The study for the protective response by innate immune system and functional specialization of Kupffer cells in the pathogenesis of NASH

• Project/Area Number: 26461010
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kochi University
• Principal Investigator: ONO Masafumi 高知大学, 教育研究部医療学系臨床医学部門, 准教授 (70304681)
• Co-Investigator(Kenkyū-buntansha): 中島 弘幸 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 免疫・微生物学, 助教 (10574064) ; 西原 利治 高知大学, 教育研究部医療学系臨床医学部門, 教授 (60145125)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: ＮＡＳＨ / Kupffer細胞 / CD68+Kupffer細胞 / CD11b+Kupffer細胞 / 腸内細菌 / NASH / 肝臓学 / CD１１b＋Kupffer細胞

Outline of Final Research Achievements

Although impairment of Kupffer cells are important for the pathogenesis of nonalcoholic steatohepatitis (NASH), the precise mechanisms of the impairment have not been well clarified yet. In this study, we have clarified that the CD11b+Kupffer cells increased and CD68+Kupffer cells decreased in the liver of NASH. In addition, inflammation and fibrosis were improved without attenuation of hepatic steatosis, when CD11b+Kupffer cells were decreased by exposing of 1Gy irradiation. In contrast, depletion of the resident subset, CD68+Kupffer cells, by clodronate liposome (c-lipo) treatment exacerbated disease progression. It was clarified that recruited CD11b+ CD68+ Kupffer cells may play an essential role in steatohepatitis and fibrosis in the pathogenesis of NASH. We concluded that recruitment and activation of bone marrow derived macrophages, CD11b+Kupffer cells, may have the important key factor to develop steatohepatitis from simple steatosis.

Research Products

• [Journal Article] 非アルコール性脂肪肝炎を来す薬剤 (2016)
  • Author(s): 宮村充彦，横田淳子，西原利治
  • Journal Title: 薬学雑誌 Volume: 136 Pages: 579-582
  • NAID: 130005140771
  • Open Access
• [Journal Article] FXR agonistとしての胆汁酸とその核内レセプターFXRの役割 (2016)
  • Author(s): 西原利治，廣瀬享，小野正文
  • Journal Title: 肝胆膵 Volume: 72 Pages: 853-858
  • Open Access
• [Journal Article] 診断の進め方：専門医への紹介のポイント (2016)
  • Author(s): 小野正文，西原利治
  • Journal Title: 日本内科学会雑誌 Volume: 105 Pages: 47-55
  • Peer Reviewed / Open Access
• [Journal Article] Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey. (2016)
  • Author(s): Tokushige K, Hyogo H, Nakajima T, Ono M, Kawaguchi T, Honda K, Eguchi Y, Nozaki Y, Kawanaka M, Tanaka S, Imajo K, Sumida Y, Kamada Y, Fujii H, Suzuki Y, Kogiso T, Karino Y, Munekage K, Kuromatsu R, Oeda S, Yanase M, Mori K, Ogawa Y, Seko Y, Takehara T, Itoh Y, Nakajima A, Kanemasa K, Saibara T
  • Journal Title: J Gastroenterol Volume: 印刷中 Issue: 6 Pages: 586-96
  • DOI: 10.1007/s00535-015-1129-1
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of ovarian responses to equine chorionic gonadotropin of aromatase-deficient mice with or without 17-estradiol supplementation. (2016)
  • Author(s): Katsumi Toda, Yoshihiro Hayashi, Masafumi Ono, Toshiji Saibara
  • Journal Title: Endocrinology Volume: 157 Issue: 5 Pages: 2093-2103
  • DOI: 10.1210/en.2015-1701
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Are genetic variations the most important risk factors for development of hepatocellular carcinoma? (2016)
  • Author(s): Ono M，Saibara T
  • Journal Title: J Gastroenterol. Volume: 51 Issue: 4 Pages: 404-5
  • DOI: 10.1007/s00535-015-1130-8
  • Peer Reviewed / Open Access
• [Journal Article] High fasting insulin concentrations may be a pivotal predictor for the severity of hepatic fibrosis beyond the glycemic status in non-alcoholic fatty liver disease patients before development of diabetes mellitus． (2016)
  • Author(s): Masuda K，Noguchi S，Ono M，Ochi T，Munekage K，Okamoto N，Suganuma N，Saibara T
  • Journal Title: Hepatol Res Volume: - Issue: 10 Pages: 983-990
  • DOI: 10.1111/hepr.12832
  • Peer Reviewed
• [Journal Article] Magnetic Resonance Imaging More Accurately Classifies Steatosis and Fibrosis in Nonalcoholic Fatty Liver Disease Than Transient Elastography. (2016)
  • Author(s): Imajo K, Kessoku T, Honda Y, Tomeno W, Ogawa Y, Mawatari H, Fujita K, Yoneda M, Taguri M, Hyogo H, Sumida Y, Ono M, Eguchi Y, Inoue T,Yamanaka T, Wada K, Saito S, Nakajima A
  • Journal Title: Gastroenterology Volume: 150 Issue: 3 Pages: 626-37
