Study for cardioprotection of omega-3 polyunsaturated fatty acid
Project/Area Number |
26461065
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
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Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
Sato Hiroshi 浜松医科大学, 医学部附属病院, 講師 (30293632)
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Co-Investigator(Kenkyū-buntansha) |
漆田 毅 浜松医科大学, 医学部, 助教 (20334980)
林 秀晴 浜松医科大学, 医学部, 教授 (50135258)
早乙女 雅夫 浜松医科大学, 医学部附属病院, 助教 (70509512)
加藤 秀樹 浜松医科大学, 医学部, 助教 (80314029)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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Keywords | 不飽和脂肪酸 / 心筋細胞 / 冠動脈疾患 / ミトコンドリア / 培養心筋細胞 / 飽和脂肪酸 / ω-3不飽和脂肪酸 / 膜電位 / 細分化 |
Outline of Final Research Achievements |
(Basic study) When differentiated H9c2 myocytes were exposed to palmitate (PAL), the myocytes showed activation of caspases 3/7, depolarization of mitochondrial membrane potential, depletion of intracellular ATP, and enhancement of reactive oxygen species production. PAL enhanced mitochondrial fragmentation with increased dynamin-related protein-1 (Drp1) expression. Eicosapentaenoic acid (EPA) ameliorated the PAL-induced lipotoxicity via AMP-activated protein kinase activation, which suppressed mitochondrial fragmentation and Drp1 expression. (Clinical study) Patients with fish intake >=3 times/week showed higher EPA, DHA levels and EPA/AA ratio than those with <3 times/week. Both patients recommended fish intake and those treated with EPA showed decreases in serum MDA-LDLlevels after 2 years, but the extent did not differ. The increase in fish intake was as effective as the treatment with EPA for increases in serum omega-3 polyunsaturated fatty acids and a decrease in oxidative LDL.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Late gadolinium enhancement and therisk for ventricular arrhythmias or sudden death in dilated cardiomyopathy: Systematic review and meta-analysis.2016
Author(s)
Di Marco A, Anguera I, Schmitt M, Klem I, Neilan T, White JA, Sramko M, Masci PG, Barison A, Mckenna P, Mordi I, Haugaa KH, Leyva F, Rodriguez Capitán J, Satoh H, Nabeta T, Dallaglio PD, Campbell NG, Sabaté X, Cequier Á
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Journal Title
JACC Heart Fail
Volume: -
Issue: 1
Pages: 28-38
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Intra-left ventricular flow dynamics in patients with preserved and impaired left ventricular function: analysis with three-dimensional cine phase contrast magnetic resonance imaging (4D-Flow).2016
Author(s)
Suwa K, Saitoh T, Takehara Y, Sano M, Saotome M, Urushida T, Katoh H, Satoh H, Sugiyama M, Wakayama T, Alley M, Sakahara H, Hayashi H
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Journal Title
J Magn Reson Imaging
Volume: 44
Issue: 6
Pages: 1493-1503
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Aberrant serum polyunsaturated fatty acids profile is relevant with acute coronary syndrome.2016
Author(s)
Sakamoto A, Saotome M, Hosoya N, Kageyama S, Yoshizaki T, Takeuchi R, Murata K, Nawada R, Onodera T, Takizawa A, Satoh H, Hayashi H
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Journal Title
Heart and Vessels
Volume: -
Related Report
Peer Reviewed / Open Access
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[Journal Article] Characteristics of Intra-Left Atrial Flow Dynamics and Factors Affecting Formation of the Vortex Flow2014
Author(s)
Suwa K, Saitoh T, Takehara Y, Sano M, Nobuhara M, Saotome M, Urushida T, Katoh H, Satoh H, Sugiyama M, Wakayama T, Sakahara H, Hayashi H.
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Journal Title
Circulation Journal
Volume: 79
Issue: 1
Pages: 144-152
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Functional, morphological and electrocardiographical abnormalities in patients with apical hypertrophic cardiomyopathy and apical aneurysm: correlation with cardiac MR.2014
Author(s)
Suwa K, Satoh H, Sano M, Nobuhara M, Saitoh T, Saotome M, Urushida T, Katoh H, Tawarahara K, Ohtani H, Wakabayashi Y, Takase H, Terada H, Takehara Y, Sakahara H, Hayashi H
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Journal Title
Open Heart
Volume: 1
Issue: 1
Pages: e000124-e000124
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Distribution of late gadolinium enhancement in end-stage hypertrophic cardiomyopathy and dilated cardiomyopathy: differential diagnosis and prediction of cardiac outcome.2014
Author(s)
Machii M, Satoh H, Shiraki K, Saotome M, Urushida T, Katoh H, Takehara Y, Sakahara H, Ohtani H, Wakabayashi Y, Ukigai H, Tawarahara K, Hayashi H.
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Journal Title
Magn Reson Imaging.
Volume: 32
Issue: 2
Pages: 118-124
DOI
Related Report
Peer Reviewed
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[Presentation] Alterations in Left Ventricular (LV) Flow Dynamics in Patients with Intra-LV Thrombus: Analysis with 3D-Cine Phase Contrast MRI (4D-Flow)2017
Author(s)
Sakakibara T, Suwa K, Saitoh T, Takehara Y, Kaneko Y, Sakakibara T, Sano M, Saotome M, Urushida T, Katoh H, Satoh H, Sakahara H, Hayashi H.
Organizer
The 81th Annual Meeting of Japanese Circulation Society
Place of Presentation
金沢
Year and Date
2017-03-17
Related Report
Int'l Joint Research
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[Presentation] Measurements of tissue oxygen and hemoglobin on a near infra-red spectroscopy in emergency patients with poor general conditions.2015
Author(s)
Saitoh T, Kanayama N, Niwayama M, Satoh H, Takahashi Y, Hozumi H, Uchida T, Hayashi H, MD, Yoshino A:
Organizer
American Heart Association, Scientific Session 2015
Place of Presentation
オーランド、米国
Year and Date
2015-11-06
Related Report
Int'l Joint Research
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[Presentation] Alterations in Flow Patterns and Wall Shear Stress in Pulmonary Artery Visualized with Phase-resolved 3D Cine Phase Contrast MRI (4D-Flow) in Patients with Systemic Sclerosis.2015
Author(s)
Sakakibara T, Suwa K, Saitoh T, Takehara Y, Sano M, Saotome M, Urushida T, Katoh H, Satoh H, Alley M, Sakahara H, Hayashi H
Organizer
American Heart Association, Scientific Session 2015
Place of Presentation
オーランド、米国
Year and Date
2015-11-06
Related Report
Int'l Joint Research
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