Molecular imaging of disease activity in pulmonary arterial hypertension

• Project/Area Number: 26461097
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kurume University
• Principal Investigator: Tahara Nobuhiro 久留米大学, 医学部, 准教授 (10320186)
• Co-Investigator(Renkei-kenkyūsha): HONDA AKIHIRO 久留米大学, 医学部, 助教 (90624510) ; KAIDA HAYATO 近畿大学, 医学部, 講師 (40299425) ; UENO TAKAFUMI 久留米大学, 医学部, 助教 (60599819)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 肺高血圧症 / FDG-PET/CT / 肺血管障害 / 右心負荷 / 肺高血圧 / 分子イメージング

Outline of Final Research Achievements

We investigated lung parenchymal and myocardial glucose metabolism in patients with pulmonary arterial hypertension (PAH) by FDG-PET/CT. FDG activity in the lung parenchyma and right ventricle (R)/left ventricle (L) was measured by maximum standardized uptake values (SUV). The lung parenchymal SUV and SUVR/L values were significantly higher than non-PAH subjects, reflecting pulmonary vasculopathy and right ventricular workload, respectively. Pulmonary vasodilators significantly decreased SUVR/L values and NT-pro-BNP, but not lung parenchymal SUV values, concomitantly with improvement of pulmonary hemodynamics and RVEF. In multiple stepwise regression analysis, RVEF, mPAP and NT-proBNP were independently associated with SUVR/L. The change in RVEF was a sole and independent determinant with that in SUVR/L after treatment. The lung parenchymal SUV and SUVR/L values are associated with disease severity of PAH.

Research Products

• [Journal Article] Right ventricular workload assessed by FDG-PET in a patient with residual VSD and infundibular pulmonary stenosis after repair of tetralogy of Fallot (2018)
  • Author(s): Nakamura T, Tahara N, Tahara A, Honda A, Igata S, Bekki M, Sugiyama Y, Sun J, Kumagai E, Kurata S, Fujimoto K, Abe T, Kato S, Tanaka H, Fukumoto Y
  • Journal Title: J Nucl Cardiol Volume: 25 Issue: 3 Pages: 1053-1055
  • DOI: 10.1007/s12350-017-0906-z
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Myocardial metabolic improvement prior to electrocardiographic or volumetric changes of the right ventricle in pulmonary arterial hypertension (2018)
  • Author(s): Nakamura T, Tahara N,Tahara A, Yamagishi SI, Honda A, Igata S, Nitta Y, Bekki M, Nakamura T, Sugiyama Y, Sun J, Takeuchi M, Shimizu M, Yamazaki H, Fukami K, Fukumoto Y
  • Journal Title: J Nucl Cardiol Volume: 25 Issue: 1 Pages: 358-359
  • DOI: 10.1007/s12350-016-0769-8
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ratio of serum levels of AGEs to soluble RAGE is correlated with trimethylamine-N-oxide in non-diabetic subjects (2017)
  • Author(s): Tahara A, Tahara N, Yamagishi SI, Honda A, Igata S, Nitta Y, Bekki M, Nakamura T, Sugiyama Y, Sun J, Takeuchi M, Shimizu M, Yamazaki H, Fukami K, Fukumoto Y
  • Journal Title: Int J Food Sci Nutr Volume: 68 Issue: 8 Pages: 1013-1020
  • DOI: 10.1080/09637486.2017.1318117
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Efficacy and Safety of an Orally Administered Selective Prostacyclin Receptor Agonist, Selexipag, in Japanese Patients With Pulmonary Arterial Hypertension (2017)
  • Author(s): Tanabe N, Ikeda S, Tahara N, Fukuda K, Hatano M, Ito H, Nakayama T, Anzai T, Hashimoto A, Inoue T, Kajinami K, Kihara Y, Kinoshita H, Kuwahara K, Murohara T, Okazaki O, Sakai S, Satoh T, Takeda Y, Takeishi Y, Taniguchi M, Watanabe H, Yamamoto T, Yamauchi-Takihara K, Yoshioka K, Sasayama S.