  • DOI: 10.1053/j.gastro.2015.11.048
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Suppression of miR-7 biogenesis by NF90-NF45 controls cell proliferation in hepatocellular carcinoma. (2016)
  • Author(s): Higuchi T, Todaka H, Sugiyama Y, Ono M, Tamaki N, Hatano E, Takezaki Y, Hanazaki K, Miwa T, Chin See LS, Morisawa K, Tsuda M, Taniguchi T, Sakamoto S
  • Journal Title: J Biol Chem Volume: 291 Pages: 21074-21084
  • Peer Reviewed
• [Journal Article] PNPLA3 is involved in hepatic fatty acid and triglyceride metabolism through XBP1 and modulation of endoplasmic reticulum stress in mice. (2016)
  • Author(s): Ochi T, Munekage K, Ono M, Higuchi T, Tsuda M, Hayashi Y, Okamoto N, Toda K, Sakamoto S, Oben JA, Saibara T
  • Journal Title: Hepatol Res Volume: 印刷中 Issue: 6 Pages: 584-592
  • DOI: 10.1111/hepr.12587
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 脂肪肝を防ぐ食生活と治療を考える (2016)
  • Author(s): 西原利治
  • Journal Title: 日本内科学会雑誌 Volume: 105 Pages: 406-10
• [Journal Article] A successful case of deceased donor liver transplantation for a patient with intrahepatic arterioportal fistula. (2015)
  • Author(s): Takagi K, Yagi T, Yoshida R, Shinoura S, Umeda Y, Nobuoka D, Watanabe N, Kuise T, Sui K, Hirose A, Tsuboi M, Ogasawara M, Iwasaki S, Saibara T, Fujiwara T.
  • Journal Title: Hepatol Res. Volume: - Issue: 13 Pages: 1409-1415
  • DOI: 10.1111/hepr.12701
  • Peer Reviewed / Open Access
• [Journal Article] A novel noninvasive diagnostic method for nonalcoholic steatohepatitis using two glycobiomarkers. (2015)
  • Author(s): Kamada Y, Ono M, Hyogo H, Fujii H, Sumida Y, Mori K, Tanaka S, Yamada M, Akita M, Mizutani K, Fujii H, Yamamoto A, Takamatsu S, Yoshida Y, Itoh Y, Kawada N, Chayama K, Saibara T, Takehara T, Miyoshi E
  • Journal Title: Hepatology. Volume: 62 Issue: 5 Pages: 1433-1443
  • DOI: 10.1002/hep.28002
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Biphasic effect of alcohol intake on the development of fatty liver disease. (2015)
  • Author(s): Takahashi H, Ono M, Ono N, Eguchi T, Fujimoto K, Chayama K, Saibara T, Anzai K, Eguchi Y
  • Journal Title: J Gastroenterol Volume: 50 Issue: 11 Pages: 1114-23
  • DOI: 10.1007/s00535-015-1058-z
  • Peer Reviewed / Open Access
• [Journal Article] Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. (2015)
  • Author(s): Watanabe S, Hashimoto E, Ikejima K, Uto H, Ono M, Sumida Y, Seike M,
  • Journal Title: J Gastroenterol Volume: 50(4) Issue: 4 Pages: 364-377
  • DOI: 10.1007/s00535-015-1050-7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. (2015)
  • Author(s): Watanabe S, Hashimoto E, Ikejima K, Uto H, Ono M, Sumida Y, Seike M, Takei Y, Takehara T, Tokushige K, Nakajima A, Yoneda M, Saibara T, Shiota G, Sakaida I, Nakamuta M, Mizuta T, Tsubouchi H, Sugano K, Shimosegawa T.
  • Journal Title: Hepatol Res. Volume: 45 Issue: 4 Pages: 363-377
  • DOI: 10.1111/hepr.12511
  • Peer Reviewed / Open Access
• [Journal Article] NASHはどれくらい存在するのか (2015)
  • Author(s): 越智経浩，小野正文，西原利治
  • Journal Title: Mebio Volume: 33 Pages: 4-9
• [Journal Article] NASH/NAFLDおよび肥満研究の最前線 (2015)
  • Author(s): 小野正文，西原利治
  • Journal Title: 分子消化器病 Volume: 12 Pages: 165-70
• [Journal Article] NAFLD、NASHの発症頻度はどれくらい？男女別および国内外の頻度について (2015)
  • Author(s): 小野正文，西原利治
  • Journal Title: Nutrition Care Volume: 8 Pages: 672-5
• [Journal Article] 肝臓における糖代謝の最新知見 (2015)
  • Author(s): 小野正文，越智経浩，西原利治
  • Journal Title: Diabetes Frontier Volume: 26 Pages: 287-96
• [Journal Article] 尿酸血症と非アルコール性脂肪性肝疾患（NAFLD・NASH） (2015)
  • Author(s): 西原利治
  • Journal Title: 尿酸と血糖 Volume: 1 Pages: 55-58
• [Journal Article] Prdx1 promotes pancreatic cancer cell invasion by modulating p38 MAPK activity. (2015)
  • Author(s): Taniuchi K, Furihata M, Hanazaki K, Iwasaki S, Tanaka K, Shimizu T, Saito M, Saibara T
  • Journal Title: Pancreas Volume: 44 Issue: 2 Pages: 331-340
  • DOI: 10.1097/mpa.0000000000000270
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Is nonalcoholic fatty liver disease a systemic disease that promotes extrahepatic cancer development？． (2014)
  • Author(s): Ono M
  • Journal Title: Hepatology Reseach Volume: 45 Issue: 7 Pages: 711-713
  • DOI: 10.1111/hepr.12435
