| Project/Area Number |
26461064
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Gifu University |
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Principal Investigator |
AOYAMA Takuma 岐阜大学, 大学院医学系研究科, 非常勤講師 (60422713)
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| Co-Investigator(Renkei-kenkyūsha) |
MINATOGUCHI Shinya 岐阜大学, 大学院医学系研究科, 教授 (20190697)
SAWAMURA Tatsuya 信州大学, 学術研究院医学系, 教授 (30243033)
NISHIGAKI Kazuhiko 岐阜大学, 医学部附属病院, 准教授 (60198447)
TAKEMURA Genzou 朝日大学, 歯学部, 教授 (40283311)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 拡張型心筋症 / LOX-1 / 心不全 / sLOX-1 |
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| Outline of Final Research Achievements |
Severity assessment of dilated cardiomyopathy (DCM) was examined by measurement of sLOX-1. Concentration of soluble LOX-1 were not correlated with BNP and parameters of echocardiography. Next, we focused a question whether LOX-1 contributes to the pathogenesis of DOX-induced cardiomyopathy. Preserved left ventricular function of LOX-1 knockout (KO) mice compared with those of wild (WT) mice was found after DOX administration. Production of ROS, activation of NF-κB, production of TNF-α, expression of VCAM-1, and leukocyte infiltration were observed less in LOX-1 KO mice than WT mice. On the other hand, decreased expression of sarcometric proteins resulted in smaller diameters of CMs in WT mice than in LOX-1 KO mice. Interestingly, expression of LOX-1 in CMs was much more abundant than that in other cells.
LOX-1 in CMs plays the most important roles in the pathology of DOX-induced cardiomyopathy.
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