  • Journal Title: Circulation Journal Volume: 81 Issue: 9 Pages: 1360-1367
  • DOI: 10.1253/circj.CJ-16-1348
  • NAID: 130006003900
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Acute heart failure caused by mechanical valve leaflet dislodgment at the mitral position. (2017)
  • Author(s): Nakamura T, Masumoto A, Tahara N, Kuroda Y, Fukumoto Y.
  • Journal Title: Eur Heart J. Volume: 38(10) Pages: 761-761
  • DOI: 10.1093/eurheartj/ehw521
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Differential Expression of Cardiac Troponin T and I in a Patient with Isolated Skeletal Muscular Sarcoidosis (2016)
  • Author(s): Mannoji H, Hayashi F, Kubota T, Ikeda Y, Ishibashi-Ueda H, Kato S, Tahara N, Fukutomi T, Yamada T, Okabe M, Yamamoto Y.
  • Journal Title: Internal Medicine Volume: 55 Issue: 21 Pages: 3215-3217
  • DOI: 10.2169/internalmedicine.55.6888
  • NAID: 130005276957
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Vascular Inflammation Evaluated by [18F]-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography Is Associated With Endothelial Dysfunction. (2016)
  • Author(s): Honda A, Tahara N, Nitta Y, Tahara A, Igata S, Bekki M, Nakamura T, Sugiyama Y, Kaida H, Kurata S, Fujimoto K, Abe T, Enomoto M, Adachi H, Narula J, Yamagishi S, Fukumoto Y.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 36(9) Issue: 9 Pages: 1980-1988
  • DOI: 10.1161/atvbaha.116.307293
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Anagliptin, A Dipeptidyl Peptidase-4 Inhibitor Ameliorates Arterial Stiffness in Association with Reduction of Remnant-Like Particle Cholesterol and Alanine Transaminase Levels in Type 2 Diabetic Patients. (2016)
  • Author(s): Tahara N, Yamagishi SI, Bekki M, Kodama N, Nakamura T, Sugiyama Y, Oshige T, Kumashiro Y, Honda A, Tahara A, Igata S, Fukumoto Y.
  • Journal Title: Curr Vasc Pharmacol. Volume: 14(6) Pages: 552-562
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] In Vivo Molecular Imaging of Ruptured Coronary Atherosclerotic Plaque Using IVUS, OCT, and FDG-PET/CT. (2016)
  • Author(s): Koiwaya H, Tahara N, Tahara A, Honda A, Igata S, Bekki M, Nakamura T, Sugiyama Y, Ohtsuka M, Kurata S, Fujimoto K, Abe T, Shibata Y, Ueno T, Fukumoto Y.
  • Journal Title: JACC Cardiovasc Interv. Volume: 9(12) Issue: 12 Pages: e113-e115
  • DOI: 10.1016/j.jcin.2016.03.013
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Efficacy and Safety of a Novel Endothelin Receptor Antagonist, Macitentan, in Japanese Patients With Pulmonary Arterial Hypertension (2016)
  • Author(s): Tahara N, Dobashi H, Fukuda K, Funauchi M, Hatano M, Ikeda S, Joho S, Kihara Y, Kimura T, Kondo T, Matsushita M, Minamino T, Nakanishi N, Ozaki Y, Saji T, Sakai S, Tanabe N, Watanabe H, Yamada H, Yoshioka K, Sasayama S
  • Journal Title: Circulation Journal Volume: 80 Issue: 6 Pages: 1478-1483
  • DOI: 10.1253/circj.CJ-15-1305
  • NAID: 130005153579
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Successful balloon pulmonary angioplasty with gadolinium contrast media for a patient with chronic thromboembolic pulmonary hypertension and iodine allergy (2016)
  • Author(s): Nakamura T, Ogo T, Tsuji A, Fukui S, Fukuda T, Tahara N, Fukumoto Y, Yasuda S, Ogawa H, Nakanishi N.
  • Journal Title: Respir Med Case Rep. Volume: 17 Pages: 75-82
  • DOI: 10.1016/j.rmcr.2016.02.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy and Safety of Inhaled Iloprost in Japanese Patients With Pulmonary Arterial Hypertension – Insights From the IBUKI and AIR Studies – (2016)
  • Author(s): Saji T, Myoishi M, Sugimura K, Tahara N, Takeda Y, Fukuda K, Olschewski H, Matsuda Y, Nikkho S, Satoh T.