  • Peer Reviewed / Open Access
• [Journal Article] Pilot study of liraglutide effects in nonalcoholic steatohepatitis and nonalcoholic fatty liver disease with glucose intolerance in Japanese patients (LEAN-J). (2014)
  • Author(s): Eguchi Y, Kitajima Y, Hyogo H, Takahashi H, Kojima M, Ono M, Araki N, Tanaka K, Yamaguchi M, Matsuda Y, Ide Y, Otsuka T, Ozaki I, Ono N,3 Eguchi T, Anzai K, and Japan Study Group for NAFLD (JSG-NAFLD)
  • Journal Title: Hepatol Res Volume: 45 Issue: 3 Pages: 269-78
  • DOI: 10.1111/hepr.12351
  • Peer Reviewed
• [Journal Article] Simple scoring system for predicting cirrhosis in nonalcoholic fatty liver disease. (2014)
  • Author(s): Kessoku T, Ogawa Y, Yoneda M, Imajo K, Sumida Y, Eguchi Y, Fujii H, Hyogo H, Ono M, Suzuki Y, Kawaguchi T, Chayama K, Tanaka S, Fujimoto K, Anzai K, Saibara T, Sata M, Itoh Y, Nakajima A, Okanoue T
  • Journal Title: World J Gastroenterol Volume: 20（29） Issue: 29 Pages: 10108-10114
  • DOI: 10.3748/wjg.v20.i29.10108
  • Peer Reviewed / Open Access
• [Journal Article] nsulin Resistance Correlated With the Severity of Liver Histology in Japanese NAFLD Patients: A Multicenter Retrospective Study. (2014)
  • Author(s): Kessoku T, Yoneda M, Sumida Y, Eguchi Y, Fujii H, Hyogo H, Ono M, Kawaguchi T, Nakajima A; Japan Study Group of NAFLD (JSG-NAFLD)
  • Journal Title: J Clin Gastroenterol Volume: 49 Issue: 2 Pages: 169-70
  • DOI: 10.1097/mcg.0000000000000186
  • Peer Reviewed
• [Journal Article] Clinical effects of fenofibrate on serum uric acids，triglyceride，and creatinine in patients with hypertriglyceridemia． (2014)
  • Author(s): Oe K，Ono M，Ochi T，Munekage K，Mizuta H，Masuda K，Okamoto N，Saibara T
  • Journal Title: Int Med J Volume: 21 Pages: 363-366
  • Peer Reviewed
• [Journal Article] Clinical Usage of Serum Ferritin to Assess Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease: Proceed with Caution. (2014)
  • Author(s): Yoneda M, Thomas E, Sumida Y, Imajo K, Eguchi Y, Hyogo H, Fujii H, Ono M, Kawaguchi T, Schiff ER
  • Journal Title: Hepatol Res Volume: 44 Issue: 14
  • DOI: 10.1111/hepr.12327
  • Peer Reviewed
• [Journal Article] Functional role of estrogen for regulation of serum uric acid levels in pre-monopause patients with breast cancer． (2014)
  • Author(s): Yoshioka R，Ono M，Oe K，Ochi T，Munekage K，Masuda K，Mizuta H，Okamoto N，Saibara T
  • Journal Title: Int Med J Volume: 21 Pages: 1-4
  • Peer Reviewed
• [Journal Article] Uric acid levels decrease with fibrosis progression in patients with nonalcoholic fatty liver disease. (2014)
  • Author(s): Yoneda M, Thomas E, Sumida Y, Imajo K, Hyogo H, Fujii H, Ono M, Kawaguchi T, Eguchi Y, Nakajima A
  • Journal Title: Clin Biochem Volume: 47 Issue: 12 Pages: 1138-9
  • DOI: 10.1016/j.clinbiochem.2014.04.026
  • Peer Reviewed
• [Journal Article] Type 2 diabetes mellitus is associated with the fibrosis severity in patients with nonalcoholic fatty liver disease in a large retrospective cohort of Japanese patients. (2014)
  • Author(s): Nakahara T, Hyogo H, Yoneda M, Sumida Y, Eguchi Y, Fujii H, Ono M, Kawaguchi T, Imajo K, Aikata H, Tanaka S, Kanemasa K, Fujimoto K, Anzai K, Saibara T, Sata M, Nakajima A, Itoh Y, Chayama K, Okanoue T
  • Journal Title: J Gastroenterol Volume: 49(11) Issue: 11 Pages: 1477-1484
  • DOI: 10.1007/s00535-013-0911-1
  • Peer Reviewed / Open Access
• [Journal Article] The association of insomnia with gastroesophageal reflux symptoms in biopsy-proven nonalcoholic fatty liver disease. (2014)
  • Author(s): Taketani H, Sumida Y, Tanaka S, Imajo K, Yoneda M, Hyogo H, Ono M, Fujii H, Eguchi Y, Kanemasa K, Chayama K, Itoh Y, Yoshikawa T, Saibara T, Fujimoto K, Nakajima A
  • Journal Title: J Gastroenterol Volume: 49(7) Issue: 7 Pages: 1163-1174
  • DOI: 10.1007/s00535-013-0871-5
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of Ki-67 index in EUS-FNA specimens for the assessment of malignancy risk in pancreatic neuroendocrine tumors. (2014)
  • Author(s): Hasegawa T, Yamao K, Hijioka S, Bhatia V, Mizuno N, Hara K, Imaoka H, Niwa Y, Tajika M, Kondo S, Tanaka T, Shimizu Y, Kinoshita T, Kohsaki T, Nishimori I, Iwasaki S, Saibara T, Hosoda W, Yatabe Y
