Pages: 117-121

    • DOI

      10.1038/nature17406

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Narrow-band imaging with magnifying endoscopy for Peyer's patches is useful in predicting the recurrence of remissive patients with ulcerative colitis.2016

    • Author(s)
      Hiyama S, Iijima H, Kawai S, Mukai A, Shiraishi E, Iwatani S, et al.
    • Journal Title

      Intest Res.

      Volume: 14(4) Issue: 4 Pages: 314-21

    • DOI

      10.5217/ir.2016.14.4.314

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Core Fucosylation on T cells, Required for Activation of T-cell Receptor Signaling and Induction of Colitis in Mice, is Increased in Patients with Inflammatory Bowel Disease.2016

    • Author(s)
      Fujii H, Shinzaki S, Iijima H, Wakamatsu K, Iwamoto C, Sobajima T, Kuwahara R, Hiyama S, Hayashi Y, Takamatsu S, Uozumi N, Kamada Y, Tsujii M, Taniguchi N, Takehara T, Miyoshi E
    • Journal Title

      Gastroenterology

      Volume: 未定 Issue: 7 Pages: 00297-3

    • DOI

      10.1053/j.gastro.2016.03.002

    • NAID

      40021255019

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of aberrant IgG glycosylation in the pathogenesis of inflammatory bowel disease.2016

    • Author(s)
      Miyoshi E, Shinzaki S, Fujii H, Iijima H, Kamada Y, Takehara T.
    • Journal Title

      Proteomics Clinical Applications

      Volume: 未定 Issue: 4 Pages: 384-390

    • DOI

      10.1002/prca.201500089

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Peyer's patches play a protective role in nonsteroidal anti-inflammatory drug-induced enteropathy in mice.2014

    • Author(s)
      Hiyama S, Iijima H, Shinzaki S, Inoue T, Shiraishi E, Kawai S, Araki M, Kato M, Hayashi Y, Nishida T, Fujii H, Mukai A, Shibata N, Sato S, Kiyono H, Gotoh K, Motooka D, Nakamura S, Iida T, Tsujii M, Takehara T.
    • Journal Title

      Inflamm Bowel Dis.

      Volume: 5 Issue: 5 Pages: 790-9

    • DOI

      10.1097/mib.0000000000000017

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Age of onset is associated with disease seasonality in inflammatory bowel disease: A multi-center observational study by the Osaka Gut Forum2016

    • Author(s)
      Araki M, Shinzaki S, Iijima H, et al.
    • Organizer
      10th Congress of ECCO
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2016-02-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Deficiency of CCR7 Exacerbates Non-Steroidal Anti-Inflammatory Drug-Induced Enteropathy in Mice.2016

    • Author(s)
      Yamaguchi T, Iijima H, Hiyama S, Araki M, Kawai S, Iwatani S, Hayashi Y, Shinzaki S, Takehara T.
    • Organizer
      Digestive Disease Week
    • Place of Presentation
      San Diego, USA
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Indigo Naturalis and Indigo Ameliorate Murine Dextran Sodium Sulfate-Induced Colitis Through the Activation of Aryl Hydrocarbon Receptor.2016

    • Author(s)
      Kawai S, Iijima H, Shinzaki S, Iwatani S, Yamaguchi T, Araki M, Hiyama S, Hayashi Y, Tsujii M, Takehara T.
    • Organizer
      Digestive Disease Week
    • Place of Presentation
      San Diego, USA
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 潰瘍性大腸炎患者におけるパイエル板拡大観察の臨床的有用性2016

    • Author(s)
      日山智史, 飯島英樹, 新崎信一郎, 竹原徹郎
    • Organizer
      日本消化器病学会近畿支部 第105回例会
    • Place of Presentation
      大阪国際交流センター
    • Related Report
      2016 Annual Research Report
  • [Presentation] 青黛(indigo naturalis)による腸炎改善効果およびその機序についての検討2016

    • Author(s)
      川井 翔一朗, 飯島英樹, 竹原 徹郎
    • Organizer
      第102回日本消化器病学会総会
    • Place of Presentation
      京王プラザ
    • Related Report
      2016 Annual Research Report
  • [Presentation] マウスの NSAID 起因性小腸粘膜傷害におけるケモカインレセプター CCR7 の役割2016

    • Author(s)
      山口利朗, 飯島英樹, 日山智史, 良原丈夫, 岩谷修子, 荒木学, 川井翔一朗, 林義人, 新崎信一郎, 竹原徹郎
    • Organizer
      日本消化器免疫学会
    • Place of Presentation
      京都
    • Related Report
      2016 Annual Research Report
  • [Presentation] Biologics for mild to moderate UC, necessary2015

    • Author(s)
      Iijima H
    • Organizer
      Annual Meeting of Asian Organization for Crohn's and Colitis,
    • Place of Presentation
      Beijin, China
    • Year and Date
      2015-06-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Fujii H, Shinzaki S, Iijima H, et al. Core fucosylation regulates T-Cell activation and ameliorates murine colitis2015

    • Author(s)
      Fujii H, Shinzaki S, Iijima H, et al.
    • Organizer
      Digestive Disease Week
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2015-05-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Age of onset is associated with seasonality of onset and exacerbation in inflammatory bowel disease: A multi-center observational study by the Osaka Gut Forum2015

    • Author(s)
      Araki M, Shinzaki S, Iijima H, et al.
    • Organizer
      Digestive Disease Week
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2015-05-16
    • Related Report
      2015 Research-status Report
  • [Presentation] パイエル板はNSAID起因性小腸粘膜傷害に保護的に働く2014

    • Author(s)
      日山智史 ;飯島英樹 ;辻井正彦 ;竹原徹郎
    • Organizer
      日本消化器病学会近畿支部 第101回例会
    • Place of Presentation
      大阪国際交流センター
    • Year and Date
      2014-10-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Observation of Peyer's Patches Using Narrow Band Imaging With Magnifying Endoscopy Is Useful in Predicting the Recurrence of Ulcerative Colitis2014

    • Author(s)
      Satoshi Hiyama, Hideki Iijima, Shinichiro Shinzaki, et al.
    • Organizer
      DDW
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-05-05 – 2014-05-06
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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