Elucidation and therapeutic application of bone marrow-intestine coupling
| Project/Area Number |
26460975
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
有村 佳昭 札幌医科大学, 医学部, 研究員 (80305218)
仲瀬 裕志 札幌医科大学, 医学部, 教授 (60362498)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 骨髄－腸管連関 / 間葉系幹細胞 / ニッチ / 腸炎 / 骨髄移植 / 幹細治療の最適化 / 骨髄間葉系幹細胞 |
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| Outline of Final Research Achievements |
The research purpose of ours is elucidation of the bone marrow-intestine coupling and an optimal therapeutic application of findings to intractable intestinal disorders. We confirmed that hematopoietic stem cells and supporting niche cells became dysregulated in colitic rats, leading to excessive inflammatory-cell infiltration to the colon. Administrated mesenchymal stem cells (MSCs) could normalize bone marrow niche resulting in suppression of inflammatory cell infiltration, or aggravation of colitis. Unfortunately, bone marrow transplantation-recipient rats which were induced colitis carried a significant morbidity. Furthermore, graft-derived MSCs in the recipient rats seldom repopulated in the colitic tissues. These obstacle made it impossible for meaningful scientific analysis in this model. The issue remains a future challenge to resolve the enigma of therapeutic efficacy of MSCs therapy.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Malignant potential of gastrointestinal cancers assessed by structural equation modeling2016
Author(s)
Shimizu H, Arimura Y, Onodera K, Takahashi H, Okahara S, Kodaira J, Oohashi H, Isshiki H, Kawakami K, Yamashita K, Shinomura Y, Hosokawa M
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Journal Title
PLoS ONE
Volume: 11
Issue: 2
Pages: e0149327-e0149327
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Low-frequency IL23R coding variant associated with Crohn's disease susceptibility in Japanese subjects identified by personal genomics analysis2015
Author(s)
Onodera K, Arimura Y, Isshiki H, Kawakami K, Nagaishi K, Yamashita K, Yamamoto E, Niinuma T, Naishiro Y, Suzuki H, Imai K, Shinomura Y
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Journal Title
PLoS ONE
Volume: 10
Issue: 9
Pages: e0137801-e0137801
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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