  • Journal Title: Endoscopy Volume: 46(1) Issue: 01 Pages: 32-38
  • DOI: 10.1055/s-0033-1344958
  • Peer Reviewed / Open Access
• [Journal Article] Multicenter validation study of anti-programmed cell death-1 antibody as a serological marker for type 1 autoimmune hepatitis (2014)
  • Author(s): Miyake Y, Yamamoto K, Matsushita H, Abe M, Takahashi A, Umemura T, Tanaka A, Nakamuta M, Nakamoto Y, Ueno Y, Saibara T, Takikawa H, Yoshizawa K, Ohira H, Zeniya M, Onji M, Tsubouchi H; Intractable Liver and Biliary Diseases Study Group of Japan
  • Journal Title: Hepatol Res. Volume: 44 Issue: 13 Pages: 1299
  • DOI: 10.1111/hepr.12305
  • URL: https://pure.teikyo.jp/en/publications/6f889bac-b917-490d-b0ef-e4cf4c3bf010
  • Peer Reviewed / Open Access
• [Journal Article] Autoantibody status and histological variables influence biochemical response to treatment and long-term outcomes in Japanese patients with primary biliary cirrhosis (2014)
  • Author(s): Nakamura M, Kondo H, Tanaka A, Komori A, Ito M, Yamamoto K, Ohira H, Zeniya M, Hashimoto E, Honda M, Kaneko S, Ueno Y, Kikuchi K, Shimoda S, Harada K, Arai K, Miyake Y, Abe M, Taniai M, Saibara T, Sakisaka S, Takikawa H, Onji M, Tsubouchi H, Nakanuma Y, Ishibashi H.
  • Journal Title: Hepatol Res. Volume: 45 Issue: 8 Pages: 846
  • DOI: 10.1111/hepr.12423
  • URL: https://pure.teikyo.jp/en/publications/1683a604-b709-466e-aede-8daec31f4aa7
  • Peer Reviewed / Open Access
• [Journal Article] Simultaneous occurrence of gastric lipoma and early gastric cancer. (2014)
  • Author(s): Namikawa T, Munekage E, Mizuta H, Kobayashi M, Saibara T, Hanazaki K.
  • Journal Title: Endoscopy Volume: 46 Issue: S 01 Pages: E338-E339
  • DOI: 10.1055/s-0034-1377279
  • Peer Reviewed / Open Access
• [Journal Article] Safety and efficacy of image-guided enzyme-targeting radiosensitization and intraoperative radiotherapy for locally advanced unresectable pancreatic cancer. (2014)
  • Author(s): Nishioka A, Ogawa Y, Miyatake K, Tadokoro M, Nogami M, Hamada N, Kubota K, Kariya S, Kohsaki T, Saibara T, Okabayashi T, Hanazaki K
  • Journal Title: Oncol Lett Volume: 8 Pages: 404-408
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] KIF20A-mediated RNA granule transport system promotes the invasiveness of pancreatic cancer cells. (2014)
  • Author(s): Taniuchi K, Furihata M, Saibara T
  • Journal Title: Neoplasia Volume: 16 Issue: 12 Pages: 1082-1093
  • DOI: 10.1016/j.neo.2014.10.007
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] IGF2BP3-mediated translation in cell protrusions promotes cell invasiveness and metastasis of pancreatic cancer． (2014)
  • Author(s): Taniuchi K，Furihata M，Hanazaki K，Saito M，Saibara T
  • Journal Title: Oncotarget Volume: 30 Pages: 6832-6845
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] RUVBL1 directly binds actin filaments and induces formation of cell protrusions to promote pancreatic cancer cell invasion. (2014)
  • Author(s): Taniuchi K, Furihata M, Iwasaki S, Tanaka K, Shimizu T, Saito M, Saibara T
  • Journal Title: International Journal of Oncology Volume: 44 Issue: 6 Pages: 1945-1954
  • DOI: 10.3892/ijo.2014.2380
  • Peer Reviewed
• [Journal Article] NAFLDの診療・研究の進歩 (2014)
  • Author(s): 汐田剛史，宇都浩文，小野正文，徳重克年，角田圭雄，兵庫秀幸
  • Journal Title: 日本消化器病学会雑誌 Volume: 111 Pages: 42-60
  • NAID: 130003383343
• [Journal Article] 特集 肝臓に焦点を当てた糖尿病治療 肝臓の糖代謝 (2014)
  • Author(s): 小野正文，西原利治
  • Journal Title: 月刊 糖尿病DIABETES Volume: 6 Pages: 6-11
• [Journal Article] NASH肝癌の臨床的特徴 (2014)
  • Author(s): 羽柴基，小野正文，西原利治
  • Journal Title: 消化器の臨床 Volume: 17 Pages: 62-65
• [Journal Article] 診断の進歩（biomarker） (2014)
  • Author(s): 石川洋一，水田洋，西原利治
  • Journal Title: 肝胆膵 Volume: 69 Pages: 903-908
• [Journal Article] タモキシフェン (2014)
  • Author(s): 藤村靖子，西原桜子，西原利治
  • Journal Title: 肝胆膵 Volume: 68 Pages: 193-197
• [Journal Article] Bofutsushosan, a Japanese herbal (Kampo) medicine, attenuates progression of nonalcoholic steatohepatitis in mice (2013)
  • Author(s): Masafumi Ono, Mitsunari Ogasawara, Akira Hirose, Sachiko Mogami, Nobuhiro Ootake, Kosuke Aritake, Takuma Higuchi, Nobuto Okamoto, Shuji Sakamoto, Masahiro Yamamoto, Yoshihiro Urade, Toshiji Saibara, Jude A. Oben.
