Comprehensive genetic analysis in patients with idiopathic ventricular fibrillation
Project/Area Number |
26461087
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
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Research Institution | Keio University |
Principal Investigator |
Aizawa Yoshiyasu 慶應義塾大学, 医学部(信濃町), 特任講師 (20528145)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 不整脈 / 遺伝子解析 / 心室細動 / 右脚ブロック / 次世代シークエンサー / ブルガダ症候群 / 心臓突然死 / 特発性心室細動 / パッチクランプ法 / 疾患特異的iPS細胞 / 突然死 |
Outline of Final Research Achievements |
A total of 105 cases of idiopathic ventricular fibrillation were collected. There were 6 cases showing right bundle branch block. Rare variants were detected in ABCC8, CDH2, SCN3B, SCNN1B genes by the next generation sequencer. By investigating the novel genetic mutation and the mechanism of the development of ventricular fibrillation in this study, it is expected that elucidation of the pathology and tailor - made medicine for individual genotypes will be realized.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] A Novel Mechanism of Atrioventricular Block Following Transcatheter Closure of an Atrial Septal Defect.2016
Author(s)
Yamamoto T, Kanazawa H, Tanosaki S, Goto S, Kimura M, Tsuruta H, Itabashi Y, Murata M, Kunitomi A, Aizawa Y, Nishiyama T, Kohno T, Maekawa Y, Takatsuki S, Sano M, Igawa O, Fukuda K.
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Journal Title
JACC Cardiovasc Interv
Volume: 9(19)
Issue: 19
Pages: 2067-2069
DOI
Related Report
Peer Reviewed
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[Journal Article] Predictive factors of lead failure in patients implanted with cardiac devices2015
Author(s)
Aizawa Y, Negishi M, Kashimura S, Nakajima K, Kunitomi A, Katsumata Y, Nishiyama T, Kimura T, Nishiyama N, Fukumoto K, Tanimoto Y, Kohsaka S, Takatsuki S, Fukuda K
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Journal Title
Int J Cardiol
Volume: 199
Pages: 277-81
DOI
Related Report
Acknowledgement Compliant
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[Journal Article] Risk factors for early replacement of cardiovascular implantable electronic devices2015
Author(s)
Aizawa Y, Kunitomi A, Nakajima K, Kashimura S, Katsumata Y, Nishiyama T, Kimura T, Nishiyama N, Tanimoto Y, Kohsaka S, Takatsuki S, Fukuda K
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Journal Title
Int J Cardiol
Volume: 178
Pages: 99-101
DOI
Related Report
Peer Reviewed
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[Journal Article] Electrical storm in patients with brugada syndrome is associated with early repolarization.2014
Author(s)
Kaneko Y, Horie M, Niwano S, Kusano KF, Takatsuki S, Kurita T, Mitsuhashi T, Nakajima T, Irie T, Hasegawa K, Noda T, Kamakura S, Aizawa Y, Yasuoka R, Torigoe K Suzuki H, Ohe T, Shimizu A, Fukuda K, Kurabayashi M, Aizawa Y.
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Journal Title
Circ Arrhythm Electrophysiol.
Volume: 6
Issue: 6
Pages: 1122-8
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Circadian pattern of fibrillatory events in non-Brugada-type idiopathic ventricular fibrillation with a focus on J waves2014
Author(s)
Aizawa Y, Sato M, Ohno S, Horie M, Takatsuki S, Fukuda K, Chinushi M, Usui T, Aonuma K, Hosaka Y, Haissaguerre M, Aizawa Y
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Journal Title
Heart Rhythm
Volume: 11
Issue: 12
Pages: 2261-6
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Thoracic impedance as a therapeutic marker of acute decompensated heart failure2014
Author(s)
Aizawa Y, Takatsuki S, Kashimura S, Katsumata Y, Nishiyama T, Kimura T, Nishiyama N, Tanimoto Y, Tanimoto K, Fukuda Y, Sato T, Ogawa S, Fukuda K
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Journal Title
Int J Cardiol
Volume: 174
Issue: 2
Pages: 840-2
DOI
Related Report
Peer Reviewed
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[Presentation] Yoshiyasu Aizawa, Mitsushige, Murata, Kazuaki Nakajima, Akira Kunitomi, Shin Kashimura, Yoshinori Katsumata, Takahiko Nishiyama, Takehiro Kimura, Nobuhiro Nishiyama, Kotaro Fukumoto, Yoko Tanimoto, Seiji Takatsuki, Keiichi Fukuda.2016
Author(s)
Yoshiyasu Aizawa, Mitsushige, Murata, Kazuaki Nakajima, Akira Kunitomi, Shin Kashimura, Yoshinori Katsumata, Takahiko Nishiyama, Takehiro Kimura, Nobuhiro Nishiyama, Kotaro Fukumoto, Yoko Tanimoto, Seiji Takatsuki, Keiichi Fukuda.
