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Basic researches of allogeneic cell sheets and novel devices for esophageal regeneration

Research Project

Project/Area Number 26461049
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionTokyo Women's Medical University

Principal Investigator

Kanai Nobuo  東京女子医科大学, 医学部, 特任講師 (90318056)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords細胞治療 / 細胞シート / アンメットメディカルニーズ / 3Dプリンター / 移植デバイス / 再生医療 / 同種細胞 / 細胞移植 / 上皮細胞 / 治験 / 臨床研究 / 再生医療安全確保法 / 医療機器 / デバイス / 他家細胞
Outline of Final Research Achievements

In order to overcome the unmet medical needs in the field of the esophageal area, we are developing of esophageal regenerative treatment using epithelial cell sheet. In this project, we researched the feasibility of allogeneic cell sheet transplantation in a porcine model and developed the novel delivery devices for cell sheets transplantation using 3D printer. In this basic research, We succeeded in developing the animal esophageal stricture model and obtained results that allogeneic cell sheets transplantation avoiding severe esophageal stricture. In developing research, We successfully developed endoscopic delivery devices for sheet-like therapeutic substances using 3D printer.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (35 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (11 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 8 results,  Open Access: 8 results,  Acknowledgement Compliant: 2 results) Presentation (12 results) (of which Int'l Joint Research: 4 results,  Invited: 6 results) Book (6 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] Karolinska Institute/Karolinska University Hospital(スウェーデン)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] Asan Medical Center(韓国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Transplantation of epidermal cell sheets by endoscopic balloon dilatation to avoid esophageal re-strictures: initial experience in a porcine model.2016

    • Author(s)
      Shinichiro Kobayashi, Nobuo Kanai, Nobuyuki Tanaka, Masanori Maeda, Takahiro Hosoi, Fumio Fukai, Susumu Eguchi, and Masayuki Yamato
    • Journal Title

      Endosc International Open

      Volume: 4 Issue: 11 Pages: 1116-1123

    • DOI

      10.1055/s-0042-116145

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Treatment of chemically-induced oral ulcer using adipose-derived mesenchymal stem cell sheet.2016

    • Author(s)
      Lee Doh Young, Kim Hee-Bok, Shim In Kyoung, Kanai N, Okano T, Kwon Seong Keun
    • Journal Title

      Journal of Oral Pathology and Medicine

      Volume: epub Issue: 7 Pages: 520-527

    • DOI

      10.1111/jop.12517

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transplantation of tissue-engineered cell sheets for stricture prevention after endoscopic submucosal dissection of the oesophagus.2016

    • Author(s)
      Eduard J, Sebastian S, Peter E, Nobuo K, Jennt E, Stephan L H, Ammar M, Teruo O, Ryo T, Takeshi O, Masakazu Y, Makoto K, Kartin M, Mei L, Masayuki Y, Magnus N, Jphan P, Pontus B, J-Matthias L
    • Journal Title

      United European Gastroenterology

      Volume: 4(6) Issue: 6 Pages: 741-753

    • DOI

      10.1177/2050640616631205

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Epithelial Cells Tissue Products for Prevention of Post-ESD Complications in the Area of Pharynx.2016

    • Author(s)
      Abe M, Kanai N, Hori K, Kawahara Y, Yamato M, Okada H
    • Journal Title

      Gastrointestinal Endoscopy

      Volume: 83(5) Issue: 5 Pages: 578-579

    • DOI

      10.1016/j.gie.2016.03.1193

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Report of the International Regulatory Forum on Human Cell Therapy and Gene Therapy Products2016

    • Author(s)
      Hayakawa T, Harris I, Joung J, Kanai N, Kawamata S, Kellathur S, Koga J, Lin Yi-C, Maruyama Y, McBlane J, Nishimura T, Renner M, Ridgway A, Salmikangas P, Sakamoto N, Sato D, Sato Y, Toda Y, Umezawa A, Werner M, Wicks S
    • Journal Title

      Biologicals

      Volume: 44 Issue: 5 Pages: 467-479

    • DOI

      10.1016/j.biologicals.2016.06.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Endoscopic cell sheet transplantation device developed by using a 3D printer and its feasibility evaluation in a porcine model2015

    • Author(s)
      Maeda M, Kanai N, Yamato M, Kobayashi S, Hosoi T, Takagi R, Ohki T, Muragaki Y, Yamato M, Okano T.
    • Journal Title