  • Journal Title: Journal of Gastroenterology Volume: 49(6) Issue: 6 Pages: 1065-1173
  • DOI: 10.1007/s00535-013-0852-8
  • Peer Reviewed / Open Access
• [Journal Article] The upper limit of normal serum alanine aminotransferase levels in Japanese subjects. (2013)
  • Author(s): Tanaka K,Ono M,Saibara T et.al
  • Journal Title: Hepatology Research Volume: 23 Issue: 12 Pages: 1196-1207
  • DOI: 10.1111/hepr.12293
  • Peer Reviewed / Open Access
• [Journal Article] A romatese-null mice expressing enhanc ed green fluorescent protein in germ cells provide a model system to ass ess estrogen-dependent ovulatory res ponses (2013)
  • Author(s): Toda K,Ono M,Saibara T(他3名)
  • Journal Title: Transgenic Res Volume: (E-pub) Issue: 2 Pages: 293-302
  • DOI: 10.1007/s11248-013-9771-y
  • Peer Reviewed / Open Access
• [Journal Article] Clinical efficacy of combination therapy with ME3738 and pegylated interferon-alpha-2a in patients with hepatitis C virus genotype 1. (2013)
  • Author(s): Saibara T, Enomoto N, Kaneko S, Chayama K, Sata M, Imawari M, Onishi S, Okita K.
  • Journal Title: Hepatol Res. Volume: Apr 19 Issue: 4 Pages: 410-419
  • DOI: 10.1111/hepr.12139
  • Peer Reviewed
• [Presentation] 非Ｂ非Ｃ肝がんの発症・予後とアルブミンの関連：Random Forest分析． (2016)
  • Author(s): 川口巧，小野正文，鳥村拓司
  • Organizer: 第20回日本肝臓学会大会(JDDW)
  • Place of Presentation: 神戸コンベンションセンター（兵庫県神戸市）
  • Year and Date: 2016-11-03
• [Presentation] INVOLVEMENT OF AGE-RAGE SYSTEM FOR THE DEVEL-OPMENT OF HEPATIC FIBROSIS IN NASH． (2016)
  • Author(s): Munegage K，Ono M，Ochi T，Ogasawara M，Hirose A，Fujimura Y ，Iwasaki S，Saibara T
  • Organizer: uegweek2016（24th United European Gastroenterology Week）
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2016-10-15
  • Int'l Joint Research
• [Presentation] NASHの肝線維化進展におけるAGE-RAGE系の関与について． (2016)
  • Author(s): 宗景玄祐，小野正文，西原利治
  • Organizer: 第52回日本肝臓学会総会
  • Place of Presentation: ホテルニューオータニ幕張・東京ベイ幕張ホール（千葉県千葉市）
  • Year and Date: 2016-05-19
• [Presentation] NAFLD患者の肝線維化進展抑制には早期からの高インスリン血症，血糖変動，DM発症抑制への対策が重要である (2016)
  • Author(s): 宗景玄祐，小野正文，西原利治
  • Organizer: 第102回日本消化器病学会総会．
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2016-04-21
• [Presentation] EFFICACY OF GLUTATHIONE FOR THE TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE:AN OPEN-LABEL,MULTICENTER,PROSPECTIVE STUDY． (2016)
  • Author(s): Kessoku T，Sumida Y，Imajo K，Honda Y，Ogawa Y，Yoneda M，Ono M，Egushi，Nakajima A
  • Organizer: EASL（51th Annual Meeting of The European Association For The Study of The Liver）
  • Place of Presentation: Spain, Barcelona
  • Year and Date: 2016-04-13
  • Int'l Joint Research
• [Presentation] PNPLA3 IS INVOLVED IN HEPATIC LIPIDS METABOLISM THROUGH XBP1 AND MODUALATION OF ENDOPLASMIC RETICULUM SYRESS IN MICE． (2016)
  • Author(s): Ono M，Ochi T，Munegage K，Ogasawara M，Hirose A，Nozaki-Fujimura Y，Okamoto N， Iwasaki S，Oben J，Saibara T