Organizer
Heart Rhythm 2016
Place of Presentation
San Francisco, CA, USA
Year and Date
2016-05-05
Related Report
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[Presentation] Clinical Characteristics, and Long-term Outcome of the Dilated Phase of Hypertrophic Cardiomyopathy2016
Author(s)
Yoshiyasu Aizawa, Yoko Tanimoto , Mitsushige Murata , Mai Kimura , Yoshinori Katsumata , Takahiko Nishiyama , Takehiro Kimura , Nobuhiro Nishiyama , Kotaro Fukumoto , Shinsuke Yuasa , Takashi Kohno , Shun Kohsaka , Shinji Makino , Motoaki Sano , Seiji Takatsuki , Keiichi Fukuda
Organizer
第80回日本循環器学会学術集会
Place of Presentation
国際センター会議棟(宮城県仙台市)
Year and Date
2016-03-18
Related Report
Int'l Joint Research
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[Presentation] High Incidence of Lead Failure in Patients with Brugada Syndrome and Idiopathic Ventricular Fibrillation2016
Author(s)
Yoshiyasu Aizawa, Seiji Takatsuki , Kazuaki Nakajima , Shin Kashimura , Akira Kunitomi , Yoshinori Katsumata , Takahiko Nishiyama , Takehiro Kimura , Nobuhiro Nishiyama , Kotaro Fukumoto , Yoko Tanimoto , Shun Kohsaka , Keiichi Fukuda
Organizer
第80回日本循環器学会学術集会
Place of Presentation
国際センター展示棟(宮城県仙台市)
Year and Date
2016-03-18
Related Report
Int'l Joint Research
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[Presentation] Comparison of circadian, weekly and seasonal Comparison of circadian, weekly and seasonal variations between electrical storms versus single VF events in patients with Brugada syndrome2015
Author(s)
Yoshiyasu Aizawa, Seiji Takatsuki, Yoshinori Katsumata, Takahiko Nishiyama, Nobuhiro Nishiyama, Kotaro Fukumoto, Yoko Tanimoto, Yoshiaki Kaneko, Shinichi Niwano, Takashi Kurita, Takeshi Mitsuhashi, Takashi Noda, Shiro Kamakura, Akihiko Shimizu, Minoru Horie, Yoshifusa Aizawa, Keiichi Fukuda
Organizer
第30回日本不整脈学会学術大会・第32回日本心電学会学術集会
Place of Presentation
グランドプリンスホテル京都(京都府京都市)
Year and Date
2015-07-28
Related Report
Int'l Joint Research
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[Presentation] Sex-dependency of Sick Sinus Syndrome Phenotype in Female Members of Familial Brugada Syndrome2015
Author(s)
Yoshiyasu Aizawa, Seiji Takatsuki, Seiko Ohno, Satoshi Nagase, Shogo Ito, Kazuaki Nakajima, Shin Kashimura, Akira Kunitomi, Yoshinori Katsumata, Takahiko Nishiyama, Takehiro Kimura, Nobuhiro Nishiyama, Yoko Tanimoto, Satoshi Ogawa, Kenjiro Kosaki, Keiichi Fukuda
Organizer
Heart Rhythm Society
Place of Presentation
ボストン(米国)
Year and Date
2015-05-13
Related Report
Int'l Joint Research
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[Presentation] ラミンA/C変異を認めた家族性洞不全症候群の1例2015
Author(s)
中嶋一晶, 相澤義泰, 伊藤章吾, 樫村晋, 國富晃, 勝俣良紀, 西山崇比古, 木村雄弘, 西山信大, 谷本陽子, 湯浅槙介, 小崎健次郎, 福田恵一, 高月誠司
Organizer
第27回臨床不整脈研究会
Place of Presentation
東京都港区、東京コンファレンスセンター
Year and Date
2015-01-10
Related Report
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[Presentation] RyR2 Mutation may Underlie a Short-coupled Variant of Torsade de Pointes2014
Author(s)
Yoshiyasu Aizawa, Seiji Takatsuki, Shin Kashimura, Takahiko Nishiyama, Yoshinori Katsumata, Takehiro Kimura, Nobuhiro Nishiyama, Yoko Tanimoto, Kojiro Tanimoto, Hideo Mitamura, Kenjiro Kosaki, Keiichi Fukuda
Organizer
Heart Rhythm
Place of Presentation
米国サンフランシスコ、moscone convention center
Year and Date
2014-05-08
Related Report
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