      Gastrointestinal Endoscopy

      Volume: accept Issue: 1 Pages: 147-152

    • DOI

      10.1016/j.gie.2015.01.062

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 細胞シート食道再生治療:日本・欧州で治験へ2015

    • Author(s)
      金井信雄, 大和雅之
    • Journal Title

      月刊細胞

      Volume: 47 Pages: 374-377

    • Related Report
      2015 Research-status Report
  • [Journal Article] 日本が発信する再生医療の実用化と展望2015

    • Author(s)
      金井信雄, 岡野光夫
    • Journal Title

      日本が発信する再生医療の実用化と展望

      Volume: 118 Pages: 171-175

    • NAID

      130005065311

    • Related Report
      2014 Research-status Report
  • [Journal Article] Cell sheets engineering for esophageal regenerative medicine2014

    • Author(s)
      Kanai N, Yamato M, Okano T
    • Journal Title

      Annals of Translational Medicine

      Volume: 2(3) Pages: 28-28

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevention of esophageal strictures after endoscopic submucosal dissection2014

    • Author(s)
      Kobayashi S, Kanai N, Ohki T, Takagi R, Yamaguchi N, Isomoto H, Kasai Y, Hosoi T, Nakao K, Eguchi S, Yamamoto M, Yamato M, Okano T
    • Journal Title

      World Journal of Gastroenterology

      Volume: 20(41) Issue: 41 Pages: 15098-15109

    • DOI

      10.3748/wjg.v20.i41.15098

    • NAID

      120006986311

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 普及を目指した他家細胞シート移植による食道再生医療の試み2014

    • Author(s)
      金井信雄, 大和雅之, 山本雅一, 岡野光夫
    • Journal Title

      最新医学

      Volume: 69 Pages: 178-185

    • Related Report
      2014 Research-status Report
  • [Presentation] 作用機序を考慮した上皮細胞シート製品の開発2017

    • Author(s)
      金井信雄, 大瀬賢介, 岩田隆紀, 大和雅之
    • Organizer
      第16回日本再生医療学会総会
    • Place of Presentation
      仙台国際センター(仙台市青葉区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Autologous epithelial cell sheet products for esophageal regeneration.2016

    • Author(s)
      Kanai N
    • Organizer
      TERMIS-AP
    • Place of Presentation
      台北(台湾)
    • Year and Date
      2016-09-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞シートを用いた再生医療の実用化を目指して「上皮細胞シートによる食道再生治療の開発」2016

    • Author(s)
      金井信雄
    • Organizer
      第22回日本遺伝子細胞治療学会
    • Place of Presentation
      虎ノ門ヒルズ(東京都港区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] シンポジウム1再生治療の最前線と今後:上皮細胞シート製品による食道再生治療、その目指すところ2016

    • Author(s)
      金井信雄, 腰野蔵人, 安部真, 大木岳志, 岡野光夫, 大和雅之
    • Organizer
      第37回日本炎症・再生医学会
    • Place of Presentation
      みやこめっせ(京都市左京区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] シンポジウム4(消化管領域における再生医療・幹細胞研究の現状)消化管領域における上皮細胞シート製品の有効性と新たな展開2016

    • Author(s)
      安部真, 金井信雄, 岡田裕之
    • Organizer
      第24回日本消化器関連学会週間
    • Place of Presentation
      神戸コンベンションセンター(神戸市中央区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Balloon dilatation with epidermal cell sheet transplantation to esophageal stricture for avoiding re-strictures- A new endoscopic procedure for regenerative medicine2015

    • Author(s)
      Kobayashi Shinichiro, Kanai Nobuo, Hosoi Takahiro, Maeda Masanori, Maruya Yasuhiro, Kanetaka Kengo, Eguchi Susumu, Yamato Masayuki
    • Organizer
      23rd United European Gastroenterology Week
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2015-10-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The development of a novel device for transplantation of cell sheets in the field of the pharynx2015

    • Author(s)
      Abe Makoto, Maeda Masanori, kanai Nobuo, Hori Keisuke, Kawahara Yoshiro, Okada Hiroyuki, Yamato Masayuki
    • Organizer
      23rd United European Gastroenterology
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2015-10-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] A novel endoscopic device for transplantation of tissue-engineered cell sheets2015