  • Journal Title: Circulation Journal Volume: 80 Issue: 4 Pages: 835-842
  • DOI: 10.1253/circj.CJ-16-0097
  • NAID: 130005139552
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] FDG-PET reveals coronary artery inflammation proceeding to cardiac allograft vasculopathy progression. (2016)
  • Author(s): Sasaki M, Tahara N, Abe T, Ueno T, Fukumoto Y.
  • Journal Title: Eur Heart J. Volume: 37(30) Issue: 30 Pages: 2413-2413
  • DOI: 10.1093/eurheartj/ehw082
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] FDG-PET/CT images during 5 years before acute aortic dissection (2016)
  • Author(s): Nobuhiro Tahara, Saki Hirakata, Kota Okabe, Atsuko Tahara, Akihiro Honda, Sachiyo Igata, Hayato Kaida, Tohi Abe, Hidetoshi Akashi, Hiroyuki Tanaka, Yoshihiro Fukumoto
  • Journal Title: European Heart Journal Volume: 37巻10号 Issue: 24 Pages: 1933-1933
  • DOI: 10.1093/eurheartj/ehw075
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Optical frequency-domain imaging and pulmonary angioscopy in chronic thromboembolic pulmonary hypertension. (2016)
  • Author(s): Chibana H, Tahara N, Itaya N, Sasaki M, Sasaki M, Nakayoshi T, Ohtsuka M, Yokoyama S, Sasaki K, Ueno T, Fukumoto Y.
  • Journal Title: Eur Heart J. Volume: 37(16) Issue: 16 Pages: 1296-1304
  • DOI: 10.1093/eurheartj/ehv736
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Demonstration of the disease activity by serial carotid artery ultrasonography, magnetic resonance imaging and 18-fluoro-deoxyglucose positron emission tomography in a Behçet's disease patient with carotid artery stenosis. (2015)
  • Author(s): Igata S, Tahara N, Tahara A, Honda A, Nitta Y, Kusaba K, Niiyama H, Kaida H, Abe T, Yoshiyama H, Fukumoto Y.
  • Journal Title: Eur Heart J. Volume: 36(25) Issue: 25 Pages: 1629-1629
  • DOI: 10.1093/eurheartj/ehv031
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum levels of pigment epithelium-derived factor (PEDF) are inversely associated with circulating levels of dipeptidyl peptidase-4 (DPP-4) in humans. (2015)
  • Author(s): Tahara N, Yamagishi SI, Matsui T, Nishino Y, Honda A, Tahara A, Igata S, Fukumoto Y.
  • Journal Title: Int J Cardiol Volume: 184 Pages: 14-16
  • DOI: 10.1016/j.ijcard.2015.02.010
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Clinical and Biochemical Factors Associated With Area and Metabolic Activity in the Visceral and Subcutaneous Adipose Tissues by FDG-PET/CT. (2015)
  • Author(s): Tahara N, Yamagishi S, Kodama N, Tahara A, Honda A, Nitta Y, Igata S, Matsui T, Takeuchi M, Kaida H, Kurata S, Abe T, Fukumoto Y.
  • Journal Title: J Clin Endocrinol Metab. Volume: 100 Issue: 5 Pages: E739-E747
  • DOI: 10.1210/jc.2014-3896
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Persistent peripheral arteritis long after Kawasaki disease - another documentation of ongoing vascular inflammation. (2015)
  • Author(s): Suda K, Tahara N, Honda A, Iemura M, Yoshimoto H, Kudo Y, Kaida H, Abe T, Sawada K, Akashi H, Tanaka H, Fukumoto Y.
  • Journal Title: Int J Cardiol Volume: 180 Pages: 88-90
  • DOI: 10.1016/j.ijcard.2014.11.205
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Noninvasive evaluation of bone-forming activity within the calcified atherosclerotic lesions by Tc 99m HMDP scintigraphy. (2015)
  • Author(s): Tahara N, Tahara A, Honda A, Nitta Y, Igata S, Nakamura Y, Takeuchi Y, Akashi H, Tanaka H, Morioka M, Narula J, Yamagishi SI, Fukumoto Y.
