2017 Fiscal Year Final Research Report
The establishment of novel endoscopic diagnostic method and biomarker for cholangiocarcinoma by fluorescence in situ hybridization
Project/Area Number |
26461046
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Nagoya City University |
Principal Investigator |
NAITOH Itaru 名古屋市立大学, 大学院医学研究科, 講師 (30527750)
|
Co-Investigator(Kenkyū-buntansha) |
中沢 貴宏 名古屋市立大学, 大学院医学研究科, 研究員 (70305522)
宮部 勝之 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (00543985)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Keywords | FISH法 / 胆管癌 / IgG4関連硬化性胆管炎 / 胆管生検 / 染色体異常 |
Outline of Final Research Achievements |
We evaluated the efficacy of fluorescence in situ hybridization (FISH) using transpapillary forceps biopsy specimens in the diagnosis of cholangiocarcinoma (CCA). We evaluated the copy number gains (> 2 copies) of CEP 3, 7, and 17 in patients with CCA and IgG4-related sclerosing cholangitis (IgG4-SC). The complementary use of FISH analysis using transpapillary forceps biopsy specimens improves the diagnostic yield for CCA in the differential diagnosis from IgG4-SC. Furthermore, a CEP 7 copy number gain may be a biomarker of poor prognosis in CCA patients.
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Free Research Field |
消化器内科 胆膵領域
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