    • Author(s)
      Kanai Nobuo, Maeda Masanori, Kobayashi Shinichiro, Okano Teruo, Yamato Masayuki
    • Organizer
      4th TERMIS World congress
    • Place of Presentation
      Boston, USA
    • Year and Date
      2015-09-09
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 「気管食道科から発信する新規医療」細胞シートによる食道再生治療の普及を目指して2014

    • Author(s)
      金井信雄
    • Organizer
      第66回日本気管食道科学会
    • Place of Presentation
      高知市、高知県
    • Year and Date
      2014-11-13 – 2014-11-14
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Prevention of post-ESD esophageal stricture using endoscopic transplantation of tissue-engineered antologous oral mucosal epithelial cell sheets in the end of round trip transportation between Tokyo and Nagasaki2014

    • Author(s)
      Kanai N, Isomoto H, Yamagushi N, Fukuda H, Nakao K, Kobayashi S, Kanetaka K, Sakai Y, Eguchi S, Ohki T, Yamato M, Okano T
    • Organizer
      UEGW2014
    • Place of Presentation
      Viennna, Republic of Austria
    • Year and Date
      2014-10-20 – 2014-10-23
    • Related Report
      2014 Research-status Report
  • [Presentation] The analysis of esophageal mucosal healing and strictures after endoscopic submucosal dissection using allogeneic epidermal cell sheets in a porcine model2014

    • Author(s)
      Kobayashi S, Kanai N, Hosoi T, Yamato M, Okano T, Eguchi S
    • Organizer
      EMBO/EMBL Symposium Epithelia
    • Place of Presentation
      Heidelberg, Germany
    • Year and Date
      2014-08-28 – 2014-08-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 組織工学製品化を目指した再生医療研究 外科医と工学技術者が考案した細胞シート移植デバイス2014

    • Author(s)
      小林慎一朗, 金井信雄, 田中信行, 前田真法, 細井孝洋, 竹田一礼, 高木亮, 大和雅之, 岡野光夫, 江口晋
    • Organizer
      114回日本外科学会総会
    • Place of Presentation
      京都市、京都府
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Research-status Report
  • [Book] 先進医療NAVIGATOR今日の再生医療2016

    • Author(s)
      金井信雄
    • Total Pages
      5
    • Publisher
      日本医学出版
    • Related Report
      2016 Annual Research Report
  • [Book] 再生医療等製品の開発と実用化展望2016

    • Author(s)
      腰野蔵人, 金井信雄
    • Total Pages
      5
    • Publisher
      シーエムシー出版
    • Related Report
      2016 Annual Research Report
  • [Book] メディカルサイエンスダイジェスト2016

    • Author(s)
      腰野蔵人, 金井信雄, 大和雅之
    • Total Pages
      4
    • Publisher
      ニューサイエンス社
    • Related Report
      2016 Annual Research Report
  • [Book] 日本移植学会50周年記念誌2014

    • Author(s)
      金井信雄, 岡野光夫
    • Total Pages
      632
    • Publisher
      日本移植学会
    • Related Report
      2014 Research-status Report
  • [Book] Regenerative Medicine Application in Organ Transplantation2014

    • Author(s)
      Kanai N, Yamato M, Okano T
    • Total Pages
      1011
    • Publisher
      Elsevier
    • Related Report
      2014 Research-status Report
  • [Book] 先進医療NAVIGATORⅡ(再生医療・がん領域の実用化へのTOPICS)2014

    • Author(s)
      金井信雄
    • Total Pages
      188
    • Publisher
      日本医学出版
    • Related Report
      2014 Research-status Report
  • [Remarks] 東京女子医科大学 先端生命医科学研究所

    • URL

      http://gyoseki.twmu.ac.jp/twmhp/KgApp?kyoinId=ymdogbybggk

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京女子医科大学 研究業績ホームページ 金井信雄

    • URL

      http://gyoseki.twmu.ac.jp/twmhp/KgApp?kyoinId=ymdogbybggk

    • Related Report
      2015 Research-status Report
  • [Remarks] 東京女子医科大学 先端生命医科学研究所 研究業績

    • URL

      http://www.twmu.ac.jp/ABMES/ja/archives

    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] 治療物質運搬デバイス、及び治療物質運搬キット2015

    • Inventor(s)
      前田真法、金井信雄、安部真、藤井祐介、大和雅之
    • Industrial Property Rights Holder
      前田真法、金井信雄、安部真、藤井祐介、大和雅之
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-09-09
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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