  • Journal Title: JACC Cardiovasc Imaging Volume: 8 Issue: 1 Pages: 108-109
  • DOI: 10.1016/j.jcmg.2014.05.018
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Statin reduces persistent coronary arterial inflammation evaluated by serial 18fluorodeoxyglucose positron emission tomography imaging long after Kawasaki disease. (2015)
  • Author(s): Suda K, Tahara N, Honda A, Yoshimoto H, Kishimoto S, Kudo Y, Kaida H, Abe T, Ueno T, Fukumoto Y.
  • Journal Title: Int J Cardiol Volume: 179 Pages: 61-62
  • DOI: 10.1016/j.ijcard.2014.10.057
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Demonstration of the disease activity by serial carotid artery ultrasonography, magnetic resonance imaging and 18-fluoro-deoxyglucose positron emission tomography in a Behçet's disease patient with carotid artery stenosis. (2015)
  • Author(s): Igata S, Tahara N, Tahara A, Honda A, Nitta Y, Kusaba K, Niiyama H, Kaida H, Abe T, Yoshiyama H, Fukumoto Y.
  • Journal Title: Eur Heart J. Volume: in press
  • Peer Reviewed / Open Access
• [Journal Article] Noninvasive molecular imaging of cell death in myocardial infarction using 111In-GSAO. (2014)
  • Author(s): Tahara N, Zandbergen HR, de Haas HJ, Petrov A, Pandurangi R, Yamaki T, Zhou J, Imaizumi T, Slart RH, Dyszlewski M, Scarabelli T, Kini A, Reutelingsperger C, Narula N, Fuster V, Narula J.
  • Journal Title: Sci Rep. Volume: 4 Issue: 1 Pages: 6826-6826
  • DOI: 10.1038/srep06826
  • Peer Reviewed / Open Access
• [Journal Article] Positive correlation between malondialdehyde-modified low-density lipoprotein cholesterol and vascular inflammation evaluated by 18F-FDG PET/CT. (2014)
  • Author(s): Kaida H, Tahara N, Tahara A, Honda A, Nitta Y, Igata S, Ishibashi M, Yamagishi S, Fukumoto Y.
  • Journal Title: Atherosclerosis. Volume: 237 Issue: 2 Pages: 404-409
  • DOI: 10.1016/j.atherosclerosis.2014.10.001
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Vascular inflammation evaluated by FDG-PET/CT in adult patients with a history of Kawasaki disease (2017)
  • Author(s): 田原宣広
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 金沢市、石川県
  • Year and Date: 2017-03-17
• [Presentation] Clinical monitoring of inflammatory activity in atherosclerotic disease (2017)
  • Author(s): 田原宣広
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 金沢市、石川県
  • Year and Date: 2017-03-17
  • Invited
• [Presentation] Positron emission tomographyを用いた脳心血管病の評価 (2016)
  • Author(s): 田原宣広
  • Organizer: 脳心血管抗加齢研究会2016
  • Place of Presentation: 東京都
  • Year and Date: 2016-12-16
  • Invited
• [Presentation] Right ventricular mechanical dyssynchrony in pulmonary hypertension is associated with right ventricular performance and pulmonary hemodynamics (2016)
  • Author(s): Igata S, Tahara N, Tahara A, Honda A, Nitta Y, Sugiyama Y, Munehisa B, Nakamura T, Kumanomido J, Kumagai E, Fukumoto Y
  • Organizer: The American Heart Association, Scientific Sessions (AHA 2016)