  • Organizer: EASL（51th Annual Meeting of The European Association For The Study of The Liver）
  • Place of Presentation: Spain, Barcelona
  • Year and Date: 2016-04-13
  • Int'l Joint Research
• [Presentation] 高インスリン血症は糖尿病未発症NAFLD患者の肝線維化進展に重要な因子である． (2015)
  • Author(s): 宗景玄祐，小野正文，西原利治
  • Organizer: 第41回日本肝臓学会西部
  • Place of Presentation: 名古屋国際会議場（愛知県・名古屋市）
  • Year and Date: 2015-12-03
• [Presentation] A novel noninvasive diagnostic method for nonalcoholic steatohepatitis（NASH） using two glycobiomarkers． (2015)
  • Author(s): Kamada Y，Ono M，Hyogo H，Fujii H，Sumida Y，Mori K，Tanaka S，Yamada M，Akita M，Mizutani K，Fujii H，Yamamoto A，Takamatsu S，Yoshida Y，Itoh Y，Kawada N，Chayama K，Saibara T，Takehara T，Miyoshi E
  • Organizer: AASLD The Liver Meeting
  • Place of Presentation: Sanfrancisco （USA）
  • Year and Date: 2015-11-13
  • Int'l Joint Research
• [Presentation] Risk factors for hepatocellular carcinoma recurrence in patients with nonalcoholic and alcoholic fatty liver disease： Japanese multicenter survey． (2015)
  • Author(s): Kogiso T，Hashimoto E，Hyogo H，Nakajima T，Ono M，Kawaguchi T，Honda K，Eguchi Y，Nozaki Y，Kawanaka M，Imajo K，Sumida Y，Kamada Y，Fujii H，Suzuki Y，Tokushige K
  • Organizer: A ASLD The Liver Meeting
  • Place of Presentation: Sanfrancisco （USA）
  • Year and Date: 2015-11-13
  • Int'l Joint Research
• [Presentation] 糖尿病発症前NAFLD患者の肝線維化進展に寄与する因子の解析-男女別の比較検討より- (2015)
  • Author(s): 久家直子，小野正文，増田弘誠，宗景玄祐，越智経浩，西原利治
  • Organizer: 第11回消化器病における性差医学・医療研究会
  • Place of Presentation: 旭川グランドホテル（北海道・旭川市）
  • Year and Date: 2015-07-25
• [Presentation] 脂肪肝発症に対する性差の影響について-多施設検診受診者の解析より- (2015)
  • Author(s): 黒川早紀，宗景玄祐，越智経浩，高橋宏和，兵庫秀幸，小野正文，江口有一郎，西原利治
  • Organizer: 第11回消化器病における性差医学・医療研究会
  • Place of Presentation: 旭川グランドホテル（北海道・旭川市）
  • Year and Date: 2015-07-25
• [Presentation] C型慢性肝炎患者とNAFLD患者の血糖日中変動に影響を及ぼす要因についての比較検討． (2015)
  • Author(s): 越智経浩，小野正文，西原利治
  • Organizer: 第101回日本消化器病学会総会
  • Place of Presentation: 仙台国際センター（宮城県・仙台市）
  • Year and Date: 2015-04-23
• [Presentation] PNPLA3遺伝子はER stressを介したapoptosisに関与する (2015)
  • Author(s): 越智経浩，宗景玄祐，小野正文
  • Organizer: 第101回日本消化器病学会総会
  • Place of Presentation: 仙台国際センター（宮城県・仙台市）
  • Year and Date: 2015-04-23
• [Presentation] 脂肪肝に対する肥満と飲酒の影響について (2015)
  • Author(s): 小野正文，江口有一郎，兵庫秀幸，西原利治
  • Organizer: 第34回アルコール医学生物研究会
  • Place of Presentation: ホテルグリーンパーク津（三重）
  • Year and Date: 2015-01-23 – 2015-01-24
• [Presentation] Ruvbl1 directly binds actin filaments and induces formation of cell protrusions to promote pancreatic cancer cell invasion． (2014)
  • Author(s): Taniuchi K，Furihata M，Iwasaki S，Shimizu S，Shimizu T，Saito M，Saibara T
  • Organizer: Asian Pacific Digestive week 2014
  • Place of Presentation: Bali Nusa Dua Convention Center（Indonesia）
  • Year and Date: 2014-11-22 – 2014-11-25
• [Presentation] IgG4関連疾病に合併した門脈血栓症の一例 (2014)
  • Author(s): 江渕みのり，羽柴基，小笠原光成，廣瀬享，藤村靖子，麻植啓輔，小野正文，耕﨑拓大，岩﨑信二，西原利治，伊達慶一，岡林雄大，尾崎和秀
  • Organizer: 第102回日本消化器病学会四国支部例会
