The establishment of novel endoscopic diagnostic method and biomarker for cholangiocarcinoma by fluorescence in situ hybridization
Project/Area Number |
26461046
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Nagoya City University |
Principal Investigator |
NAITOH Itaru 名古屋市立大学, 大学院医学研究科, 講師 (30527750)
|
Co-Investigator(Kenkyū-buntansha) |
中沢 貴宏 名古屋市立大学, 大学院医学研究科, 研究員 (70305522)
宮部 勝之 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (00543985)
|
Project Period (FY) |
2014-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | FISH法 / 胆管癌 / IgG4関連硬化性胆管炎 / 胆管生検 / 染色体異常 / 7番染色体 |
Outline of Final Research Achievements |
We evaluated the efficacy of fluorescence in situ hybridization (FISH) using transpapillary forceps biopsy specimens in the diagnosis of cholangiocarcinoma (CCA). We evaluated the copy number gains (> 2 copies) of CEP 3, 7, and 17 in patients with CCA and IgG4-related sclerosing cholangitis (IgG4-SC). The complementary use of FISH analysis using transpapillary forceps biopsy specimens improves the diagnostic yield for CCA in the differential diagnosis from IgG4-SC. Furthermore, a CEP 7 copy number gain may be a biomarker of poor prognosis in CCA patients.
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Report
(5 results)
Research Products
(13 results)
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[Journal Article] Autoimmune Hemolytic Anemia Obscured by the Obstructive Jaundice Associated with IgG4-related Sclerosing Cholangitis in a Patient with Type 1 Autoimmune Pancreatitis: A Case Report and Review of the Literature2018
Author(s)
Yoshida M, Marumo Y, Naitoh I, Hayashi K, Miyabe K, Nishi Y, Fujita Y, Jinno N, Hori Y, Natsume M, Kato A, Iida S, Joh T.
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Journal Title
Internal Medicine
Volume: 57
Issue: 12
Pages: 1725-1732
DOI
NAID
ISSN
0918-2918, 1349-7235
Year and Date
2018-06-15
Related Report
Peer Reviewed / Open Access
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[Journal Article] Case of pancreatic metastasis from colon cancer in which cell block using the Trefle® endoscopic scraper enables differential diagnosis from pancreatic cancer.2018
Author(s)
Kato A, Naitoh I, Kato H, Hayashi K, Miyabe K, Yoshida M, Hori Y, Natsume M, Jinno N, Yanagita T, Takiguchi S, Takahashi S, Joh T.
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Journal Title
World J Gastrointest Oncol.
Volume: 10
Issue: 3
Pages: 91-95
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] IgG4-related Sclerosing Cholangitis with No Biliary Stricture but Severe Thickening of the Bile Duct Wall2016
Author(s)
Shimizu S, Naitoh I, Nakazawa T, Hayashi K, Miyabe K, Kondo H, Nishi Y, Yoshida M, Umemura S, Hori Y, Kato A, Ohara H, Kuno T, Takahashi S, Joh T.
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Journal Title
Internal Medicine
Volume: 55
Issue: 12
Pages: 1575-1579
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed / Open Access
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[Journal Article] Predictive factors for positive diagnosis of malignant biliary strictures by transpapillary brush cytology and forceps biopsy2016
Author(s)
Naitoh I, Nakazawa T, Kato A, Hayashi K, Miyabe K, Shimizu S, Kondo H, Nishi Y, Yoshida M, Umemura S, Hori Y, Kuno T, Takahashi S, Ohara H, Joh T
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Journal Title
J Dig Dis
Volume: 17
Issue: 1
Pages: 44-51
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Locus/Chromosome aberrations in intraductal papillary mucinous neoplasms analyzed by fluorescence in situ hybridization.2015
Author(s)
Miyabe K, Hori Y, Nakazawa T, Hayashi K, Naitoh I, Shimizu S, Kondo H, Nishi Y, Yoshida M, Umemura S, Kato A, Ohara H, Joh T, Inagaki H.
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Journal Title
Am J Surg Pathol.
Volume: 39
Issue: 4
Pages: 512-20
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Predictive factors for positive diagnosis of malignant biliary strictures by transpapillary brush cytology and forceps biopsy2015
Author(s)
Kondo H, Naitoh I, Nakazawa T, Hayashi K, Miyabe K, Shimizu S,Nishi Y, Yoshida M, Umemura S, Hori Y, Kato A, Ohara H, Joh T
Organizer
UEGW 2015
Place of Presentation
Barcelona, Spain
Year and Date
2015-10-26
Related Report
Int'l Joint Research
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[Presentation] Evaluation of Chromosomal Abnormalities by Fluorescence in Situ Hybridization in intraductal papillary mucinous neoplasm2014
Author(s)
Miyabe K, Hori Y, Nakazawa T, Hayashi K, Naitoh I, Shimizu S, Kondo H, Nishi Y, Yoshida M, Umemura S, Kato A, Ohara H, Joh T, Inagaki H.
Organizer
DDW 2014
Place of Presentation
Chicago (United States)
Year and Date
2014-05-04 – 2015-05-04
Related Report
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