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Myocardial Glucose Metabolism Evaluated by Fasting 18F-fluorodeoxyglucose (2016)
  • Author(s): Nakamura T, Tahara N, Sugiyama Y, Bekki M, Tahara A, Honda A, Kaida H, Kumagai E, Igata S, Fukumoto Y
  • Organizer: The American Heart Association, Scientific Sessions (AHA 2016)
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Clinical monitoring of inflammatory activity in atherosclerotic disease (2016)
  • Author(s): 田原宣広
  • Organizer: 第56回日本核医学会学術総会
  • Place of Presentation: 名古屋市、愛知県
  • Year and Date: 2016-11-03
  • Invited
• [Presentation] 肺血管拡張薬が右室におよぼす影響 (2016)
  • Author(s): 田原宣広
  • Organizer: 第1回肺高血圧学会
  • Place of Presentation: 東京都
  • Year and Date: 2016-10-01
  • Invited
• [Presentation] Vascular inflammation is associated with periodontal inflammation evaluated by FDG-PET/CT (2016)
  • Author(s): Nakamura T, Tahara N, Kaida H, Bekki M, Sugiyama Y, Tahara A, Honda A, Igata S, Fukumoto Y
  • Organizer: The 5th International Congress on Lipid Metabolism & Atherosclerosis 2016
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-09-09
  • Int'l Joint Research / Invited
• [Presentation] Diagnosis and Treatment of Cardiac Sarcoidosis guided by FDG-PET (2016)
  • Author(s): 田原宣広
  • Organizer: 第63 回日本不整脈心電学会学術大会
  • Place of Presentation: 札幌市、北海道
  • Year and Date: 2016-07-14
  • Invited
• [Presentation] Pioglitazone Decreases Carotid and Coronary Arterial Inflammation Evaluated by FDG-PET and CT Angiography in Patients with Impaired Glucose Tolerance or Type 2 Diabetes Mellitus (2016)
  • Author(s): Tahara N, Tahara A, Honda A, Nitta Y, Mizoguchi M, Nakamura T, Bekki M, Sugiyama Y, Igata S, Yamagishi SI, Fulumoto Y
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18
• [Presentation] Molecular Imaging of Atherosclerosis (2016)
  • Author(s): Tahara N, Tahara A, Honda A, Nitta Y, Mizoguchi M, Nakamura T, Bekki M, Sugiyama Y, Igata S, Fulumoto Y
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18
  • Invited
• [Presentation] 心アミロイドーシスの診断と生命予後 (2016)
  • Author(s): 田原宣広
  • Organizer: 第2回心筋症研究会
  • Place of Presentation: 松本市、長野県
  • Invited
• [Presentation] Aortic Inflammation Continues in Patients with A History of Kawasaki Disease and Persistent Arterial Aneurysms (2015)
  • Author(s): Suda K, Tahara N, Honda A, Nakamura T, Yoshimoto H, Kishimoto S, Kudo Y, Iemura M, Fukumoto Y.
  • Organizer: American Heart Association -87th Scientific Sessions
  • Place of Presentation: Orland, USA
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] 炎症と心血管病 (2015)
  • Author(s): 田原宣広、戸次宗久、中村知久、杦山陽一、田原敦子、本多亮博、新田良和、井形幸代、福本義弘
  • Organizer: 第55回日本核医学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2015-11-05
  • Invited
• [Presentation] 分子イメージングを用いた肺高血圧症の病態評価 (2015)
  • Author(s): 田原 宣広、中村知久、杦山陽一、戸次宗久、本多亮博、田原敦子、井形幸代、熊谷英太、大場豊治、福本 義弘
  • Organizer: 第4回肺循環学会・第3回肺高血圧学会
