Basic researches of allogeneic cell sheets and novel devices for esophageal regeneration
Project/Area Number |
26461049
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Tokyo Women's Medical University |
Principal Investigator |
Kanai Nobuo 東京女子医科大学, 医学部, 特任講師 (90318056)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 細胞治療 / 細胞シート / アンメットメディカルニーズ / 3Dプリンター / 移植デバイス / 再生医療 / 同種細胞 / 細胞移植 / 上皮細胞 / 治験 / 臨床研究 / 再生医療安全確保法 / 医療機器 / デバイス / 他家細胞 |
Outline of Final Research Achievements |
In order to overcome the unmet medical needs in the field of the esophageal area, we are developing of esophageal regenerative treatment using epithelial cell sheet. In this project, we researched the feasibility of allogeneic cell sheet transplantation in a porcine model and developed the novel delivery devices for cell sheets transplantation using 3D printer. In this basic research, We succeeded in developing the animal esophageal stricture model and obtained results that allogeneic cell sheets transplantation avoiding severe esophageal stricture. In developing research, We successfully developed endoscopic delivery devices for sheet-like therapeutic substances using 3D printer.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Transplantation of tissue-engineered cell sheets for stricture prevention after endoscopic submucosal dissection of the oesophagus.2016
Author(s)
Eduard J, Sebastian S, Peter E, Nobuo K, Jennt E, Stephan L H, Ammar M, Teruo O, Ryo T, Takeshi O, Masakazu Y, Makoto K, Kartin M, Mei L, Masayuki Y, Magnus N, Jphan P, Pontus B, J-Matthias L
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Journal Title
United European Gastroenterology
Volume: 4(6)
Issue: 6
Pages: 741-753
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Report of the International Regulatory Forum on Human Cell Therapy and Gene Therapy Products2016
Author(s)
Hayakawa T, Harris I, Joung J, Kanai N, Kawamata S, Kellathur S, Koga J, Lin Yi-C, Maruyama Y, McBlane J, Nishimura T, Renner M, Ridgway A, Salmikangas P, Sakamoto N, Sato D, Sato Y, Toda Y, Umezawa A, Werner M, Wicks S
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Journal Title
Biologicals
Volume: 44
Issue: 5
Pages: 467-479
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Prevention of esophageal strictures after endoscopic submucosal dissection2014
Author(s)
Kobayashi S, Kanai N, Ohki T, Takagi R, Yamaguchi N, Isomoto H, Kasai Y, Hosoi T, Nakao K, Eguchi S, Yamamoto M, Yamato M, Okano T
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Journal Title
World Journal of Gastroenterology
Volume: 20(41)
Issue: 41
Pages: 15098-15109
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] Prevention of post-ESD esophageal stricture using endoscopic transplantation of tissue-engineered antologous oral mucosal epithelial cell sheets in the end of round trip transportation between Tokyo and Nagasaki2014
Author(s)
Kanai N, Isomoto H, Yamagushi N, Fukuda H, Nakao K, Kobayashi S, Kanetaka K, Sakai Y, Eguchi S, Ohki T, Yamato M, Okano T
Organizer
UEGW2014
Place of Presentation
Viennna, Republic of Austria
Year and Date
2014-10-20 – 2014-10-23
Related Report
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