  • Place of Presentation: かがわ国際会議場（高松）
  • Year and Date: 2014-11-02 – 2014-11-03
• [Presentation] ESWL併用EPLBDが有用であった巨大総胆管結石症の1例． (2014)
  • Author(s): 麻植啓輔，耕﨑拓大，木岐淳，石川洋一，高橋友香里，西原利治
  • Organizer: 第113回日本消化器内視鏡学会四国支部例会．
  • Place of Presentation: かがわ国際会議場他（香川）
  • Year and Date: 2014-11-02 – 2014-11-03
• [Presentation] Sister Mary Joseph’s noduleを認めた膵癌1例． (2014)
  • Author(s): 木岐淳，耕﨑拓大，麻植啓輔，石川洋一，西原利治，濱田典彦，西岡明人，宗景匡哉，北川博之，花崎和弘，戸井慎，弘井誠
  • Organizer: 第102回日本消化器病学会四国支部例会．
  • Place of Presentation: かがわ国際会議場他（香川）
  • Year and Date: 2014-11-02 – 2014-11-03
• [Presentation] 膵悪性腫瘍に対するFOLFIRINOX療法の経験． (2014)
  • Author(s): 木岐淳，耕﨑拓大，麻植啓輔，石川洋一，西原利治，濱田典彦，西岡明人，宗景匡哉，北川博之，花崎和弘，弘井誠
  • Organizer: 第102回日本消化器病学会四国支部例会、第113回日本消化器内視鏡学会四国支部例会．
  • Place of Presentation: かがわ国際会議場他（香川）
  • Year and Date: 2014-11-02 – 2014-11-03
• [Presentation] PNPLA3遺伝子は小胞体ストレスによる肝脂肪酸代謝による (2014)
  • Author(s): 越智経浩，小野正文，西原利治
  • Organizer: 第56回日本消化器病学会大会
  • Place of Presentation: 神戸国際展示場（神戸）
  • Year and Date: 2014-10-23 – 2014-10-26
• [Presentation] Prdx1 promotes pancreatic cancer cell motility and invasion by modu-lating p38 mapk activity． (2014)
  • Author(s): Taniuchi K，Furihata M，Iwasaki S，Shimizu S，Shimizu T，Saito M，Saibara T
  • Organizer: uegweek2014
  • Place of Presentation: Austria center vienna（Austria）
  • Year and Date: 2014-10-18 – 2014-10-22
• [Presentation] 膵Solid Pseudopapillary Tumorの2例． (2014)
  • Author(s): 耕﨑拓大，木岐淳，麻植啓輔，石川洋一，西原利治，宗景匡哉，花﨑和弘，濱田典彦，西岡明人，弘井誠，耕﨑志乃
  • Organizer: JSAWI2014．
  • Place of Presentation: 淡路夢舞台国際会場（淡路）
  • Year and Date: 2014-09-05 – 2014-09-06
• [Presentation] NAFLD患者における肝脂肪化に対する肝脂肪酸β酸化能の影響-男女の比較解析結果より- (2014)
  • Author(s): 小野正文，増田弘誠，宗景玄祐，越智経浩，廣瀬享，西原利治，福本光孝，西岡明人，小川恭弘
  • Organizer: 第10回消化器病における性差医学・医療研究会
  • Place of Presentation: TKPガーデンシティ品川（東京）
  • Year and Date: 2014-07-26
• [Presentation] 飲酒は脂肪肝の「リスク」か？肥満，性差からみた脂肪肝との関連性の検討 (2014)
  • Author(s): 辻千賀，高橋宏和，小野正文，兵庫秀幸，北島陽一郎，小野尚文，江口尚久，江口有一郎，藤本一眞，茶山一彰，西原利治，安西慶三，江口有一郎
  • Organizer: 第10回消化器病における性差医学・医療研究会
  • Place of Presentation: TKPガーデンシティ品川（東京）
  • Year and Date: 2014-07-26
• [Presentation] 24時間血糖測定から見たNAFLDとC型慢性肝炎患者の耐糖能異常の特徴 (2014)
  • Author(s): 越智経浩，小野正文，川口巧，羽柴基，宗景玄祐，岡本宣人，西原利治
  • Organizer: 第1回肝臓と糖尿病・代謝研究会
  • Place of Presentation: 伊藤国際学術研究センター 伊藤謝恩ホール（東京）
  • Year and Date: 2014-07-03 – 2014-07-05
• [Presentation] 糖原病Ⅰ型に合併した肝細胞癌の1例 (2014)
  • Author(s): 北川達也，石川洋一，宗景匡哉，小笠原光成，廣瀬享，小野正文，岩﨑信二，小林道也，花﨑和弘，西原利治
  • Organizer: 第101回日本消化器病学会四国支部例会
  • Place of Presentation: 松山市総合コミュニティセンター（愛媛）
  • Year and Date: 2014-06-14 – 2014-06-15
• [Presentation] 腎癌術後20年目に遅発性膵転移を来した1例． (2014)
  • Author(s): 麻植啓輔，耕﨑拓大，木岐淳，石川洋一，西原利治，宗景匡哉，北川博之，花崎和弘，井上啓史，執印太郎，弘井誠
  • Organizer: 第101回日本消化器病学会四国支部例会．
  • Place of Presentation: 松山市総合コミュニティセンター（愛媛）
  • Year and Date: 2014-06-14 – 2014-06-15
• [Presentation] 当院における超音波内視鏡ガイド下胆道ドレナージ術の検討． (2014)
  • Author(s): 麻植啓輔，耕﨑拓大，木岐淳，石川洋一，羽柴基，西原利治，宗景匡哉，北川博之，並川努，花崎和弘