  • Place of Presentation: 東京
  • Year and Date: 2015-10-03
  • Invited
• [Presentation] 心サルコイドーシスの活動性に対する定量評価方法の開発 ― FDG-PETを用いた特発性拡張型心筋症との比較 ― (2015)
  • Author(s): 田原宣広、戸次宗久、中村知久、杦山陽一、田原敦子、本多亮博、新田良和、井形幸代、福本義弘
  • Organizer: 第63回日本心臓病学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2015-09-18
  • Invited
• [Presentation] 心アミロイドーシスの診断と生命予後 (2015)
  • Author(s): 田原宣広、大場豊治、本多亮博、田原敦子、新田良和、井形幸代、福本義弘
  • Organizer: 第3回日本アミロイドーシス研究会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-08-21
  • Invited
• [Presentation] 川崎病既往者の成人期における血管炎症活動性の評価 (2015)
  • Author(s): 田原宣広、中村知久、本多亮博、戸次宗久、杦山陽一、田原敦子、井形幸代、須田憲治、家村素史、工藤嘉公、岸本慎太郎、吉本 裕良、上野 高史、福本義弘
  • Organizer: 第24回日本心血管インターベンション治療学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-07-30
  • Invited
• [Presentation] 肺動脈性肺高血圧症における運動耐容能に関連する因子の検討 (2015)
  • Author(s): 田原宣広、高瀬文敬、井形幸代、本多亮博、田原敦子、新田良和、熊谷英太、大場豊治、福本義弘
  • Organizer: 第21回日本心臓リハビリテーション学会
  • Place of Presentation: 福岡
  • Year and Date: 2015-07-18
  • Invited
• [Presentation] A case of portopulmonary hypertension with Child-Pugh type B (2015)
  • Author(s): Tahara N
  • Organizer: 2nd Actelion Academic Forum in Pulmonary Hypertension
  • Place of Presentation: 東京
  • Year and Date: 2015-07-04
  • Int'l Joint Research / Invited
• [Presentation] 心筋の炎症をイメージングで評価できるか ～FDG-PETによる評価～ (2015)
  • Author(s): 田原宣広、戸次宗久、中村知久、杦山陽一、田原敦子、本多亮博、新田良和、井形幸代、福本義弘
  • Organizer: 第1回日本心筋症研究会
  • Place of Presentation: 東京
  • Year and Date: 2015-07-04
  • Invited
• [Presentation] Molecular Imaging of Inflammatory Activity in Atherosclerotic Lesions by FDG-PET (2015)
  • Author(s): Tahara N
  • Organizer: 2015 Seoul International Congress of Endocrinology and Metabolism (SICEM)
  • Place of Presentation: Korea
  • Year and Date: 2015-04-30
  • Int'l Joint Research / Invited
• [Presentation] Molecular Imaging of Inflammatory Activity in Atherosclerotic Lesions by FDG-PET (2015)
  • Author(s): 田原宣広、田原敦子、本多亮博、井形幸代、板家直樹、知花英俊、仲吉孝晴、大塚昌紀、小岩屋 宏、上野 高史、福本義弘
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24
  • Invited
• [Presentation] 循環器医から診る糖尿病治療への介入 ～マルチプルリスクを考える～ (2015)
  • Author(s): 田原宣広、本多亮博、田原敦子、新田良和、井形幸代、福本義弘
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24
  • Invited
• [Presentation] 薬物治療が可能なトランスサイレチン型アミロイドーシス ～早期診断のためのアプローチ～ (2015)
  • Author(s): 田原宣広、大場豊治、本多亮博、田原敦子、新田良和、井形幸代、福本義弘
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24
  • Invited
• [Presentation] インスリン抵抗性改善薬が動脈炎症に及ぼす影響 (2014)
  • Author(s): 田原宣広
  • Organizer: Alliance for Revolution and Interventional Cardiology Advancement : ARIA 2014
  • Place of Presentation: 福岡
  • Year and Date: 2014-11-21 – 2014-11-23
  • Invited
• [Presentation] Vascular Inflammation Evaluated by 18F-Fluorodeoxyglucose-Positron Emission Tomography/computed tomography is Associated with Endothelial Dysfunction. (2014)
  • Author(s): Honda A, Tahara N, Tahara A, Igata S, Nitta Y, Kodama N, Mizoguchi M, Yamagishi S, Imaizumi T.
