Factors for favorable acquirement of anti-HBsAb by HBV vaccination in healthy adults

• Project/Area Number: 26461027
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: National Center for Global Health and Medicine
• Principal Investigator: Murata Kazumoto 国立研究開発法人国立国際医療研究センター, その他部局等, 肝炎・免疫研究センター室長 (40345971)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: HBVワクチン / 抗体獲得不良 / 細胞内シグナル / 不顕性感染

Outline of Final Research Achievements

We analyzed a frequency of anti-HBs positive healthy volunteers (HV) without anti-HBc (that means previous infection of HBV). The frequency of anti-HBs positive with or without anti-HBc was similar. We found some HV did not memorize their histories of HBV vaccination, suggesting that each hospital should precisely control it.
We analyzed miR-181a in the naive CD4-T cells to study the factors for poor responses against HBV vaccination. miR-181a expression in the naive CD4-T cells was gradually decreased by their ages as previously reported. However, we were not able to demonstrate the association between miR-181a expression and poor response against HBV vaccination.　We thought one of factors for it should be multiple backgrounds of HBV vaccinees.

Research Products

• [Journal Article] Hepatitis B vaccination-related seroprevalence amon health-care personnel in a Japanese tertiary medical center (2016)
  • Author(s): Yanase M, Murata K, Mikami S, Nozaki Y, Masaki N, Mizokami M
  • Journal Title: Hepatol Res Volume: 46 Issue: 13 Pages: 1330-1337
  • DOI: 10.1111/hepr.12691
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Geographic distribution and characteristics of genotype A hepatitis B virus infection in acute and chronic hepatitis B patients in Japan. (2016)
  • Author(s): Ito, K, Yotsuyanagi H, Sugiyama M, Yatsuhashi H, Karino Y, Takikawa Y, Saito T, Arase Y, Imazeki F, Kurosaki M, Umemura T, Ichida T, Toyoda H, Yoneda M, Tanaka Y, Mita E, Yamamoto K, Michitaka K, Maeshiro T, Tanuma J, Korenaga M, Murata K, Masaki N, Koike K, Mizokami M.
  • Journal Title: J Gastroenterology and Hepatology Volume: 31 Issue: 1 Pages: 180-189
  • DOI: 10.1111/jgh.13030
  • Peer Reviewed
• [Journal Article] Induction of IFN-lambda3 as an additional effect of nucleotide, not nucleoside, analogues: a new potential target for HBV infection (2016)
  • Author(s): Murata, K. Asano, M. Matsumoto, A. Sugiyama, M. Nishida, N. Tanaka, E. Inoue, T. Sakamoto, M. Enomoto, N. Shirasaki, T. Honda, M. Kaneko, S. Gatanaga, H. Oka, S. Kawamura, Y. I. Dohi, T. Shuno, Y. Yano, H. Mizokami, M.
  • Journal Title: Gut Volume: - Issue: 2 Pages: 362-371
  • DOI: 10.1136/gutjnl-2016-312653
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hepatitis B virus vaccination-related seroprevalence among health-care personnel in a Japanese teritiary medical center (2016)
  • Author(s): Yanase M, Murata K, Mikami S, Nozaki Y, Masaki N, Mizokami M
  • Journal Title: Hepatol Res Volume: in press
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia. (2014)
  • Author(s): Nishida N, Sawai H, Kashiwase K, Minami M, Sugiyama M, Seto WK, Yuen MF, Posuwan N, Poovorawan Y, Ahn SH, Han KH, Matsuura K, Tanaka Y, Kurosaki M, Asahina Y, Izumi N, Kang JK, （省略）, Tokunaga K, and Mizokami M
  • Journal Title: PLoS One Volume: 9 Issue: 2 Pages: e86449-e86449
  • DOI: 10.1371/journal.pone.0086449
  • Peer Reviewed / Open Access
• [Presentation] Induction of IFN-lambda3 as an additional pharmacological effect of nucleotide, not nucleoside, analogs: A new potential target for HBV infection (2017)
  • Author(s): Murata K, Mizokami M
  • Organizer: Asian Pasific Association for the Study of Liver diseses
  • Place of Presentation: Shanghai, China
  • Year and Date: 2017-02-15
  • Int'l Joint Research
• [Presentation] Induction of IFN-lambda3 as an additional pharmacological effect of ADV or TDF: A new potential target for HBV infection (2016)
  • Author(s): Murata K, Mizokami M
  • Organizer: Asian Pasific Association for the Study of Liver diseses
  • Place of Presentation: Beijing, China
  • Year and Date: 2016-12-16
  • Int'l Joint Research
• [Presentation] IFN-lambda3 induction by nucleotide, not nucleoside, analogs and its clinical significance in HBV patients (2016)
  • Author(s): Murata K, Matsumoto A, Inoue T, Sakamoto M, Sugiyama M, Enomoto N, Tanaka E, Mizokami M
  • Organizer: American Association for the Study of Liver Diseases
  • Place of Presentation: Boston, MA< USA
  • Year and Date: 2016-11-13
  • Int'l Joint Research
• [Presentation] IFN-lambda3 induction by nucleotide, not nucleoside, analogs and its clinical significance in HBV patients (2015)
  • Author(s): Murata K, Matsumoto A, Inoue T, Sakamoto M, Sugiyama M, Enomoto N, Tアナ化E, Mizokami M
  • Organizer: American Association for the Study of Liver Disease
  • Place of Presentation: San Francisco
  • Year and Date: 2015-11-13
  • Int'l Joint Research
• [Presentation] 核酸アナログ製剤投与による新規発見サイトカインFactor Xの誘導とそれに伴うHBs抗原低下作用 (2015)
  • Author(s): 村田一素、松本晶博、溝上雅史
  • Organizer: 日本肝臓学会
  • Place of Presentation: 東京
  • Year and Date: 2015-10-08