  • Organizer: 第101回日本消化器病学会四国支部例会、第112回日本消化器内視鏡学会四国支部例会合同
  • Place of Presentation: 松山市総合コミュニティセンター（愛媛）
  • Year and Date: 2014-06-14 – 2014-06-15
• [Presentation] 十二指腸乳頭部腺腫に対して内視鏡的乳頭切除術を施行した1例． (2014)
  • Author(s): 木岐淳，耕﨑拓大，麻植啓輔，石川洋一，西原利治，弘井誠，坂本芳也
  • Organizer: 第112回日本消化器内視鏡学会四国支部例会．
  • Place of Presentation: 松山市総合コミュニティセンター（愛媛）
  • Year and Date: 2014-06-14 – 2014-06-15
• [Presentation] Correlation between glucose intolerance and histological severity in non-alcoholic fatty liver disease. (2014)
  • Author(s): Ohmi S, Ono M, Nishi Y, Hirano S, Tsugita S, Takata H, Yoshimura K, Mori S, Terada Y, Saibara T, Fujimoto S
  • Organizer: American Diabetes Association 74th Scientific Sessions 2014
  • Place of Presentation: San Francisco, US
  • Year and Date: 2014-06-13 – 2014-06-17
• [Presentation] 治療による合併症等に難渋した重症自己免疫性肝炎の1例 (2014)
  • Author(s): 石川洋一，羽柴基，坪井麻記子，藤村靖子，小笠原光成，廣瀬享，高橋昌也，小野正文，岩﨑信二，西原利治
  • Organizer: 第110回日本内科学会四国地方会
  • Place of Presentation: あわぎんホール（徳島）
  • Year and Date: 2014-06-08
• [Presentation] 退形成性膵管癌の1例． (2014)
  • Author(s): 坪井麻記子，耕﨑拓大，麻植啓輔，木岐淳，石川洋一，吉岡玲子，西原利治，岡林雄大，志摩泰生，岩田純
  • Organizer: 第110回日本内科学会四国地方会．
  • Place of Presentation: あわぎんホール（徳島）
  • Year and Date: 2014-06-05 – 2014-06-06
• [Presentation] 基調講演 (2014)
  • Author(s): 西原利治
  • Organizer: 第50回日本肝癌研究会
  • Place of Presentation: 国立京都国際会館（京都）
  • Year and Date: 2014-06-05 – 2014-06-06
• [Presentation] 75gOGTTおよびCGMSから見たNAFLDの耐糖能異常の特徴について (2014)
  • Author(s): 小野正文，越智経浩，西原利治
  • Organizer: 第50回日本肝臓学会総会
  • Place of Presentation: ホテルニューオータニ（東京）
  • Year and Date: 2014-05-29 – 2014-05-30
• [Presentation] 胆膵癌による悪性十二指腸狭窄に対するthrough the scopeタイプの十二指腸ステント治療の検討． (2014)
  • Author(s): 耕﨑拓大，石川洋一，木岐淳，麻植啓輔，西原利治
  • Organizer: 第87回日本消化器内視鏡学会．
  • Place of Presentation: 福岡国際会議場（福岡）
  • Year and Date: 2014-05-15 – 2014-05-17
• [Presentation] CGMSからみたNAFLDとC型慢性肝炎の耐糖能異常の特徴と比較検討 (2014)
  • Author(s): 小野正文，川口巧，西原利治
  • Organizer: 第100回日本消化器病学会総会
  • Place of Presentation: 東京国際フォーラム（東京）
  • Year and Date: 2014-04-23 – 2014-04-26
• [Presentation] KIF20AはRNA結合蛋白質とメッセンジャーRNAの複合体を郵送することにより膵癌浸潤・転移を亢進させる． (2014)
  • Author(s): 谷内恵介，岩﨑信二，西原利治
  • Organizer: 第100回日本消化器病学会総会
  • Place of Presentation: 東京国際フォーラム（東京）
  • Year and Date: 2014-04-23 – 2014-04-26
• [Presentation] Insulin secretory function and HbA1c are related to liver fibrosis in nonalcoholic fatty liver disease． (2014)
  • Author(s): Eguchi Y，Kitajima Y，Takahashi H，Ono M，Okada M，Hyogo H，Sumida Y，Araki N，Ono N，Eguchi T，Iwakiri R，Anzai K，JSG-NAFLD
  • Organizer: EASL（49th Annual Meeting of The European Association For The Study of The Liver）
  • Place of Presentation: London UK
  • Year and Date: 2014-04-09 – 2014-04-13
• [Book] かかりつけ医と内科医のために (2014)
  • Author(s): 小野正文
  • Total Pages: 184
  • Publisher: 診断と治療社
• [Book] 最新肥満症学-基礎・臨床研究の最前線- (2014)
  • Author(s): 長谷川俊之，小野正文，西原利治
  • Total Pages: 724
  • Publisher: 日本臨床社