  • Organizer: American Heart Association -87th Scientific Sessions
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Visceral fat metabolic activity is independently associated with coronary artery inflammation in patients with impaired glucose intolerance or type 2 diabetes. (2014)
  • Author(s): Igata S, Tahara N, Tahara A, Nitta Y, Honda A, Kodama N, Mizoguchi M, Yamagishi S, Imaizumi T
  • Organizer: American Heart Association -87th Scientific Sessions
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] FDG-PETで冠動脈に集積を認め、同部位を内視鏡で観察することができた2症例 (2014)
  • Author(s): 知花英俊, 田原宣広, 上野高史, 横山晋二, 佐々木健一郎, 大塚昌紀, 小岩屋宏, 仲吉孝晴, 光武良亮, 板家直樹, 佐々木雅浩, 佐々木基起, 福本義弘
  • Organizer: 第28回日本心臓血管内視鏡学会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-10-04
• [Presentation] 川崎病既往者の成人期動脈瘤における炎症活動性の評価 −FDG-PET/CT を用いた検討− (2014)
  • Author(s): 田原宣広
  • Organizer: 第34回日本川崎病学会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-01
  • Invited
• [Presentation] 耐糖能障害または2型糖尿病例における内臓脂肪のブドウ糖代謝は冠動脈炎症の独立した関連因子である (2014)
  • Author(s): 新田良和、田原宣広、田原敦子、本多亮博、児玉紀洋、溝口ミノリ、山岸昌一、福本義弘
  • Organizer: 第62回日本心臓病学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2014-09-25 – 2014-09-26
• [Presentation] FDG-PET/CTを用いた肺動脈性肺高血圧症の病態活動性の評価 (2014)
  • Author(s): 本多亮博、田原宣広、田原敦子、新田良和、児玉紀洋、福本義弘
  • Organizer: 第62回日本心臓病学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2014-09-25 – 2014-09-26
• [Presentation] 川崎病既往者の成人期動脈瘤における炎症活動性の評価 −FDG-PET/CT を用いた検討− (2014)
  • Author(s): 田原宣広
  • Organizer: 第23回日本心血管インターベンション治療学会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-07-24 – 2014-07-26
  • Invited
• [Presentation] 冠動脈硬化病変における炎症活動性の可視化 −FDG-PET/ 多列化CT を用いた検討− (2014)
  • Author(s): 田原宣広
  • Organizer: 第46回日本動脈硬化学会
  • Place of Presentation: 東京
  • Year and Date: 2014-07-10 – 2014-07-11
  • Invited
• [Presentation] 人は血管とともに老いる (2014)
  • Author(s): 田原宣広
  • Organizer: 第14回抗加齢医学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2014-06-06 – 2014-06-08
  • Invited
• [Book] Diagnosis Treatment of Pulmonary Hypertension: From Bench to Bedside Treatment of Chronic Thromboembolic Pulmonary Hypertension (CTEPH) (2016)
  • Author(s): Tahara N, Nakamura T, Chibana H , Kumagai E, Sugiyama Y, Bekki M, Honda A, Tahara A, Igata S, Fukumoto Y
  • Total Pages: 280
  • Publisher: Springer
• [Book] Annual Review 循環器 (2016)
  • Author(s): 元山貞子、皿井正義、松本有司、田原宣広
  • Total Pages: 280
  • Publisher: 中外医学社
• [Book] 右心不全を識り 評価して治療に活かす (2016)
  • Author(s): 中村知久、田原宣広、福本義弘
  • Total Pages: 169
  • Publisher: 文光堂
• [Book] Annual Review 循環器 (2016)
  • Author(s): 田原宣広、田原敦子、本多亮博、新田良和、井形幸代、福本義弘
  • Total Pages: 280
  • Publisher: 中外医学社
• [Book] 『心不全マネジメント2』右心不全を識り、評価して治療に活かす (2016)
  • Author(s): 中村知久、田原宣広
  • Total Pages: 169
  • Publisher: 文光堂
• [Book] ～早期診断・治療のための～肺高血圧症Q&A (2015)
  • Author(s): 大場豊治、田原宣広、福本義弘
  • Total Pages: 261
  • Publisher: 先端医学社
• [Book] ～早期診断・治療のための～肺高血圧症Q&A (2015)
  • Author(s): 田原宣広、杦山陽一、戸次宗久、中村知久、田原敦子、本多亮博、井形幸代、福本義弘
  • Total Pages: 261
  • Publisher: 先端医学社
• [Book] Cardiovascular Imaging. Arterial and Aortic Valve Inflammation and Calcification (2014)
  • Author(s): Tahara N, Tahara A, and Yamagishi S.
  • Total Pages: 389
  • Publisher: Springer International Publishing AG