| Project/Area Number |
26461009
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
TAKAMI Taro 山口大学, 医学(系)研究科(研究院), 講師 (60511251)
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| Co-Investigator(Kenkyū-buntansha) |
藤澤 浩一 山口大学, 医学(系)研究科(研究院), 助教 (00448284)
山本 直樹 山口大学, 大学教育機構, 准教授 (90448283)
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| Research Collaborator |
AIBE Yuki
YONEDA Kenji
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 肝硬変 / 骨髄細胞 / 酸化ストレス / コラゲナーゼ活性 / 肝臓再生 / 骨髄間葉系幹細胞 / 肝線維化 / Matrix metalloproteinase / 肝硬変症 / 肝再生 |
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| Outline of Final Research Achievements |
For many liver cirrhosis (LC) patients, anti-viral therapy has enabled control and elimination of hepatitis virus, but substantial improvements in vital prognosis for decompensated LC have been prevented by liver fibrosis and hepatocellular carcinoma. To overcome these issues, we have been conducting clinical research to assess the safety of a less-invasive liver regeneration therapy that uses cultured autologous bone marrow mesenchymal stem cells (BMSCs) for decompensated LC. In this project, to develop a culture method for higher-functioning BMSCs that show both collagenase activity and the regulation of redox homeostasis, we finally identified specific factors to promote the proliferation of BMSCs through the analysis of cultured BMSCs that showed higher collagenase activity on a nanomaterial-coated dish that we developed.
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